Institut de Neurosciences Cognitives et Intégratives d'Aquitaine (UMR5287)

Aquitaine Institute for Cognitive and Integrative Neuroscience



INCIA - UMR 5287- CNRS
Université de Bordeaux

Zone nord Bat 2 2ème étage
146, rue Léo Saignat
33076 Bordeaux cedex
France

Téléphone 05.57.57.15.51
Télécopie 05.56.90.14.21

Supervisory authorities

CNRS Ecole Pratique des Hautes Etudes Université de Bordeaux

Our partners

Neurocampus Unitéde Formation de Biologie

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Contarino Angelo

by Catherine Le Moine - published on , updated on

MCU University Bordeaux 2

Contact: e-mail
+33 (0)5 57 57 12 21

Site : Carreire

Team:
Search for targets to regulate the systems of stress

Domain:
Neuroscience, drug addiction, stress, emotion, cognition

Research axis:
opiate and psychostimulant addiction

Scientific expertise:
role of stress systems in drug addiction

Projects:

1) Role of the CRF system in opiate addiction
2) Psychostimulant drug abuse, drug dependence and stress: their relationship to psychotic states with a focus on the corticotropin-releasing factor system

Selected Publications:

Morisot N, Rouibi K & Contarino A CRF2 receptor-deficiency eliminates the long-lasting vulnerability of motivational states induced by opiate withdrawal Neuropsychopharmacology (in press).

Morisot N, Millan MJ, ContarinoA. CRF1 receptor-deficiency induces anxiety-like vulnerability to cocaine. Psychopharmacology (Berl). 2014 Oct;231(20):3965-72.

Morisot N, Le Moine C, Millan MJ & Contarino A (2014) CRF2 receptor-deficiency reduces recognition memory deficits and vulnerability to stress induced by cocaine withdrawal. Int J Neuropsychopharmacol 1-11.

Rouibi K, Contarino A. The corticotropin-releasing factor receptor-2 mediates the motivational effect of opiate withdrawal. Neuropharmacology. 2013 Oct;73:41-7.

Ingallinesi M, Rouibi K, Le Moine C, Papaleo F & Contarino A (2012) CRF2 receptor-deficiency eliminates opiate withdrawal distress without impairing stress coping. Molecular Psychiatry 17, 1283-1294.

Papaleo F, Ghozland S, Ingallinesi M, Roberts AJ, Koob GF, Contarino A. Disruption of the CRF(2) receptor pathway decreases the somatic expression of opiate withdrawal. Neuropsychopharmacology. 2008 Nov;33(12):2878-87.

Papaleo F, Kitchener P, Contarino A.
Disruption of the CRF/CRF1 receptor stress system exacerbates the somatic signs of opiate withdrawal. Neuron. 2007 Feb 15;53(4):577-89.

Contarino A, Papaleo F.
The corticotropin-releasing factor receptor-1 pathway mediates the negative affective states of opiate withdrawal. Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18649-54.

Grants: : Institut de Recherche Servier (collaboration with Dr. M. Millan).