Institut de Neurosciences Cognitives et Intégratives d'Aquitaine (UMR5287)

Aquitaine Institute for Cognitive and Integrative Neuroscience

Université de Bordeaux

Zone nord Bat 2 2ème étage
146, rue Léo Saignat
33076 Bordeaux cedex


Supervisory authorities

CNRS Ecole Pratique des Hautes Etudes Université de Bordeaux

Our partners

Neurocampus Unitéde Formation de Biologie


GDR Robotique GDR Mémoire GDR Multi-électrodes


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Thoby-Brisson Muriel

by Le Ray Didier - published on , updated on

Chargé de Recherche – INSERM

+33 (0)5 57 57 47 73

Site : Carreire

Organization and Adaptability of Motor Systems (Organisation et Adaptabilité des Systèmes Moteurs - OASM)
Motor system, neuronal network, respiration

Research interests:

  • CPG (central pattern generator)
  • Rhythmogenesis
  • Development

Scientific expertise:

  • Electrophysiology (field recording, visual patch clamp)
  • Calcium imaging


  • Development of the central respiratory command during the perinatal period

Selected Publications:

  • Thoby-Brisson M, Karlen M, Wu N, Charnay P, Champagnat J & Fortin G. (2009) Genetic identification of an embryonic parafacial oscillator coupling to the preBötzinger complex. Nature Neuroscience: 12, 1028-1035.
  • Dubreuil V, Thoby-Brisson M, Rallu M, Persson K, Pattyn A, Birchmeier C, Brunet JF, Fortin G & Goridis C. (2009) Defective respiratory rhythmogenesis and loss of central chemosensitivity in Phox2b mutants targeting retrotrapezoid nucleus neurons. Journal of Neuroscience: 29, 14836-14846.
  • Bouvier J, Thoby-Brisson M, Renier N, Dubreuil V, Ericson J, Champagnat J, Pierani A, Chédotal A & Fortin G. (2010) Hindbrain interneurons and axon guidance signaling critical for breathing. Nature Neuroscience: 13, 1066-1074.
  • Mellen NM & Thoby-Brisson M. (2012) Respiratory circuits: development, function and models. Current Opinion in Neurobiolgy: 22, 676-685.
  • Toporikova N, Chevalier M & Thoby-Brisson M. (2015) Sigh and eupnea rhythmogenesis involves distinct interconnected subnetworks: a combined computational and experimental study. eNeuro: 2, 0074-14.
  • Chevalier M, Toporikova N, Simmers J & Thoby-Brisson M. (2016) Development of pacemaker properties and rhythmogenic mechanisms in the mouse embryonic respiratory network. eLife: 5, e16125.
  • Lambert FM, Cardoit L, Courty E, Bougerol M, Thoby-Brisson M, Simmers J, Tostivint H & Le Ray D. (2018) Functional limb muscle innervation prior to cholinergic transmitter specification during early metamorphosis in Xenopus. eLife: 7, e30693.