CR1 CNRS
Contact:
[stephanie.garnier@u-bordeaux2.fr]
+33 (0)5 57 57 15 63
Site : Charles Perrens
Team:
Addicteam
Domain:
Behavioral and Neuropharmacological Neurosciences
Theme:
Consequences of chronic exposure to drugs of abuse: profil of a persistant pathology. Role of the endocannabinoid system in the addictive properties of drugs.
Research axis:
- Neurological and psychiatric conditions
- Addiction and Drugs of Abuse
- Motivation and emotion
- Animal cognition and behavior
- Behavioral pharmacology
- Neurobiology
Scientific expertise:
- Animal behavior
- Animal models of addiction
- Opiate dependence
- Animal models of Stress “ Anxiety “ Depression
- Neurobiology of the extend amygdala, the mesocorticolimbic dopaminergic system, and the endocannabinoid system
Projects:
- Behavioral and neurobiological characterization of the protracted abstinence state in rat with drug exposure either in adolescence or in adulthood
- Decision-making and vulnerability to nicotine or cocaine addiction (Collaboration with Françoise Dellu-Hagedorn et Martine Cador)
- The endocannabinoid system in nicotine addiction
- Electrophysiological study of the mesolimbic dopaminergic system in nicotine addiction: involvement of endocannabinoid and Glutamatergic transmissions (Collaboration with François Georges, IINES)
- Aversive memories associated with opiate withdrawal and drug seeking (Collaboration with Catherine Le Moine, Thomas Boraud and Martine Cador)
ORCID
: http://orcid.org/0000-0002-4906-3091
Selected Publications:
- Glangetas C, Massi L, Fois GR, Jalabert M, Girard D, Diana M, Yonehara K, Roska B, Xu C, Luthi A, Caillé S, Georges F (2017) NMDA-receptor-dependent plasticity in the bed nucleus of the stria terminalis triggers long-term anxiolysis. Nature Communications 8:14456.
- Dejean C, Sitko M, Girardeau P, Bennabi A, Caillé S, Cador M, Boraud T, Le Moine C (2017) Memories of opiate withdrawal emotional states correlate with specific gamma oscillations in the nucleus accumbens. Neuropsychopharmacology 42:1157-1168.
- Simonnet A, Zamberletti E, Cador M, Rubino T, Caillé S (2017) Chronic FAAH inhibition during nicotine abstinence alters habenular CB1 receptor activity and precipitates depressive-like behaviors, Neuropharmacology. 113:252-259.
- Romani Perez M, Lépinay M, Alonso L, Rincel M, Xia L, Fanet H, Caillé S, Cador M, Laye S, Vancassel S, Darnaudery M (2016) Impact of a maternal high fat diet and maternal separation on energy homeostasis and food-motivated behavior, Int J Obesity 41 : 502-509.
- Glangetas C, Fois GR, Jalabert M, Lecca S, Valentinova K, Meye FJ, Diana M, Faure P, Mameli M, Caille S, Georges F (2015) Ventral Subiculum Stimulation Promotes Persistent Hyperactivity of Dopamine Neurons and Facilitates Behavioral Effects of Cocaine. Cell reports 13:2287-2296.
- Reisiger AR, Kaufling J, Manzoni O, Cador M, Georges F & Caille S (2014) Nicotine self-administration induces CB1-dependent LTP in the bed nucleus of the stria terminalis. J Neurosci 34, 4285-92.
- Simonnet A, Cador M & Caille S (2013) Nicotine reinforcement is reduced by cannabinoid CB1 receptor blockade in the ventral tegmental area. Addiction Biology 18, 930-936.
- Caille S, Clemens K, Stinus L & Cador M (2012) Modeling nicotine addiction in rats. Methods in molecular biology (Clifton, N.J.) 829, 243-56.
- Clemens KJ, Caille S, Cador M (2010) The effects of response operandum and prior food training on intravenous nicotine self-administration in rats. Psychopharmacology (Berl) 211:43-54.
- Caille S, Guillem K, Cador M, Manzoni O, Georges F (2009) Voluntary nicotine consumption triggers in vivo potentiation of cortical excitatory drives to midbrain dopaminergic neurons. J Neurosci 29:10410-10415.
- Clemens KJ, Caille S, Stinus L, Cador M (2009) The addition of five minor tobacco alkaloids increases nicotine-induced hyperactivity, sensitization and intravenous self-administration in rats. Int J Neuropsychopharmacol 12:1355-1366.
- Caille S, Alvarez-Jaimes L, Polis I, Stouffer DG, Parsons LH (2007) Specific alterations of extracellular endocannabinoid levels in the nucleus accumbens by ethanol, heroin, and cocaine self-administration. J Neurosci 27:3695-3702.
- Caille S, Parsons LH (2006) Cannabinoid modulation of opiate reinforcement through the ventral striatopallidal pathway. Neuropsychopharmacology 31:804-813.
- Georges F, Caille S, Vouillac C, Le Moine C, Stinus L (2005) Role of imidazoline receptors in the anti-aversive properties of clonidine during opiate withdrawal in rats. Eur J Neurosci 22:1812-1816.
- Caille S, Parsons LH (2004) Intravenous heroin self-administration decreases GABA efflux in the ventral pallidum: an in vivo microdialysis study in rats. Eur J Neurosci 20:593-596.
- Caille S, Parsons LH (2003) SR141716A reduces the reinforcing properties of heroin but not heroin-induced increases in nucleus accumbens dopamine in rats. Eur J Neurosci 18:3145-3149.
- Caille S, Rodriguez-Arias M, Minarro J, Espejo EF, Cador M, Stinus L (2003a) Changes in dopaminergic neurotransmission do not alter somatic or motivational opiate withdrawal-induced symptoms in rats. Behav Neurosci 117:995-1005.
- Caille S, Stinus L, Espejo EF, De Deurwaerdere P, Spampinato U, Koob GF (2003b) Inhibition of 5-HT neurotransmission increases clonidine protective effects on naloxone-induced conditioned place aversion in morphine-dependent rats. Neuropsychopharmacology 28:276-283.
- Caille S, Espejo EF, Koob GF, Stinus L (2002) Dorsal and median raphe serotonergic system lesion does not alter the opiate withdrawal syndrome. Pharmacol Biochem Behav 72:979-986.
- Frenois F, Cador M, Caille S, Stinus L, Le Moine C (2002) Neural correlates of the motivational and somatic components of naloxone-precipitated morphine withdrawal. Eur J Neurosci 16:1377-1389.
Espejo EF, Serrano MI, Caille S, Stinus L (2001) Behavioral expression of opiate withdrawal is altered after prefrontocortical dopamine depletion in rats: monoaminergic correlates. Neuropsychopharmacology 25:204-212. - Stinus L, Caille S, Koob GF (2000) Opiate withdrawal-induced place aversion lasts for up to 16 weeks. Psychopharmacology (Berl) 149:115-120.
- Caille S, Espejo EF, Reneric JP, Cador M, Koob GF, Stinus L (1999) Total neurochemical lesion of noradrenergic neurons of the locus ceruleus does not alter either naloxone-precipitated or spontaneous opiate withdrawal nor does it influence ability of clonidine to reverse opiate withdrawal. J Pharmacol Exp Ther 290:881-892.
Grants:
- ANR Programme Blanc 2009-2013, project « Memopiate » (Principal investigator C Le Moine, collaborators T Boraud, M Cador, S Caillé-Garnier).
- ANR Programme Blanc 2010-2013, project « Nicoplastic » (Principal investigator S Caillé-Garnier, Collaborator F Georges)