Institut de Neurosciences Cognitives et Intégratives d'Aquitaine (UMR5287)

Aquitaine Institute for Cognitive and Integrative Neuroscience

Université de Bordeaux

Zone nord Bat 2 2ème étage
146, rue Léo Saignat
33076 Bordeaux cedex


Supervisory authorities

CNRS Ecole Pratique des Hautes Etudes Université de Bordeaux

Our partners

Neurocampus Unitéde Formation de Biologie


GDR Robotique GDR Mémoire GDR Multi-électrodes


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Catheline Gwenaëlle

by Joel Swendsen - published on , updated on

Assistant Professor (Maître de Conférences) - EPHE

+33 (0)5 57 57 17 33

Site : Carreire

Neuroimaging and Human Cognition

Normal and Pathological Cerebral Ageing

Areas of research:

  • Functional and Anatomical Brain networks
  • Age-related cognitive decline
  • Neurodegenerative Disease (Alzheimer’s Disease)

Scientific expertise:

  • Neuroimaging
  • Morphological MRI (3D, DTI)
  • Neuroanatomy


  • A core objective of our research was therefore to examine how anatomo-functional deficits can be related to cognitive behavioral impairment in age-related neurodegenerative diseases. With this aim, we have applied advanced neuroimaging techniques in order to understand the etiology and pathophysiology of CNS disorders as well as the conditions associated with their expression. Concerning imagery techniques, we have implemented the multimodal imaging approach coupling morphological and functional MRI techniques for large cohorts with several hundred of subjects. Actually two cohorts of elderly are in process: 1- a population-based sample screened prospectively the emergence of imaging abnormalities and cognitive-behavioral impairments (330 subjects), as part of the 3City cohort (Montpellier, Bordeaux, Dijon);2- a population-based sample living in the rural community of Gironde (300 subjects from AMImage study).

Selected Publications:

