CR1 CNRS
Contact:
[stephanie.caille-garnier@u-bordeaux.fr]
+33 (0)5 57 57 15 63
LinkedIn / Google Scholar / Twitter
ORCID: http://orcid.org/0000-0002-4906-3091
Site : Charles Perrens
Team: Emotion, Motivation, Cognition (EMOTIV)
Domain: Behavioral and Neuropharmacological Neurosciences
Theme:
- Consequences of chronic exposure to drugs of abuse: profil of a persistant pathology
- Role of the endocannabinoid system in the addictive properties of drugs
Research axis:
- Neural and Behavioral vulnerability to drug addiction
- Multidimensional behavioral determinants of addiction
Scientific expertise:
- Rodent models of addiction (classical i.v. self-administration)
- “E-cig Vaping” model in mice
- Emotion, Motivation and Cognition in rodents
- Probing neural circuits during behaviors
Projects:
- E-cig modelling in mice: identification of behavioral and neural (dopamine, olfactory system) vulnerability
- Attentional control, prefrontal cholinergic control and predictability of vulnerability to nicotine addiction
- Nicotine exposure during adolescence and protracted effects at adulthood
Grants:
- ANR Programme Blanc 2009-2013, project « Memopiate » (Principal investigator C Le Moine, collaborators T Boraud, M Cador, S Caillé-Garnier).
- ANR Programme Blanc 2010-2013, project « Nicoplastic » (Principal investigator S Caillé-Garnier, Collaborator F Georges)
Selected Publications:
- Impact of acute and chronic nicotine administration on midbrain dopaminergic neuron activity and related behaviours in TRPV1 knock-out juvenile mice. Allain AE, Aribo O, Medrano MC, Fournier ML, Bertrand SS and Caillé S. (2022). Eur J Neurosci. 55(3):697-713
- Flavor additives facilitate oral self-administration of nicotine solution in mice. Tannous S, Darlot F, Cador M and Caillé S. (2021) Psychopharmacol., 1-13. 10.1007/s00213-021-05848-1
- Arc reactivity in accumbens nucleus, amygdala and hippocampus differentiates cue over context responses during reactivation of opiate withdrawal memory. Noe E, Bonneau N, Fournier ML, Caillé S*, Cador M*, Le Moine C*. (2019) Neurobiol Learn Mem. 2019 Mar;159:24-35. doi: 10.1016/j.nlm.2019.02.007. Epub 2019 Feb 13. *equally contributed
- Attentional capacities prior to drug exposure predict motivation to self-administer nicotine. Vandaele Y, Noe E, Cador M, Dellu-Hagedorn F, Caillé S. (2018) Psychopharmacology (Berl). 2018 Jul;235(7):2041-2050. doi: 10.1007/s00213-018-4901-0. Epub 2018 Apr 27.
- NMDA-receptor-dependent plasticity in the bed nucleus of the stria terminalis triggers long-term anxiolysis. Glangetas C, Massi L, Fois GR, Jalabert M, Girard D, Diana M, Yonehara K, Roska B, Xu C, Lüthi A, Caille S, Georges F. (2017) Nat Commun. Feb 20;8:14456. doi: 10.1038/ncomms14456.
- Chronic FAAH inhibition during nicotine abstinence alters habenular CB1 receptor activity and precipitates depressive-like behaviors. Simonnet A, Zamberletti E, Cador M, Rubino T, Caillé S. (2017) Neuropharmacology. Feb; 113(Pt A):252-259. doi: 10.1016/j.neuropharm.2016.10.007.
- Nicotine self- administration permits the induction of CB1-dependent LTP in the Bed Nucleus of the Stria Terminalis. Reisiger AR, Kaufling J, Cador M, Manzoni M, Georges F and Caillé S (2014) J Neurosci. Mar 19; 34(12):4285-92
- Modeling nicotine addiction in rats. Caillé S, Clemens K, Stinus L, Cador M. (2012) Methods Mol Biol. 829: 243-56. Review
- Voluntary nicotine consumption triggers in vivo potentiation of cortical excitatory drives to midbrain dopaminergic neurons Caillé S, Guillem K, Cador M, Manzoni OJ and Georges F. (2009). J Neurosci, 29(33):10410-5.