Institut de Neurosciences Cognitives et Intégratives d'Aquitaine (UMR5287)

Aquitaine Institute for Cognitive and Integrative Neuroscience

Université de Bordeaux

Zone nord Bat 2 2ème étage
146, rue Léo Saignat
33076 Bordeaux cedex


Supervisory authorities

CNRS Ecole Pratique des Hautes Etudes Université de Bordeaux

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Neurocampus Unitéde Formation de Biologie


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Cador Martine

by Catherine Le Moine - published on , updated on

Martine Cador

Statut - Organisme de rattachement Fonction

Director of Research 1st class CNRS

+33 (0)5 57 57 15 46

Site : Charles Perrens

Neuropsychopharmacology of addiction

Behavioral and neurobiological substrates of drug taking and drug seeking using rodent behavioral models

Research axis:

  • Behavioral mechanisms of the relapse process: automatisms , motivation, memories?
  • Role of a temporal window in the vulnerability to develop reward seeking: adolescence vs adulthood
  • Comparisons between natural and pharmacological rewards
  • Involvement of the dopaminergic systems and associated structures in drug taking behavior
  • Development of new therapeutic tools

Scientific expertise:

  • Animal behavior in general
  • Animal models of addiction
  • Opiate, cocaine and nicotine dependence
  • Neurobiology the mesocorticolimbic dopaminergic system, including nucleus accumbens, amygdale, prefrontal cortex
  • Transitory inactivation or lesion of cerebral structures
  • Systemic or intra cerebral pharmacology


  • 1. Behavioral automatism and drug addiction
  • 2. Adolescent exposure to sweet and addictive behavior later on in adulthood
  • 3. STN implication in heroin and nicotine taking behavior (Collaboration Christelle Baunez (Marseille).
  • 4. Aversive memories associated with opiate withdrawal and drug seeking (Collaboration with Catherine Le Moine, Thomas Boraud and Martine Cador)
  • 5. Decision-making and vulnerability to nicotine or cocaine addiction (Collaboration with Françoise Dellu-Hagedorn et Martine Cador)

Selected Publications:

