Institut de Neurosciences Cognitives et Intégratives d'Aquitaine (UMR5287)

Aquitaine Institute for Cognitive and Integrative Neuroscience

Université de Bordeaux

Zone nord Bat 2 2ème étage
146, rue Léo Saignat
33076 Bordeaux cedex


Supervisory authorities

CNRS Ecole Pratique des Hautes Etudes Université de Bordeaux

Our partners

Neurocampus Unitéde Formation de Biologie


GDR Robotique GDR Mémoire GDR Multi-électrodes


Home > Directory

Caillé-Garnier Stéphanie

by Catherine Le Moine - published on , updated on

Stéphanie Caillé-Garnier CR1 CNRS

+33 (0)5 57 57 15 63

Site : Charles Perrens


Behavioral and Neuropharmacological Neurosciences

Consequences of chronic exposure to drugs of abuse: profil of a persistant pathology. Role of the endocannabinoid system in the addictive properties of drugs.

Research axis:

  • Neurological and psychiatric conditions
  • Addiction and Drugs of Abuse
  • Motivation and emotion
  • Animal cognition and behavior
  • Behavioral pharmacology
  • Neurobiology

Scientific expertise:

  • Animal behavior
  • Animal models of addiction
  • Opiate dependence
  • Animal models of Stress “ Anxiety “ Depression
  • Neurobiology of the extend amygdala, the mesocorticolimbic dopaminergic system, and the endocannabinoid system


  • Behavioral and neurobiological characterization of the protracted abstinence state in rat with drug exposure either in adolescence or in adulthood
  • Decision-making and vulnerability to nicotine or cocaine addiction (Collaboration with Françoise Dellu-Hagedorn et Martine Cador)
  • The endocannabinoid system in nicotine addiction
  • Electrophysiological study of the mesolimbic dopaminergic system in nicotine addiction: involvement of endocannabinoid and Glutamatergic transmissions (Collaboration with François Georges, IINES)
  • Aversive memories associated with opiate withdrawal and drug seeking (Collaboration with Catherine Le Moine, Thomas Boraud and Martine Cador)



Selected Publications:

