Institut de Neurosciences Cognitives et Intégratives d'Aquitaine (UMR5287)

Aquitaine Institute for Cognitive and Integrative Neuroscience



INCIA - UMR 5287- CNRS
Université de Bordeaux

Zone nord Bat 2 2ème étage
146, rue Léo Saignat
33076 Bordeaux cedex
France

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Télécopie 05.56.90.14.21

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CNRS Ecole Pratique des Hautes Etudes Université de Bordeaux

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Thoby-Brisson Muriel

published on , updated on

DR2 INSERM, HDR, Team Co-leader

Contact:
muriel.thoby-brisson@u-bordeaux.fr

+33 (0)5 57 57 47 73

Site : CampusCarreire

Team:
Development and Neurobiology of Neural Networks

Social:

ORCID: 0000-0003-3214-1724

Domain:
Neural networks and rhythmic motor activity genesis/ Developmental ontogenesis of neural networks

Research axis:

  • Development of respiratory networks
  • Respiratory pathologies
  • Neural networks and rhythmogenesis

Scientific expertise:

  • Electrophysiology at the cellular, population and nerve roots levels
  • Functional imaging
  • Anatomy and immunostainings
  • Behavior analysis (breathing, locomotion)

Projects:

  • Embryonic development of the central respiratory command in normal and pathological conditions
  • Searching for a treatment in the context of Central Hypoventilation Congenital Syndrome (CCHS)
  • Development of the vestibular system

Collaborations:

  • Frédéric Brocard, INT, Marseille, France
  • Jorge Gallego, INSERM U1141, Hôpital Debré, Paris, France
  • Olivier Pascual, INMG, Lyon, France
  • Natalia Toporikova, Washington and Lee University, Lexington, USA
  • Nicholas Mellen, Louisville University, USA

Funding:

  • PhD CIFRE grant (115 k€; 2020-2023), Towards treating CCHS
  • Financial support from AtmosR (15 k€, 2021-2022), AFSO and Rotary Club (10 k€, 2019), Search for a therapeutical treatment against CCHS)
  • AFSO Grant for a post-doc (100 k€, 2018-2020), ATS002: a molecule against respiratory deficits in CCHS)
  • FRM "Equipe FRM" (2017-2020, 362k€), Physiology and physiopathology of developing sensory and motor brainstem circuits: implications for breathing, postural and locomotor behaviors.
  • ANR "RhythmDev" (2012-2016, 280 k€, PI; Partner: Drs Vinay/Brocard, Marseille), Embryonic development of rhythmogenic motor networks
  • PhD grant from Fond de Recherche en Santé Respiratoire (2011-2014); 98 k€, Embryonic development of the respiratory neural network

Selected publications:

  • Madani A, Pitollat G, Sizun E, Cardoit L, Ringot M, Bourgeois T, Ramanantsoa N, Delclaux C, Dauger S, d’Ortho MP, Thoby-Brisson M, Gallego J, Matrot B (2021) Obstructive apneas in a mouse model of congenital central hypoventilation syndrome. American Journal of Respiratory and critical care medicine 204:1200-1210.
  • Lambert FM, Cardoit L, Courty E, Bougerol M, Thoby-Brisson M, Simmers J, Tostivint H, Le Ray D (2018) Functional limb muscle innervation to cholinergic transmitter specification during early metamorphosis in Xenopus. eLife e30693.
  • Chevalier M, Toporikova N, Simmers J, Thoby-Brisson M (2016) Development of pacemaker properties and rhythmogenic mechanisms in the mouse embryonic respiratory network. eLife 16125.
  • Chapuis C, Autran S, Fortin G, Simmers J, Thoby-Brisson M (2014) Emergence of sigh rhythmogenesis in the embryonic mouse. Journal of Physiology (London) 592:2169-2181.
  • Mellen NM, Thoby-Brisson M. (2012) Respiratory circuits: development, function and models. Current Opinion in Neurobiology 22:676-685.
  • Ramanantsoa N, Hirsch MR, Thoby-Brisson M, Dubreuil V, Bouvier J, Ruffault PL, Matrot B, Fortin G, Brunet JF, Gallego J, Goridis C. (2011) Breathing without CO2 chemosensitivity in conditional Phox2b mutants. Journal of Neuroscience 31:12880-12888.
  • Bouvier J, Thoby-Brisson M, Renier N, Dubreuil V, Ericson J, Champagnat J, Pierani A, Chédotal A, Fortin G. (2010) Hindbrain interneurons and axon guidance signaling critical for breathing. Nature Neuroscience 13 :1066-1074.
  • Thoby-Brisson M, Karlen M, Wu N, Charnay P, Champagnat J, Fortin G. (2009) Genetic identification of an embryonic parafacial oscillator coupling to the preBötzinger complex. Nature Neuroscience 12:1028-1035.
  • Thoby-Brisson M, Trinh JB, Champagnat J, Fortin G (2005) Emergence of the pre-Bötzinger respiratory rhythm generator in the mouse embryo. Journal of Neuroscience 25:4307-4318.
  • Lieske SP, Thoby-Brisson M, Telgkamp P, Ramirez J-M. (2000) Reconfiguration of the neural network controlling multiple breathing patterns: eupnea, sighs and gasps. Nature Neuroscience 3:600-607.