  • Stinus L., Cador M., Zorrilla E.P., Koob G.F. Buprenorphine and a CRF1 antagonist block the acquisition of opiate withdrawal-induced conditioned place aversion in rats. Neuropsychopharmacology (2005) 30(1): 90-98
  • Frenois F., Stinus L., Di Blasi C., Cador M., Le Moine C. A specific limbic circuit underlies opiate withdrawal memories. Journal of Neuroscience (2005) 9; 25(6): 1366-1374
  • Baunez C., Dias C., Cador M., Amalric M. The subthalamic nucleus exerts opposite control on cocaine and ’natural’ rewards. Nature Neuroscience (2005) 8(4): 484-489
  • Barbano M.F., Cador M. Various aspects of feeding behavior can be partially dissociated in the rat by the incentive properties of food and the physiological state. Behavioral Neuroscience (2005) 119: 1244-1253
  • Guillem K., Vouillac C., Azar M.R., Parsons L.H., Koob G.F., Cador M., Stinus L. Monoamine oxidase inhibition dramatically increases the motivation to self-administer nicotine in rats. Journal of Neuroscience (2005) 38: 8593-8600
  • Ahmed S.H., Cador M. Dissociation of psychomotor sensitization from compulsive cocaine consumption. Neuropsychopharmacology (2006) 31: 563-571
  • Barbano M.F., Cador M. Differential regulation of the consummatory, motivational and anticipatory aspects of feeding behavior by dopaminergic and opioidergic drugs, Neuropsychopharmacology (2006) 31: 1371-81
  • Guillem K., Vouillac C., Azar M.R., Parsons L.H., Koob G.F., Cador M., Stinus L. Monoamine oxidase A rather than monoamine oxidase B inhibition increases nicotine reinforcement in rats. European Journal of Neuroscience (2006) 24: 3532-40.
  • Pacchioni A.M., Cador M., Bregonzio C., Cancela L.M. A Glutamate-Dopamine Interaction in the Persistent Enhanced Response to Amphetamine in Nucleus Accumbens Core but not Shell Following a Single Restraint Stress. Neuropsychopharmacology (2007) 32: 682-692
  • Barbano M.F., Cador M. Opioids for hedonic experience and dopamine to get ready for it. Psychopharmacology (2007) 191(3): 497-506
  • Zittel-Lazarini A., Cador M., Ahmed S. H. A critical transition in cocaine self-administration: behavioral and neurobiological implications. Psychopharmacology, (2007) 192(3): 337
  • Guillem K., Vouillac C., Koob G.F., Cador M., Stinus L. Monoamine oxidase inhibition dramatically prolongs the aversive motivational state associated with nicotine withdrawal. Biological Psychiatry (2008) 63(2): 158-163
  • Keiflin R., Vouillac C., Cador M. Level of operant training rather than cocaine intake predicts level of reinstatement. Psychopharmacology (2008) 197(2): 247-261
  • Keiflin R., Isingrini E., Cador M. Cocaine-induced reinstatement in rats: evidence for a critical role of cocaine stimulus properties. Psychopharmacology (2008) 197(4): 649-660
  • Lucas M., Frenois F., Le Roy C., Georges F., Vouillac C., Stinus L., Cador M., Le Moine C. Immediate early gene expression reveals neuronal plasticity in different amygdala nuclei during opiate withdrawal memory formation. Neuroscience (2008) 154: 1021-1033
  • Berthet A., Porras G., Doudnikoff E., Stark H., Cador M., Bezard E., Bloch B. Pharmacological analysis demonstrates dramatic alteration of D1 dopamine receptor neuronal distribution in the rat analog of L-DOPA-induced dyskinesia. Journal of Neuroscience (2009) 29(15): 4829-4835
  • Clemens K., Caille-Garnier S., Stinus L., Cador M. The addition of five minor tobacco alkaloids increases nicotine-induced hyperactivity, sensitization and intravenous self-administration in rats. International Journal of Neuropsychopharmacology (2009) 15: 1-12
  • Barbano M.F., Le Saux M., Cador M. Involvement of dopamine and opioids in the motivation to eat: influence of palatability, homeostatic state and behavioral paradigms. Psychopharmacology (2009) 203(3): 475-487
  • Caillé S., Guillem K., Cador M., Manzoni O., Georges F. Voluntary nicotine consumption triggers in vivo potentiation of cortical excitatory drives to midbrain dopaminergic neurons. Journal of Neuroscience (2009) 29(33): 10410-10415
  • Rouaud T., Lardeux S., Payanotis N., Parelessompoulle D., Cador M., Baunez C. Reducing the desire for cocaine: subthalamic nucleus deep brain stimulation reduces motivation for cocaine. Proceedings National Academy of Science (2010) 107, 3, 1196-1200.
  • Richard E, Helbling J-C, Tridon C, Desmedt A., Minni A.M., Cador M, Pourtau L., Konsman J-P, Mormède P., Moisan M.-P. Plasma transcortin influences endocrine and behavioural stress responses in mice. Endocrinology (2010) 151,: 649-659
