MCU University Bordeaux 2
Contact: e-mail
+33 (0)5 57 57 12 21
Site : Carreire
Team:
Search for targets to regulate the systems of stress
Domain:
Neuroscience, drug addiction, stress, emotion, cognition
Research axis:
opiate and psychostimulant addiction
Scientific expertise:
role of stress systems in drug addiction
Projects:
1) Role of the CRF system in opiate addiction
2) Psychostimulant drug abuse, drug dependence and stress: their relationship to psychotic states with a focus on the corticotropin-releasing factor system
Selected Publications:
Morisot N, Rouibi K & Contarino A CRF2 receptor-deficiency eliminates the long-lasting vulnerability of motivational states induced by opiate withdrawal Neuropsychopharmacology (in press).
Morisot N, Millan MJ, ContarinoA. CRF1 receptor-deficiency induces anxiety-like vulnerability to cocaine. Psychopharmacology (Berl). 2014 Oct;231(20):3965-72.
Morisot N, Le Moine C, Millan MJ & Contarino A (2014) CRF2 receptor-deficiency reduces recognition memory deficits and vulnerability to stress induced by cocaine withdrawal. Int J Neuropsychopharmacol 1-11.
Rouibi K, Contarino A. The corticotropin-releasing factor receptor-2 mediates the motivational effect of opiate withdrawal. Neuropharmacology. 2013 Oct;73:41-7.
Ingallinesi M, Rouibi K, Le Moine C, Papaleo F & Contarino A (2012) CRF2 receptor-deficiency eliminates opiate withdrawal distress without impairing stress coping. Molecular Psychiatry 17, 1283-1294.
Papaleo F, Ghozland S, Ingallinesi M, Roberts AJ, Koob GF, Contarino A. Disruption of the CRF(2) receptor pathway decreases the somatic expression of opiate withdrawal. Neuropsychopharmacology. 2008 Nov;33(12):2878-87.
Papaleo F, Kitchener P, Contarino A.
Disruption of the CRF/CRF1 receptor stress system exacerbates the somatic signs of opiate withdrawal. Neuron. 2007 Feb 15;53(4):577-89.
Contarino A, Papaleo F.
The corticotropin-releasing factor receptor-1 pathway mediates the negative affective states of opiate withdrawal. Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18649-54.
Grants: : Institut de Recherche Servier (collaboration with Dr. M. Millan).