Publications 1998-2021:

2021

  • Gotchac J, Cardoit L, Thoby-Brisson M, Brissaud O (2021) A rodent model of mild neonatal hypoxic ischemic encephalopathy. Frontiers in Neurology 12:637947.
  • Boulain M, Khisme I, Sourioux M, Thoby-Brisson M, Barrière G, Simmers J, Morin D, Juvin L (2021) Synergistic interaction between sensory inputs and propriospinal signaling underlying quadrupedal locomotion. J Physiol 599:4477-4496.
  • Madani A, Pitollat G, Sizun E, Cardoit L, Ringot M, Bourgeois T, Ramanantsoa N, Delclaux C, Dauger S, d’Ortho MP, Thoby-Brisson M, Gallego J, Matrot B (2021) Obstructive apneas in a mouse model of congenital central hypoventilation syndrome. American Journal of Respiratory and critical care medicine 204:1200-1210.

2020

  • Le Gal JP, Colnot E, Cardoit L, Bacqué-Caznave J, Thoby-Brisson M, Juvin L, Morin D (2020) Modulation of respiratory network activity by forelimb and hindlimb locomotor generators. European Journal of Neuroscience 52:3181-3195.

    2018

  • Lambert FM, Cardoit L, Courty E, Bougerol M, Thoby-Brisson M, Simmers J, Tostivint H, Le Ray D (2018) Functional limb muscle innervation to cholinergic transmitter specification during early metamorphosis in Xenopus. eLife e30693.
  • Nicolosi A, Cardoit L, Pasquereau P, Jaillet C, Thoby-Brisson M, Juvin L, Morin D (2018) Acute exposure to zinc nanoparticules critically disrupts operation of the respiratory neural network in neonatal rat. Neurotoxicology 67:150-160.
  • Thoby-Brisson M (2018) Neural mechanisms for sigh generation during prenatal development. Journal of Neurophysiology 120:1162-1172.
  • Dubois CJ, Cardoit L, Schwarz V, Markkanen M, Airaksinen MS, Uvarov P, Simmers J, Thoby-Brisson M (2018) Role of the K+-Cl- cotransporter KCC2a isoform in mammalian respiratory at birth. eNeuro 5:0264-18.

2017

  • Chevalier M, Cardoit L, Moreau M, Sans N, Montcouquiol M, Simmers J, Thoby-Brisson M (2017) The embryonic development of hindbrain respiratory networks is unaffected by mutation of the planar polarity protein Scribble. Neuroscience 357:160-171.

2016

  • Chevalier M, De Sa R, Cardoit L, Thoby-Brisson M (2016) Mechanisms underlying adaptation of respiratory network activity to modulatory stimuli in the mouse embryo. Neural Plasticity 2016:3905257.
  • Chevalier M, Toporikova N, Simmers J, Thoby-Brisson M (2016) Development of pacemaker properties and rhythmogenic mechanisms in the mouse embryonic respiratory network. eLife 16125.

2015

  • Bougerol M, Auradé F, Lambert F, Le Ray D, Combes D, Thoby-Brisson M, Relaix F, Pollet N, Tostivint H (2015) Generation of BAC transgenic tadpoles enabling live imaging of motoneurons by using the urotensin II-related peptide (ust2b) gene as a driver. Plos One 10:e0117370.
  • Toporikova N, Chevalier M, Thoby-Brisson M (2015) Sigh and eupnea rhythmogenesis involves distinct interconnected subnetworks: a combined computational and experimental study. eNeuro 0074-14.

2014

  • Le Gal JP, Juvin L, Cardoit L, Thoby-Brisson M, Morin D (2014) Remote control of respiratory neural network by spinal locomotor generators. Plos One 9:e89670.
  • Chapuis C, Autran S, Fortin G, Simmers J, Thoby-Brisson M (2014) Emergence of sigh rhythmogenesis in the embryonic mouse. Journal of Physiology (London) 592:2169-2181.

