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Crusio Wim

DR1 - CNRS Directeur adjoint

Contact: wim.crusio@u-bordeaux1.fr +33 (0)5 40 00 89 00

Team: Neurogenetics of Cognitive Abilities

Domain: Behavioral and neural genetics of mouse behavior

Research axis:

  • Localization of genes involved in individual differences in hippocampal neuroanatomy and spatial learning
  • Autistic features in Fmr1 mice

Scientific expertise:

  • Mouse behavior
  • Mouse models of neurobehavioral disorders
  • Behavior genetics
  • Quantitative genetics

Projects:

  • Localization of genes involved in individual differences in hippocampal neuroanatomy and spatial learning
  • Autistic features in Fmr1 mice

Collaborations:

  • Robert Williams (University of Tennessee, Memphis, TN, USA)
  • Francesca D’Amato (National Research Council, Rome, Italy)
  • Peter McCaffery (University of Aberdeen, United-Kingdom)
  • Yann Mineur (Yale University, New Haven, CT, USA)
  • Sylvain Briault (UMR6218 Immunologie et embryologie moléculaires, Université d’Orléans, France)
  • Giovanni Marsicano (Neurocentre Magendie, Université de Bordeaux 2, France)

Selected Publications:

  • W.E. Crusio, G. Genthner-Grimm, and H. Schwegler. A quantitative-genetic analysis of hippocampal variation in the mouse. Journal of Neurogenetics 3: 203-214, 1986; reprinted in Journal of Neurogenetics 21: 197-208, 2007
  • W.E. Crusio, H. Schwegler, and H.-P. Lipp. Radial-maze performance and structural variation of the hippocampus in mice: A correlation with mossy fibre distribution. Brain Research 425: 182-185, 1987.
  • W.E. Crusio, H. Schwegler, and J.H.F. van Abeelen. Behavioral responses to novelty and structural variation of the hippocampus in mice. II. Multivariate genetic analysis. Behavioural Brain Research 32: 81-88, 1989.

Grants:

  • 2005-2011: Autistic-like behaviors in Fmr1 knockout mice. 12-FY05-1198, March of Dimes, White Plains, NY, USA (PI).
  • 2005-2012: Genetic regulation of hippocampal anatomy and learning. 1 R01 MH072920-01, National Institute of Mental Health, Bethesda, MD, USA (PI).
  • 2007-2012: IBANGS Annual Meeting Support. 2 R13 AA014431-04, National Institute on Alcohol Abuse and Alcoholism (with additional support from NIMH and NICHD), National Institutes of Health, MD, USA (Co-Investigator, PI: John Crabbe, Portland, OR, USA).
  • 2009-2012: Neuroprotective effects of brain glycogen in hypoglycemia. 1R15DK078370-01A2, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, MD, USA (Consultant, PI: Bartholomew Pederson).
  • 2009-2012: SYSGENET - European systems genetics network for the study of complex genetic human diseases using mouse genetic reference populations COST-BM0901-131109-06351, European Science Foundation, Brussels, Belgium (Coordinator of Work Package 5: Training & Mobility).
  • 2010-2011: Ultrasonic communication in a mouse model of Fragile X Syndrome and autism. CNRS/CNR-23779, Centre Nationale de la Recherche Scientifique/Consiglio Nazionale delle Ricerche, Paris, France, and Rome, Italy (co-PI).

Publications 2006-2011:

