Institut de Neurosciences Cognitives et Intégratives d'Aquitaine (UMR5287)

Aquitaine Institute for Cognitive and Integrative Neuroscience

Université de Bordeaux

Zone nord Bat 2 2ème étage
146, rue Léo Saignat
33076 Bordeaux cedex


Supervisory authorities

CNRS Ecole Pratique des Hautes Etudes Université de Bordeaux

Our partners

Neurocampus Unitéde Formation de Biologie


GDR Robotique GDR Mémoire GDR Multi-électrodes


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Dellu-Hagedorn Françoise

by Francoise Dellu-Hagedorn - published on , updated on


+33 (0)5 57 57 46 19

Site : Carreire

MOCOCO: Motor Control and Cognition

Cognitive and behavioral neuroscience

Executive functions and behavioral traits related to neurodevelopmental disorders

Research axis:

  • Neurodevelopmental disorders
  • Cognition and behavior
  • Motivation and emotion
  • Decision-making and executive functions
  • Behavioural pharmacology
  • Neurobiology

Scientific expertise:

  • Dimensional approach for the study of neurodevelomental disorders and related dysfunctions (ADHD, impulsivity, inflexible behavior, poor decision-making, poor working memory)
  • Inter-individual differences in executive functions and behavior
  • Behavioral traits and related neurobiological inter-individual differences in neural network activation during behavior
  • Identification of neural signatures of behavioral traits through monoamine basal levels and metabolisms
  • Validation of cognitive tasks of impulsivity, decision-making


  • Specific neurodevelopmental learning disorders: the role of sensorimotor mechanisms.
  • Characterisation of behavioral traits associated with poor decision-making and identification of risk-factors for developing addiction to drug (cocaïne, nicotine), coll. with M. Cador and S. Caillé Garnier (addicteam).
  • Behavioral and neurobiological characterization of the protracted abstinence state in rat with drug exposure either in adolescence or in adulthood
  • Functional and dynamical organization of the networks involved in good vs poor decision-making by functional imaging (c-fos, zif) (coll. C. Le Moine, addicteam) and neurochemical correlates of these differences (monoaminergic systems) (coll. P. de Dewaerdere, IMN, Univ Bordeaux)

Selected Publications:

  • Vandaele Y., Noe E., Cador M., Caillé S.* and Dellu-Hagedorn F.* (*equal contribution) (2018) Attentional capacities prior to drug exposure predict motivation to self-administer nicotine. Psychopharmacology 235: 2041–2050. https://doi-org/10.1007/s00213-018-4901-0
  • De Deurwaedere P.*, Rivalan M., Fitoussi A. and Dellu-Hagedorn F.*(*equal contribution) (2018) Inter-individual differences in the impulsive/compulsive dimension: deciphering related dopaminergic and serotonergic metabolisms at rest. Phil. Trans. R. Soc. B, 373: 1-15.
  • Dellu-Hagedorn F., Fitoussi A. and De Deurwaedere P. (2017) Correlative analysis of dopaminergic and serotonergic metabolism across the brain to study monoaminergic function and interaction. J Neurosci Meth 280: 54-63.
  • Fitoussi A., Renault P., Le Moine C., Coutureau E., Cador M. and Dellu-Hagedorn F. (2017) Inter-individual differences in decision-making, flexible and goal-directed behaviors: novel insights within the prefronto-striatal networks. Brain Struct Funct, 223: 897-912..
  • Fitoussi A, Le Moine C, De Deurwaerdere P, Laqui M, Rivalan M, Cador M and Dellu-Hagedorn (2015) Prefronto-subcortical imbalance characterizes poor decision-making: neurochemical and neural functional evidences in rats. Brain Struct Funct, 222: 3485-3496.
  • Rivalan M, Valton V., Seriès P., Marchand A. and Dellu-Hagedorn F. (2013) Elucidating poor decision making in a rat gambling task.Plos One, 8(12):e82052.
  • Fitoussi A, De Deurwaerdere P. and Dellu-Hagedorn F. (2013) Monoamines tissue measurement reveals specific and restricted correlations of their content in some brain regions involved in cognition. Neuroscience, 255: 233-245.
  • Van Den Bos R, Davies W, Dellu-Hagedorn F, Goudriaan A, Granon S, Homberg J, Rivalan M, Swendsen J and Adriani W. (2013) Cross-species approaches to pathological gambling: a review targeting sex differences, adolescence and ecological validity of research tools. Neuroscience and Biobehavioral reviews 37: 2454–2471.
  • Pittaras E, Cressant A, Serreau P, Bruijel J, Dellu-Hagedorn F, Callebert J, Rabat A. and Granon S. (2013) Mice Gamble for Food: Individual Differences in Risky Choices and Prefrontal Cortex Serotonin. J Addict Res Ther S4: 011.
  • Rivalan M, Grégoire S, Le Moine C and Dellu-Hagedorn F. (2012) The synergy of working memory and inhibitory control: behavioral, pharmacological and neural functional evidences. Neurobiol. Learn. Mem. 97: 202-212.
  • de Visser L., Homberg J.R., Mitsogiannis M., Zeeb F.D., Rivalan M., Fitoussi A., Galhardo V., van den Bos R., Winstanley C.A. and Dellu-Hagedorn F. (2011) Rodent versions of the Iowa Gambling Task: opportunities and challenges for the understanding of decision-making, Front. Neurosci. 5:109.
  • Rivalan M, Coutureau E, Fitoussi A, Dellu-Hagedorn F (2011) Inter-individual decision-making differences in the effects of cingulate, orbitofrontal, and prelimbic cortex lesions in a rat gambling task. Front Behav Neurosci 5:22.
  • Rivalan M, Ahmed SH, Dellu-Hagedorn F. (2009) Risk-prone individuals prefer the worse options on a rat version of the Iowa Gambling Task. Biol. Psychiat., 66: 743-749.
  • Rivalan M, Blondeau C, Dellu-Hagedorn F (2009) Modeling symptoms of mental disorders using a dimensional approach in the rat. In: Endophenotypes of psychiatric and neurodegenerative disorders in rodent models (Granon S, ed). Kerala, India: Transworld Research Network.
  • Vancassel S, Blondeau C, Lallemand S., Cador M, Linard A., Lavialle M and Dellu-Hagedorn F. (2007) Hyperactivity in the rat is associated with spontaneous low level of n-3 polyunsaturated fatty acids in the frontal cortex. Behav. Brain Res. 180 : 119-126.
  • Rivalan M, Gregoire S, Dellu-Hagedorn F (2007) Reduction of impulsivity with amphetamine in an appetitive fixed consecutive number schedule with cue for optimal performance in rats. Psychopharmacology (Berl) 192:171-182.
  • Blondeau C. and Dellu-Hagedorn F. (2007) Dimensional analysis of ADHD subtypes in rats. Biol. Psychiat., 61: 1340-50.
  • Dellu-Hagedorn F (2006) Relationship between impulsivity, hyperactivity and working memory: a differential analysis in the rat. Behav Brain Funct 2:10.
  • Dellu-Hagedorn F (2005) Spontaneous individual differences in cognitive performances of young adult rats predict locomotor response to amphetamine. Neurobiol Learn Mem 83:43-47.
  • Dellu-Hagedorn F, Trunet S, Simon H (2004) Impulsivity in youth predicts early age-related cognitive deficits in rats. Neurobiol Aging 25:525-537.