1998-2013

  • Thoby-Brisson M, Bouvier J, Glasco D, Stewart M, Dean C, Murdoch J, Champagnat J, Fortin G, Chandrasekhar A (2012) Brainstem Respiratory Oscillators Develop Independently of Neuronal Migration Defects in the Wnt/PCP Mutant looptail. Plos One 7:e31140.
  • Mellen NM, Thoby-Brisson M. (2012) Respiratory circuits: development, function and models. Current Opinion in Neurobiology 22:676-685.
  • Champagnat J, Morin-Surun MP, Bouvier J, Thoby-Brisson M, Fortin G. (2011) Prenatal development of central rhythm generation. Respiratory Physiology and Neurobiology 178:146-155.
  • Ramanantsoa N, Hirsch MR, Thoby-Brisson M, Dubreuil V, Bouvier J, Ruffault PL, Matrot B, Fortin G, Brunet JF, Gallego J, Goridis C. (2011) Breathing without CO2 chemosensitivity in conditional Phox2b mutants. Journal of Neuroscience 31:12880-12888.
  • Caubit X, Thoby-Brisson M, Voituron N, Filippi P, Bévengut M, Faralli H, Zanella S, Fortin G, Hilaire G, Fasano L. (2010) Teashirt3 regulates development of neurons involved in both respiratory rhythm and airflow control. Journal of Neuroscience 30:9465-9476.
  • Bouvier J, Thoby-Brisson M, Renier N, Dubreuil V, Ericson J, Champagnat J, Pierani A, Chédotal A, Fortin G. (2010) Hindbrain interneurons and axon guidance signaling critical for breathing. Nature Neuroscience 13 :1066-1074.
  • Goridis C, Dubreuil V, Thoby-Brisson M, Fortin G, Brunet JF. (2010) Phox2b, congenital central hypoventilation syndrome and the control of respiration. Seminar in Cell Developmental Biology 21:814-822.
  • Champagnat J, Thoby-Brisson M, Fortin G. (2010) Genetic factors determining the functional organization of neural circuits controlling rhythmic movements: the murine embryonic parafacial rhythm generator. Progress in Brain Research 187:39-46.
  • Champagnat J, Morin-Surun MP, Fortin G, Thoby-Brisson M. (2009) Developmental basis of the rostro-caudal organization of the brainstem respiratory rhythm generator. Philosophical Transactions of the Royal Society 364:2469-2476.
  • Fortin G, Thoby-Brisson M. (2009) Embryonic emergence of the respiratory rhythm generator. Respiratory Physiology and Neurobiology 168:86-91.
  • Thoby-Brisson M, Karlen M, Wu N, Charnay P, Champagnat J, Fortin G. (2009) Genetic identification of an embryonic parafacial oscillator coupling to the preBötzinger complex. Nature Neuroscience 12:1028-1035.
  • Dubreuil V*, Thoby-Brisson M*, Rallu M, Persson K, Pattyn A, Birchmeier C, Brunet JF, Fortin G, Goridis C. (2009) Defective respiratory rhythmogenesis and loss of central chemosensitivity in Phox2b mutants targeting retrotrapezoid nucleus neurons. Journal of Neuroscience 29:14836-14846.
  • Thoby-Brisson M, Greer JJ. (2008) Anatomical and functional development of the pre-Bötzinger complex in prenatal rodents. Journal of Applied Physiology 104:1213-1219.
  • Tryba AK, Pena F, Lieske SP, Viemari JC, Thoby-Brisson M, Ramirez JM. (2008) Differential modulation of neural network and pacemaker activity underlying eupnea and sigh breathing activities. Journal of Neurophysiology 99:2114-2125.
  • Bouvier J, Autran S, Dehorter N, Katz DM, Champagnat J, Fortin G, Thoby-Brisson M. (2008) BDNF enhances fetal respiratory rhythm frequency in the mouse pre-Bötzinger complex in vitro. European Journal of Neuroscience 28:510-520.
  • Wrobel LJ, Ogier M, Chatonnet F, Autran S, Mezières V, Thoby-Brisson M, McLean H, Taeron C, Champagnat J. (2007) Abnormal inspiratory depth in Phox2a haploinsufficient mice. Neuroscience 145:384-392.
  • Chatonnet F, Borday C, Wrobel L, Thoby-Brisson M, Fortin G, McLean H, Champagnat J. (2006) Ontogeny of central rhythm generation in chicks and rodents. Respiratory Physiology and Neurobiology 154:37-46.
  • Masson J, Darmon M, Conjard A, Chuhma N, Ropert N, Thoby-Brisson M, Foutz AS, Parrot S, Miller GM, Jorisch R, Polan J, Hamon M, Hen R, Rayport S (2006) Mice lacking brain/kidney phosphate-activated glutaminase have impaired glutamatergic synaptic transmission, altered breathing, disorganized goal-directed behavior and die shortly after birth. Journal of Neuroscience 26:4660-4671.
