Institut de Neurosciences Cognitives et Intégratives d'Aquitaine (UMR5287)

Aquitaine Institute for Cognitive and Integrative Neuroscience



INCIA - UMR 5287- CNRS
Université de Bordeaux

Zone nord Bat 2 2ème étage
146, rue Léo Saignat
33076 Bordeaux cedex
France

Téléphone 05.57.57.15.51
Télécopie 05.56.90.14.21

Supervisory authorities

CNRS Ecole Pratique des Hautes Etudes Université de Bordeaux

Our partners

Neurocampus Unitéde Formation de Biologie

GDR

GDR Robotique GDR Mémoire GDR Multi-électrodes

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Le Moine Catherine

by Catherine Le Moine - published on , updated on

Catherine Le Moine DR2 CNRS

Contact:
[catherine.le-moine@u-bordeaux.fr]
Twitter / ORCID / LinkedIn

Bibliometry:
Publons WOS
Google Scholar

Site : Charles Perrens

Team:
Decision and Adaptation

Domain: Animal cognition and behaviour/ Associative Learning

Research axis:
Neuronal representations of aversive emotional memories in the brain

Scientific expertise:

  • Physiopathology of cellular interactions involving dopamine transmission in basal ganglia
  • Opiate dependence and withdrawal: Behaviour and neural substrates of associated aversive memories.
  • Neural bases of associative learning
  • Functional neuroanatomy and cellular imaging in cortico-subcortical circuits
  • In vivo Electrophysiology

Projects:

  • Dynamic acquisition and expression of the aversive memory of withdrawal in opiate dependence (pathological). Comparison with fear encoding (physiological).
  • Plasticity and neuronal reactivity for the formation and retrieval of aversive emotional memories.
  • Neurobiological substrates of behavioral adaptation

Selected Publications from 2010

  • Noe E, Bonneau N, Fournier ML, Caillé-Garnier S, Cador M, Le Moine C (2019) Arc reactivity in accumbens nucleus, amygdala and hippocampus differentiates cue over context responses during reactivation of opiate withdrawal memory. Neurobiology of Learning and Memory (in press)
  • Gueye AB, Vendruscolo LF, de Ávila C, Le Moine C, Darnaudéry M, Cador M. (2018) Unlimited sucrose consumption during adolescence generates a depressive-like phenotype in adulthood. Neuropsychopharmacology. doi: 10.1038/s41386-018-0025-9.
  • Fitoussi A, Renault P, Le Moine C, Coutureau E, Cador M, Dellu-Hagedorn F (2018) Inter-individual differences in decision-making, flexible and goal-directed behaviors: novel insights within the prefronto-striatal networks. Brain Structure & Function. 223:897-912.
  • Dejean C, Sitko M, Girardeau P, Bennabi A, Caillé S, Cador M, Boraud T, Le Moine C. (2017) Memories of opiate withdrawal emotional states correlate with specific gamma oscillations in the nucleus accumbens. Neuropsychopharmacology 42, 1157–1168
  • Hachem-Delaunay S, Fournier ML, Cohen C, Bonneau N, Cador M, Baunez C, Le Moine C. (2015) Subthalamic nucleus high frequency stimulation modulates neuronal reactivity to cocaine within the reward circuit Neurobiology of Disease, 80, 54–62
  • Fitoussi A, Le Moine C, De Deurwaerdere P, Laqui M, Rivalan M, Cador M, Dellu-Hagedorn F. (2015) Prefronto-subcortical imbalance characterizes poor decision-making: neurochemical and neural functional evidences in rats? Brain Structure and Function, 230, 3485-3496.
  • Dejean C, Boraud T & Le Moine C (2013) Opiate dependence induces network state shifts in the limbic system. Neurobiology of Disease 59, 220-229
  • Ingallinesi M, Rouibi K, Le Moine C, Papaleo F & Contarino A (2012) CRF2 receptor-deficiency eliminates opiate withdrawal distress without impairing stress coping. Molecular Psychiatry 17, 1283-1294.
  • Lucas M, Frenois F, Cador M & Le Moine C (2012) Remodeling of the neuronal circuits underlying opiate-withdrawal memories following remote retrieval. Neurobiology of Learning and Memory 97, 47-53.
  • Dejean C, Arbuthnott G, Wickens JR, Le Moine C, Boraud T, Hyland BI (2011) Power fluctuations in beta and gamma frequencies in rat globus pallidus: association with specific phases of slow oscillations and differential modulation by dopamine D1 and D2 receptors. J Neurosci 31:6098-6107.

Fundings as PI

  • ANR PROGRAMME BLANC MEMOPIATE (2010-2014) “Affective memories associated with opiate withdrawal: neural substrates and potential role in addiction” (PI: C Le Moine, INCIA, Bordeaux; Partner: T Boraud, IMN, Bordeaux). 500 K€, 4 years.
  • AO FRM –- Engineer position for Innovative project (2013-2015) “Neural Networks and synchronization in addiction” 80 K€ (salary), 2 years
  • AO FRM Physiopathologie de l’Addiction (2014-2018) “Affective memories in drug addiction: differentiation of context versus CS effects in the coding and retrieval of opiate withdrawal memories” (PI: C Le Moine, INCIA, Bordeaux; Partner: T Boraud, IMN, Bordeaux). 220 K€, 3 years
  • Labex Brain Seed Project 2021 “Neuronal representation of aversive emotional memories in the PFC-BLA circuit: biomimetic theoretical modelling and oscillatory dynamics” (PI: C Le Moine, INCIA, Bordeaux; Partner: A Leblois, IMN, Bordeaux). 20 K€, 1 year