MCU - Université de Bordeaux 1
Contact:
[yoon.cho@u-bordeaux.fr]
+33 (0)5 40 00 87 46
Site : Talence
Team:
Neurobiology of Behavior
Domain: 
Cognitive and behavioural neuroscience Behavioral neurophysiology
Research axis:
Neurophysiopathology of Huntington’s disease Hippocampal information coding of episodic memory Hippocampal information coding of social cognition Development of new therapeutic interventions against neurodegenerative diseases
Scientific expertise: Cognitive behaviors In vivo electrophysiology Behavioural pharmacology Mouse models of neurodegenerative diseases
Projects:
Basal ganglia network dysfunction in Huntington’s disease Hippocampal codes for social cognition and their alteration in autism spectrum disorder Episodic information coding by the mouse hippocampus
Therapeutic interventions against Alzheimer’s and Huntington’s diseases
Collaborations: Bernadette Allinquant, INSERM, Paris Bruno Bontempi & Olivier Nicole, Institut des Maladies Neurodégénératives, Bordeaux Jean-René Cazalets, INCIA, Bordeaux Daniel Choquet, Interdisciplinary Institute for Neuroscience, Bordeaux Manuel Guzmán, Complutense University, Madrid, Spain Inah Lee, Seoul National University, South Korea Nicolas Mallet, Institut des Maladies Neurodégénératives, Bordeaux Aline Marighetto, Neurocentre Magendie, Bordeaux Nicole Mons, INCIA, Bordeaux Christophe Mulle, Interdisciplinary Institute for Neuroscience, Bordeaux Nathalie Sans, Neurocentre Magendie, Bordeaux Christina Unger, Karolinska Institute, Sweden
Selected Publications: Cayzac S, Ginguay A, Mons N, Allinquant B, Jeantet Y, Cho YH (2015) Altered hippocampal information coding and network synchrony in APP-PS1 mice, Neurobiology of Aging, Sep 1. pii: S0197-4580(15)00440-6.. Ragot A, Pietropaolo S, Vincent J, Delage P, Zhang H, Allainquant B, Leinkugel X, Fischer A, Cho YH (2015) Inhibition of the Histone Deacetylase 6 exacerbates selected behavioral deficits in the R6/1 mouse model for huntington’s disease, Brain and Behavior, 2015; 0(0), e00361. Lebreton F, Cayzac S, Pietropaolo S, Jeantet Y, Cho YH (2015) Sleep physiology alterations precede plethoric phenotypic changes in R6/1 Huntington’s disease mice, PlosOne, 10:e0126972. Pietropaolo S, Bellocchio L, Ruiz-Calvo A, Cabanas M, Du Z, Guzman M, Garret M & Cho Y (2014) Chronic cannabinoid receptor stimulation selectively prevents motor impairments in a mouse model of Huntington’s disease. Neuropharmacology, 89:368-74. Jeantet Y, Cayzac S & Cho YH (2013) beta oscillation during slow wave sleep and rapid eye movement sleep in the electroencephalogram of a transgenic mouse model of Huntington’s disease. PLoS ONE 8, e79509.
Jeantet Y & Cho YH (2012) Evolution of hippocampal spatial representation over time in mice. Neurobiology of Learning and Memory 98, 354-60. Lagadec S, Rotureau L, Hemar A, Macrez N, Delcasso S, Jeantet Y & Cho YH (2012) Early temporal short-term memory deficits in double transgenic APP/PS1 mice. Neurobiology of Aging 33, 203 e1-11. Pietropaolo S, Delage P, Lebreton F, Crusio WE & Cho YH (2012) Early development of social deficits in APP and APP-PS1 mice. Neurobiology of Aging 33, 1002 e17-27. Cayzac S, Delcasso S, Paz V, Jeantet Y & Cho YH (2011) Changes in striatal procedural memory coding correlate with learning deficits in a mouse model of Huntington disease. Proceedings of the National Academy of Sciences of the USA 108, 9280-5. Pietropaolo S, Delage P, Cayzac S, Crusio WE & Cho YH (2011) Sex-dependent changes in social behaviors in motor pre-symptomatic R6/1 mice. PLoS ONE 6, e19965. Cho YH & Jeantet Y (2010) Differential involvement of prefrontal cortex, striatum, and hippocampus in DRL performance in mice. Neurobiology of Learning and Memory 93, 85-91. Sachidhanandam S, Blanchet C, Jeantet Y, Cho YH & Mulle C (2009) Kainate receptors act as conditional amplifiers of spike transmission at hippocampal mossy fiber synapses. Journal of Neuroscience 29, 5000-8.
Grants:
2014-2018 ANR Générique « Hippencode », collaboration: Christophe Mulle, IINS 2014-2017 ANR Samenta « SynchrAutism », collaboration: Nathalie Sans, Neurocentre Magendie 2013-2015 Ligue Européen contre la maladie d’Alzheimer, collaboration: Bernadette Allainquant, INSERM, Paris 2009-2012 ANR « MemcodeADMice », collaboration; Agnes Hémar, IINS 2009-2010 BQR University of Bordeaux1