  • Wallen-McKenzie A, Gezelius H, Thoby-Brisson M, Nygard A, Enjin A, Fujiyama F, Fortin G, Kullander K (2006) VGLUT2 is required for central respiratory rhythm but not for locomotor central pattern generation. Journal of Neuroscience 26:12294-12307.
  • Bouvier J, Autran S, Fortin G, Champagnat J, Thoby-Brisson M (2006) Acute role of the brain-derived neurotrophic factor (BDNF) on the respiratory neural network activity in vitro in mice. Journal of Physiology (Paris) 100:290-296.
  • Borday C, Vias C, Autran S, Thoby-Brisson M, Champagnat J, Fortin G (2006) The pre-Bötzinger oscillator in the mouse embryo. Journal of Physiology (Paris) 100:284-289.
  • Thoby-Brisson M, Trinh JB, Champagnat J, Fortin G (2005) Emergence of the pre-Bötzinger respiratory rhythm generator in the mouse embryo. Journal of Neuroscience 25:4307-4318.
  • Borday C, Chatonnet F, Thoby-Brisson M, Champagnat J, Fortin G (2005) Neural tube patterning by Krox20 and emergence of a respiratory control. Respiratory Physiology and Neurobiology 149:63-72.
  • Borday C, Wrobel L, Fortin G, Champagnat J, Thaëron-Antôno C, Thoby-Brisson M (2004) Developmental gene control of brainstem function: views from embryo. Progress in Biophysics and Molecular Biology 84:89-106.
  • Thoby-Brisson M, Autran S, Fortin G, Champagnat J (2004) BDNF preferentially targets membrane properties of rhythmically active neurons in the pre-Botzinger complex in neonatal mice. Advance in experimental medicine and biology 551:115-120.
  • - Borday C, Abadie V, Chatonnet F, Thoby-Brisson M, Champagnat J, Fortin G (2003) Developmental molecular switches regulating breathing patterns in CNS. Respiratory Physiology and Neurobiology 135:121-132.
  • Thoby-Brisson M, Cauli B, Champagnat J, Fortin G, Katz DM (2003) Expression of functional tyrosine kinase B receptors by rhythmically active respiratory neurons in the pre-Botzinger complex of neonatal mice. Journal of Neuroscience 23:7685-7689.
  • Champagnat J, Denavit-Saubie M, Fortin G, Foutz AS, Antôno-Thaëron C, Thoby-Brisson M (2003) Emergence of neural net function during brain develoment. Journal of Physiology (Paris) 97:1-3.
  • Chatonnet F, Dominguez del Toro E, Thoby-Brisson M, Champagnat J, Fortin G, Rijli FM, Thaëron-Antôno C (2003) From hindbrain segmentation to breathing after birth: developmental patterning in rhombomeres 3 and 4. Molecular Neurobiology 28:277-294.
  • Thoby-Brisson M, Simmers J (2002) Long-term neuromodulatory regulation of a motor pattern-generating network: maintenance of synaptic efficacy and oscillatory properties. Journal of Neurophysiology 88:2942-2953.
  • Chatonnet F, Thoby-Brisson M, Abadie V, Dominguez del Toro E, Champagnat J, Fortin G (2002) Early development of respiratory rhythm generation in mouse and chick. Respiratory Physiology and Neurobiology 131:5-13.
  • Thoby-Brisson M, Ramirez J-M (2001) Identification of two types of bursts generated in inspiratory pacemaker neurons in the isolated respiratory network of mice. Journal of Neurophysiology 86:104-112.
  • Lieske SP, Thoby-Brisson M, Ramirez J-M (2001) Reconfiguration of the central respiratory network under normoxic and hypoxic conditions. Advance in experimental medicine and biology 499:171-178.
  • Thoby-Brisson M, Simmers J (2000) Transition to endogenous bursting after long-term decentralization requires de novo transcription in a critical time window. Journal of Neurophysiology 84:596-599. -* Thoby-Brisson M, Telgkamp P, Ramirez J-M (2000) The role of the hyperpolarization-activated current in modulating rhythmic activity in the isolated respiratory network of mice. Journal of Neuroscience 20:2994-3005. -* Lieske SP, Thoby-Brisson M, Telgkamp P, Ramirez J-M (2000) Reconfiguration of the neural network controlling multiple breathing patterns: eupnea, sighs and gasps. Nature Neuroscience 3:600-607. -* Thoby-Brisson M, Ramirez J-M (2000) Role of inspiratory pacemaker neurons in mediating the hypoxic response of the respiratory network in vitro. Journal of Neuroscience 20:5858-5866.
  • Thoby-Brisson M, Simmers J (1998) Neuromodulatory inputs maintain expression of a lobster motor pattern-generating network in a modulation-dependent state: evidence from longterm decentralization in vitro. Journal of Neuroscience 18:2212-2225.