  • Glangetas C, Massi L, Fois GR, Jalabert M, Girard D, Diana M, Yonehara K, Roska B, Xu C, Luthi A, Caillé S, Georges F (2017) NMDA-receptor-dependent plasticity in the bed nucleus of the stria terminalis triggers long-term anxiolysis. Nature Communications 8:14456.
  • Dejean C, Sitko M, Girardeau P, Bennabi A, Caillé S, Cador M, Boraud T, Le Moine C (2017) Memories of opiate withdrawal emotional states correlate with specific gamma oscillations in the nucleus accumbens. Neuropsychopharmacology 42:1157-1168.
  • Simonnet A, Zamberletti E, Cador M, Rubino T, Caillé S (2017) Chronic FAAH inhibition during nicotine abstinence alters habenular CB1 receptor activity and precipitates depressive-like behaviors, Neuropharmacology. 113:252-259.
  • Romani Perez M, Lépinay M, Alonso L, Rincel M, Xia L, Fanet H, Caillé S, Cador M, Laye S, Vancassel S, Darnaudery M (2016) Impact of a maternal high fat diet and maternal separation on energy homeostasis and food-motivated behavior, Int J Obesity 41 : 502-509.
  • Glangetas C, Fois GR, Jalabert M, Lecca S, Valentinova K, Meye FJ, Diana M, Faure P, Mameli M, Caille S, Georges F (2015) Ventral Subiculum Stimulation Promotes Persistent Hyperactivity of Dopamine Neurons and Facilitates Behavioral Effects of Cocaine. Cell reports 13:2287-2296.
  • Reisiger AR, Kaufling J, Manzoni O, Cador M, Georges F & Caille S (2014) Nicotine self-administration induces CB1-dependent LTP in the bed nucleus of the stria terminalis. J Neurosci 34, 4285-92.
  • Simonnet A, Cador M & Caille S (2013) Nicotine reinforcement is reduced by cannabinoid CB1 receptor blockade in the ventral tegmental area. Addiction Biology 18, 930-936.
  • Caille S, Clemens K, Stinus L & Cador M (2012) Modeling nicotine addiction in rats. Methods in molecular biology (Clifton, N.J.) 829, 243-56.
  • Clemens KJ, Caille S, Cador M (2010) The effects of response operandum and prior food training on intravenous nicotine self-administration in rats. Psychopharmacology (Berl) 211:43-54.
  • Caille S, Guillem K, Cador M, Manzoni O, Georges F (2009) Voluntary nicotine consumption triggers in vivo potentiation of cortical excitatory drives to midbrain dopaminergic neurons. J Neurosci 29:10410-10415.
  • Clemens KJ, Caille S, Stinus L, Cador M (2009) The addition of five minor tobacco alkaloids increases nicotine-induced hyperactivity, sensitization and intravenous self-administration in rats. Int J Neuropsychopharmacol 12:1355-1366.
  • Caille S, Alvarez-Jaimes L, Polis I, Stouffer DG, Parsons LH (2007) Specific alterations of extracellular endocannabinoid levels in the nucleus accumbens by ethanol, heroin, and cocaine self-administration. J Neurosci 27:3695-3702.
  • Caille S, Parsons LH (2006) Cannabinoid modulation of opiate reinforcement through the ventral striatopallidal pathway. Neuropsychopharmacology 31:804-813.
  • Georges F, Caille S, Vouillac C, Le Moine C, Stinus L (2005) Role of imidazoline receptors in the anti-aversive properties of clonidine during opiate withdrawal in rats. Eur J Neurosci 22:1812-1816.
  • Caille S, Parsons LH (2004) Intravenous heroin self-administration decreases GABA efflux in the ventral pallidum: an in vivo microdialysis study in rats. Eur J Neurosci 20:593-596.
  • Caille S, Parsons LH (2003) SR141716A reduces the reinforcing properties of heroin but not heroin-induced increases in nucleus accumbens dopamine in rats. Eur J Neurosci 18:3145-3149.
  • Caille S, Rodriguez-Arias M, Minarro J, Espejo EF, Cador M, Stinus L (2003a) Changes in dopaminergic neurotransmission do not alter somatic or motivational opiate withdrawal-induced symptoms in rats. Behav Neurosci 117:995-1005.
  • Caille S, Stinus L, Espejo EF, De Deurwaerdere P, Spampinato U, Koob GF (2003b) Inhibition of 5-HT neurotransmission increases clonidine protective effects on naloxone-induced conditioned place aversion in morphine-dependent rats. Neuropsychopharmacology 28:276-283.
  • Caille S, Espejo EF, Koob GF, Stinus L (2002) Dorsal and median raphe serotonergic system lesion does not alter the opiate withdrawal syndrome. Pharmacol Biochem Behav 72:979-986.
  • Frenois F, Cador M, Caille S, Stinus L, Le Moine C (2002) Neural correlates of the motivational and somatic components of naloxone-precipitated morphine withdrawal. Eur J Neurosci 16:1377-1389.
    - Espejo EF, Serrano MI, Caille S, Stinus L (2001) Behavioral expression of opiate withdrawal is altered after prefrontocortical dopamine depletion in rats: monoaminergic correlates. Neuropsychopharmacology 25:204-212.
  • Stinus L, Caille S, Koob GF (2000) Opiate withdrawal-induced place aversion lasts for up to 16 weeks. Psychopharmacology (Berl) 149:115-120.
  • Caille S, Espejo EF, Reneric JP, Cador M, Koob GF, Stinus L (1999) Total neurochemical lesion of noradrenergic neurons of the locus ceruleus does not alter either naloxone-precipitated or spontaneous opiate withdrawal nor does it influence ability of clonidine to reverse opiate withdrawal. J Pharmacol Exp Ther 290:881-892.


  • ANR Programme Blanc 2009-2013, project « Memopiate » (Principal investigator C Le Moine, collaborators T Boraud, M Cador, S Caillé-Garnier).
  • ANR Programme Blanc 2010-2013, project « Nicoplastic » (Principal investigator S Caillé-Garnier, Collaborator F Georges)