  • Vendruscolo L, Gueye A, Darnaudery M, Ahmed S, Cador M, Sugar Overconsumption during Adolescence Selectively Alters Motivation and Reward Function in Adult Rats, Plos One (2010), 5, e9296
  • Clemens K, Caille S, Cador M, The effect of operandum and food-training on nicotine intravenous self-administration and reinstatement, Psychopharmacology, (2010) Jul;211(1):43-54
  • Vendruscolo L, Gueye AB, Vendruscolo JCM, Clemens KJ Mormède P, Darnaudery M, Cador M, Reduced alcohol drinking in adult rats exposed to sucrose during adolescence, Neuropharmacology, (2010), 59(6):388-94
  • Caille S, Clemens K, Stinus L & Cador M Modeling nicotine addiction in rats. Methods in molecular biology (Clifton, N.J.) (2012) 829, 243-56.
  • Lucas M, Frenois F, Cador M. Le Moine C. Remodeling of the neuronal circuits underlying opiate-withdrawal memories following remote retrieval. Neurobiology of learning and memory (2012) 97, 47-53.
  • Baldo BA, Pratt WE, Will MJ, Hanlon EC, Bakshi VP & Cador M (2013) Principles of motivation revealed by the diverse functions of neuropharmacological and neuroanatomical substrates underlying feeding behavior. Neuroscience and Biobehavioral Reviews 37, 1985-1998.
  • Reisiger AR, Kaufling J, Manzoni O, Cador M, Georges F & Caille S (2014) Nicotine self-administration induces CB1-dependent LTP in the bed nucleus of the stria terminalis. J Neurosci 34, 4285-92.
  • Fitoussi A, Le Moine C, De Deurwaerdère P, Matéo Laqui, Rivalan M, Cador M, Dellu-Hagedorn F (2015) Prefronto-subcortical imbalance characterizes poor decision-making: neurchemical and neural functional evidences in rats. Brain Struct Funct 220: 1863-2653
  • Hachem-Delaunay S, Fournier ML, Cohen C, Bonneau N, Cador M, Baunez C, Le Moine C (2015) Subthalamic nucleus high-frequency stimulation modulates neuronal reactivity to cocaine within the reward circuit. Neurobiol Dis 80:54-62
  • Naneix F, Darlot F, Coutureau E, Cador M (2016) Long-lasting deficits in hedonic and nucleus accumbens reactivity to sweet rewards by sugar overconsumption during adolescence. European Journal of Neuroscience, 43, 671–680.
  • Romani Perez M, Lépinay M, Alonso L, Rincel M, Xia L, Fanet H, Caillé S, Cador M, Laye S, Vancassel S, Darnaudery M (2016) Impact of a maternal high fat diet and maternal separation on energy homeostasis and food-motivated behavior, Int J Obesity 41 : 502-509.
  • Simonnet A, Zamberletti E, Cador M, Rubino T, Caillé S (2017) Chronic FAAH inhibition during nicotine abstinence alters habenular CB1 receptor activity and precipitates depressive-like behaviors, Neuropharmacology. 113:252-259.
  • Dejean C, Sitko M, Girardeau P, Bennabi A, Caillé S, Cador M, Boraud T, Le Moine C (2017) Memories of opiate withdrawal emotional states correlate with specific gamma oscillations in the nucleus accumbens. Neuropsychopharmacology 42:1157-1168.
  • Fitoussi A, Renault P, Le Moine C, Coutureau E, Cador M, Dellu-Hagedorn F (2018) Inter-individual differences in decision-making, flexible and goal-directed behaviors: novel insights within the prefronto-striatal networks. Brain Structure & Function. 223:897-912.
  • Naneix F., Darlot F., De Smedt-Peyrusse V., Pape J.R., Coutureau E., Cador M. (2018) Protracted motivational dopamine-related deficits following adolescence sugar overconsumption. Neuropharmacology. doi: 10.1016/j.neuropharm.2017.11.021.
  • Gueye A.B., Vendruscolo L.F., de Ávila C., Le Moine C., Darnaudéry M., Cador M. (2018) Unlimited sucrose consumption during adolescence generates a depressive-like phenotype in adulthood. Neuropsychopharmacology. doi: 10.1038/s41386-018-0025-9.


  • ANR STNMotiv (2009-2013) Role of the subthalamique nucleus (STN) in drug addiction : du rat au patient parkinsonien . (Collaboration Christelle Baunez, Marseille, Catherine Le Moine, Addicteam INCIA, Bordeaux)
  • MIlLDT/IREB 2009-2011. Effets sur les rongeurs de l’exposition pendant l’adolescence à des solutions sucrées et alcoolisées(« premix ») sur la consommation à l’âge adulte d’alcool et de sucre .
  • ANR Programme Blanc Memopiate (2009-2013), (Collaboration C Le Moine, S Caillé-Garnier, (INCIA) T Boraud (IMN) Bordeaux, M Cador).
  • Fonds Français Alimentation Santé (2013-2015): "Un modèle neurodéveloppemental du plaisir alimentaire: l’exposition à des aliments sucrés à l’adolescence et ses conséquences." PI M. Cador,in collaboration with E. Coutureau’s team (DECAD, INCIA)