Assistant Professor (Maître de Conférences) - EPHE
Contact: gwenaelle.catheline@u-bordeaux.fr
+33 (0)5 57 57 17 33
Site : Carreire
Team:
Neuroimaging and Human Cognition
Domain:
Normal and Pathological Cerebral Ageing
Areas of research:
- Functional and Anatomical Brain networks
- Age-related cognitive decline
- Neurodegenerative Disease (Alzheimer’s Disease)
Scientific expertise:
- Neuroimaging
- Morphological MRI (3D, DTI)
- Neuroanatomy
Projects:
- A core objective of our research was therefore to examine how anatomo-functional deficits can be related to cognitive behavioral impairment in age-related neurodegenerative diseases. With this aim, we have applied advanced neuroimaging techniques in order to understand the etiology and pathophysiology of CNS disorders as well as the conditions associated with their expression. Concerning imagery techniques, we have implemented the multimodal imaging approach coupling morphological and functional MRI techniques for large cohorts with several hundred of subjects. Actually two cohorts of elderly are in process: 1- a population-based sample screened prospectively the emergence of imaging abnormalities and cognitive-behavioral impairments (330 subjects), as part of the 3City cohort (Montpellier, Bordeaux, Dijon);2- a population-based sample living in the rural community of Gironde (300 subjects from AMImage study).
Selected Publications:
- Coupé P, Manjón JV, Lanuza E, Catheline G. Lifespan Changes of the Human Brain In Alzheimer’s Disease. Sci Rep. 2019 Mar 8;9(1):3998.
- Baillet M., Dilharreguy B., Pérès K., Dartigues J.-F., Mayo W., Catheline G. Activity/rest cycle and disturbances of structural backbone of cerebral networks in aging. Neuroimage. 2016 Sep 21. pii: S1053-8119(16)30526-2. doi:10.1016
- Bernard, C., Dilharreguy, B., Helmer, C., Chanraud, S., Amieva, H., Dartigues, J.-F., Allard, M., Catheline G., 2015b. PCC characteristics at rest in 10-year memory decliners. Neurobiology of Aging 36, 2812–2820. doi:10.1016/j.neurobiolaging.2015.07.002
- Catheline G., Amieva, H., Dilharreguy, B., Bernard, C., Duperron, M.-G., Helmer, C., Dartigues, J.-F., Allard, M., 2015. Semantic retrieval over time in the aging brain: Structural evidence of hippocampal contribution. Hippocampus. 2015 Sep;25(9):1008-16. doi: 10.1002/hipo.22423.
- Bernard C, Helmer C, Dilharreguy B, Amieva H, Auriacombe S, Dartigues JF, Allard M, Catheline G. Time course of brain volume changes in the preclinical phase of Alzheimer’s disease. Alzheimer’s § Dementia. 2014 Mar;10(2):143-151.e1. doi: 10.1016/j.jalz.2013.08.279.