  • Baillet M., Cosin C., Schweitzer P., Pérès K., Catheline G., Swendsen J., Mayo W. , Mood Influences the Concordance of Subjective and Objective Measures of Sleep Duration in Older Adults. Front Aging Neurosci. 2016 Jul 26;8:181. doi: 10.3389/fnagi.2016.00181
  • Pelletier, A., Periot, O., Dilharreguy, B., Hiba, B., Bordessoules, M., Chanraud, S., Pérès, K., Amieva, H., Dartigues, J.-F., Allard, M., Catheline, G., 2016. Age-Related Modifications of Diffusion Tensor Imaging Parameters and White Matter Hyperintensities as Inter-Dependent Processes. Frontiers in Aging Neuroscience 7. 2016 Jan 19;7:255. doi: 10.3389/fnagi.2015.00255.
  • Bernard, C., Catheline, G., Dilharreguy, B., Couffinhal, T., Ledure, S., Lassalle-Lagadec, S., Callaert, D., Allard, M., Sibon, I., 2015. Cerebral changes and cognitive impairment after an ischemic heart disease: a multimodal MRI study. Brain Imaging Behav. doi:10.1007/s11682-015-9483-4
  • Coupé, P., Fonov, V.S., Bernard, C., Zandifar, A., Eskildsen, S.F., Helmer, C., Manjón, J.V., Amieva, H., Dartigues, J.-F., Allard, M., Catheline, G., Collins, D.L., The Alzheimer’s Disease Neuroimaging Initiative, 2015. Detection of Alzheimer’s disease signature in MR images seven years before conversion to dementia: Toward an early individual prognosis: Preclinical AD Detection Using Hippocampal Grading. Human Brain Mapping n/a–n/a. doi:10.1002/hbm.22926
  • Bernard, C., Dilharreguy, B., Helmer, C., Chanraud, S., Amieva, H., Dartigues, J.-F., Allard, M., Catheline, G., 2015b. PCC characteristics at rest in 10-year memory decliners. Neurobiology of Aging 36, 2812–2820. doi:10.1016/j.neurobiolaging.2015.07.002
  • Pelletier, A., Barul, C., Féart, C., Helmer, C., Bernard, C., Periot, O., Dilharreguy, B., Dartigues, J.-F., Allard, M., Barberger-Gateau, P., Catheline, G., Samieri, C., 2015. Mediterranean diet and preserved brain structural connectivity in older subjects. Alzheimer’s & Dementia 11, 1023–1031. doi:10.1016/j.jalz.2015.06.1888
  • Ben Ahmed, O., Mizotin, M., Benois-Pineau, J., Allard, M., Catheline, G., Ben Amar, C., 2015. Alzheimer’s disease diagnosis on structural MR images using circular harmonic functions descriptors on hippocampus and posterior cingulate cortex. Computerized Medical Imaging and Graphics 44, 13–25. doi:10.1016/j.compmedimag.2015.04.007
  • Potvin, O., Catheline, G., Bernard, C., Meillon, C., Bergua, V., Allard, M., Dartigues, J.-F., Chauveau, N., Celsis, P., Amieva, H., 2015. Gray matter characteristics associated with trait anxiety in older adults are moderated by depression. International Psychogeriatrics 27, 1813–1824. doi:10.1017/S1041610215000836
  • Catheline, G., Amieva, H., Dilharreguy, B., Bernard, C., Duperron, M.-G., Helmer, C., Dartigues, J.-F., Allard, M., 2015. Semantic retrieval over time in the aging brain: Structural evidence of hippocampal contribution. Hippocampus. 2015 Sep;25(9):1008-16. doi: 10.1002/hipo.22423.
  • Ben Ahmed, O., Benois-Pineau, J., Ben Amar, C., Allard, M., Catheline, G., 2013. Early Alzheimer Disease Detection With Bag-Of-Visual-Words And Hybrid Fusion On Structural MRI, in: Czuni, L and Schoffmann, K and Sziranyi, T (Ed.), 2013 11TH INTERNATIONAL WORKSHOP ON CONTENT-BASED MULTIMEDIA INDEXING (CBMI 2013), International Workshop on Content-Based Multimedia Indexing. IEEE, 345 E 47TH ST, NEW YORK, NY 10017 USA, pp. 79–83.
  • Allard, M., Husky, M., Catheline, G., Pelletier, A., Dilharreguy, B., Amieva, H., … Swendsen, J. (2014). Mobile Technologies in the Early Detection of Cognitive Decline. PLoS ONE, 9(12), e112197. doi:10.1371/journal.pone.0112197
  • Bernard C, Helmer C, Dilharreguy B, Amieva H, Auriacombe S, Dartigues JF, Allard M, Catheline G. Time course of brain volume changes in the preclinical phase of Alzheimer’s disease. Alzheimer’s § Dementia. 2014 Mar;10(2):143-151.e1. doi: 10.1016/j.jalz.2013.08.279.
  • Pelletier A, Periot O, Dilharreguy B, Hiba B, Bordessoules M, Pérès K, Amieva, H, Dartigues JF, Allard M, Catheline G. Structural hippocampal network alterations during healthy aging: a multi-modal MRI study. Front Aging Neurosci. 2013 Dec 5;5:84.
  • Bernard C, Dilharreguy B, Allard M, Amieva H, Bonnet F, Dauchy F, Greib C, Dehail P, Catheline G for the ANRS CO3 Aquitaine cohort study group coordinated by François Dabis. Muscular Weakness in Individuals with HIV Associated with a Disorganization of the Cortico-Spinal Tract: A Multi-Modal MRI Investigation. PlosOne 2013 Jul 11;8(7).
  • Lassalle-Lagadec S, Catheline G, Mayo W, Dilharreguy B, Renou P, Fleury O, Allard, M, Swendsen J, Sibon I. Cerebellum involvement in post-stroke mood: A combined ecological and MRI study. Psychiatry Res. 2013 May 30;212(2):158-60.
  • Mizotin, M., Benois-Pineau, J., Allard, M., Catheline, G., 2012. FEATURE-BASED BRAIN MRI RETRIEVAL FOR ALZHEIMER DISEASE DIAGNOSIS, in: 2012 IEEE INTERNATIONAL CONFERENCE ON IMAGE PROCESSING (ICIP 2012), IEEE International Conference on Image Processing ICIP. IEEE, 345 E 47TH ST, NEW YORK, NY 10017 USA, pp. 1241–1244.
  • Bonnet F, Amieva H, Marquant F, Bernard C, Bruyand M, Dauchy FA, Mercié P, Greib C, Richert L, Neau D, Catheline G, Dehail P, Dabis F, Morlat P, Dartigues, JF, Chêne G; for the Groupe d’Epidémiologie Clinique du SIDA en Aquitaine (GECSA). Cognitive disorders in HIV-infected patients: are they HIV-related? ANRS CO3 Aquitaine Cohort, Bordeaux, France, 2007-2009. AIDS. 2012 Oct 17. [Epub ahead of print] PubMed PMID: 23079813.
  • Foubert-Samier A, Catheline G, Amieva H, Dilharreguy B, Helmer C, Allard M, Dartigues JF. Education, occupation, leisure activities, and brain reserve: a population-based study. Neurobiol Aging. 2012 Feb;33(2):423.e15-25. Epub 2010 Nov12. PubMed PMID: 21074901.
  • Catheline G, Periot O, Amirault M, Braun M, Dartigues JF, Auriacombe S, Allard, M. Distinctive alterations of the cingulum bundle during aging and Alzheimer’s disease. Neurobiol Aging. 2010 Sep;31(9):1582-92. Epub 2008 Oct 1. PubMed PMID:18829135.