  • Y.S. Mineur, L.X. Huynh, and W.E. Crusio. Social behavior deficits in the Fmr1 mutant mouse. Behavioural Brain Research 168: 172-175, 2006.
  • W.E. Crusio. Inheritance of behavioral and neuroanatomical phenotypical variance: Hybrid mice are not always more stable than inbreds. Behavior Genetics, 36: 723-731, 2006.
  • M. Bernardet and W.E. Crusio. Fmr1 KO mice as a possible model of autistic features. TheScientificWorldJOURNAL, 6: 1164-1176, 2006.
  • Y.S. Mineur, C. Belzung, and W.E. Crusio. Effects of unpredictable chronic mild stress on anxiety and depression-like behavior in mice. Behavioural Brain Research, 175: 43-50, 2006.
  • F.A. Schroeder, C.L. Lin, W.E. Crusio, and S. Akbarian. Antidepressant-like effects of the histone deacetylase inhibitor, sodium butyrate, in the mouse.
  • Y.S. Mineur, C.C.G. Marican, C. Larue-Achagiotis, F. Sluyter, and W.E. Crusio. Effects of chronic alcohol consumption on hippocampal anatomy and associated behaviors in three inbred strains of mice. Open Behavioral Science Journal, 1: 5-12, 2007.
  • Y.S. Mineur, C. Belzung, and W.E. Crusio. Functional implications of decreases in neurogenesis following chronic mild stress in mice. Neuroscience 150: 251-259, 2007.
  • P. Mormède, M.-P. Moissan, and W.E. Crusio. A polymorphic glucocorticoid receptor in a mouse population may or may not explain inherited altered stress response and increased anxiety-type behaviors. FASEB Journal, 22: 5-6, 2008.
  • A.-G. Calas, O. Richard, S. Même, J.-C. Beloeil, B.-T. Doan, T. Gefflaut, W. Même, W.E. Crusio, J. Pichon, and C. Montécot. Chronic exposure to glufosinate-ammonium induces spatial memory impairments, hippocampal MRI modifications and glutamine synthetase activation in mice. Neurotoxicology, 29: 740-747, 2008.
  • W.E. Crusio, D. Goldowitz, A. Holmes, and D. Wolfer. Standards for the publication of mouse mutant studies. Genes, Brain and Behavior 8: 1-4, 2009.
  • Y.S. Mineur and W.E. Crusio. Behavioral effects of ventilated micro-environment housing in three inbred mouse strains. Physiology and Behavior, 97: 334–340, 2009.
  • S. Pietropaolo and W.E. Crusio. Strain-dependent changes in acoustic startle response and its plasticity across adolescence in mice. Behavior Genetics, 39: 623-631, 2009.
  • K. Schughart, D. Arends, P. Andreux, R. Balling, A. Beyer, A. Bezerianos, G. Brockmann, W.E. Crusio, J. Campbell-Tofte, P. Denny, J.M. Falcon-Perez, J. Forejt, P. Franken, I. Hovatta, F. Iraqi, R.C. Jansen, L. Kaczmarek, M.J. Kas, K. Kashofer, E. Knapska, F. Kolisis, S. Kõks, S. Möller, X. Montagutelli, G. Morahan, R. Mott, S. Pfoertner, P. Prins, R. Przewlocki, A. Ranki, J. Santos, P. Rihet, L. Schalkwyk, A.B. Smit, M. Swertz, D. Threadgill, E. Vasar, and K. Zatloukal. SYSGENET – a meeting report from a new European network for systems genetics. Mammalian Genome, 21: 331-336, 2010.
  • S. Pietropaolo, A. Guilleminot, B. Martin, F. D’Amato, and W.E. Crusio. Genetic-background modulation of core and variable autistic-like symptoms in Fmr1 knock-out mice. PLoS ONE, 6: e17073, 2011.
  • S. Pietropaolo and W.E. Crusio. Genes and cognition. Wiley Interdisciplinary Reviews: Cognitive Science, 2: 345-352, 2011.
  • S. Pietropaolo, P. Delage, S. Cayzac, W.E. Crusio, and Y.H. Cho. Sex-dependent changes in social behaviors in motor pre-symptomatic R6/1 mice. PLoS ONE, 6: e19965, 2011.
  • W.E. Crusio, F. Sluyter, and R.T. Gerlai. Current status of the field. In: W.E. Crusio, S. Pietropaolo, F. Sluyter, and R.T. Gerlai (Eds.) Handbook of Behavioral Genetics of the Mouse. Vol. 1. Genetics of Behavioral Phenotypes. Cambridge University Press, Cambridge, United Kingdom, in press, 2011.
  • W.E. Crusio, F. Sluyter, and R.T. Gerlai. Ethogram of the mouse. In: W.E. Crusio, S. Pietropaolo, F. Sluyter, and R.T. Gerlai (Eds.) Handbook of Behavioral Genetics of the Mouse. Vol. 1. Genetics of Behavioral Phenotypes. Cambridge University Press, Cambridge, United Kingdom, in press, 2011.
  • W.E. Crusio. Learning and memory: radial maze. In: W.E. Crusio, S. Pietropaolo, F. Sluyter, and R.T. Gerlai (Eds.) Handbook of Behavioral Genetics of the Mouse. Vol. 1. Genetics of Behavioral Phenotypes. Cambridge University Press, Cambridge, United Kingdom, in press, 2011.
  • W.E. Crusio. Exploratory behavior. In: W.E. Crusio, S. Pietropaolo, F. Sluyter, and R.T. Gerlai (Eds.) Handbook of Behavioral Genetics of the Mouse. Vol. 1. Genetics of Behavioral Phenotypes. Cambridge University Press, Cambridge, United Kingdom, in press, 2011.
  • S. Pietropaolo and W.E. Crusio. Learning spatial orientation. In: N.M. Seel (Ed.) Encyclopedia of the Sciences of Learning, in press, 2012.
  • S. Pietropaolo, P. Delage, F. Lebreton, W.E. Crusio, and Y.H. Cho. Early development of social deficits in APP and APP-PS1 mice. Neurobiology of Aging, in press, 2012.