Institut de Neurosciences Cognitives et Intégratives d'Aquitaine (UMR5287)

Aquitaine Institute for Cognitive and Integrative Neuroscience

Université de Bordeaux

Zone nord Bat 2 2ème étage
146, rue Léo Saignat
33076 Bordeaux cedex


Supervisory authorities

CNRS Ecole Pratique des Hautes Etudes Université de Bordeaux

Our partners

Neurocampus Unitéde Formation de Biologie


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Pietropaolo Susanna

by Loïc Grattier - published on , updated on


ORCID number:

+33 (0)5 40 00 87 48

Site : Talence


Behavioral genetics of mouse models of neurodevelopmental and neuropsychiatric disorders

Research axis:

  • Genetic and neural bases of social behaviors: affiliation, aggression, communication, sexual behavior, mother-infant interactions
  • Gene-environment interactions in animal models of social disorders
  • Novel therapeutic targets for rare neurodevelopmental disorders

Scientific expertise:

  • Mouse behavior
  • Mouse models of neuropsychiatric disorders
  • The evaluation of social behavior in genetic mouse models of neurodevelopmental disorders


  • Autistic-like social and cognitive deficits in the Fmr1-KO mouse line: neurobiological and therapeutical applications
  • The role of the endocannabinoid system in the modulation of social behaviors
  • Social deficits as early markers of neuropathology in genetic mouse models of neurodegenerative disorders
  • Maternal enrichment as a treatment for the behavioral deficits of the Fmr1-KO mouse
  • The role of BKCa channels in Williams-Beuren syndrome
  • The relevance of the analysis of ultrasonic vocalizations in the validation of mouse models of neurodevelopmental disorders


  • Dr. Victoria Campuzano at the University Pompeu Faubra, Barcelona, Spain
  • Prof. Fernando Colmenares at the Department of Psychobiology, Complutense University of Madrid.
  • Dr. Francesca D’amato at the CNR of Rome.
  • Dr. Didier Dulon, CHU Pellegrin, Bordeaux and Institut pour l’audition, Paris, France.
  • Dr. Andreas Frick at the cortical plasticity laboratory, Neurocentre Magendie, Bordeaux, France.
  • Dr. Manuel Guzman at the Department of Biochemistry, Complutense University of Madrid.
  • Dr. Giovanni Marsicano at the INSERM U862, laboratoire de Physiopathologie de la plasticité neuronale, Bordeaux, France.
  • Prof. Maurizio Memo and Sara Bonini, University of Brescia, Italy.
  • Dr. Jose lopez-Moreno at the Department of Psychobiology, Complutense University of Madrid.
  • Dr. Giovanni Provenzano, CIBIO, Trento University, Italy
  • Dr. Michele Studer, University Cote d’Azur, Nice, France
  • Dr. M. Wohr, University of Marburg, Germany

Selected Publications 2016-2021:

  • Pietropaolo S., D’Amato F.R., Crusio W.E. Treatment approaches in rodent models for autism spectrum disorder. In: Social Behavior from Rodents to Humans: Neural Foundations and Clinical Implications, Wohr M. and Krach, S. Eds., Springer, Curr Top Behav Neurosci. 2016 Feb 9
  • Gauducheau M., Lemaire-Mayo V., D’amato F.R., Oddi D., Crusio W.E., Pietropaolo S. Age-specific autistic-like behaviors in heterozygous Fmr1-KO female mice. Autism Research, 2017 Jun;10(6):1067-1078. doi: 10.1002/aur.1743.
  • Gaudissard J., Ginger M., Premoli M., Memo M., Frick A.*, Pietropaolo S.* Behavioural abnormalities in the Fmr1-KO2 mouse model of Fragile X syndrome: the relevance of early life phases. Autism Research, 2017 Jun 7. doi: 10.1002/aur.18141.
  • Pietropaolo S., Crusio W.E., Feldon J. Gene-environment interactions in neurodevelopmental disorders. Neural plasticity, 2017 : 9272804.-
  • Carreno-Munoz M.I., Martins F., Medrano M.C., Aloisi E., Pietropaolo S., Dechaud C., Subashi E., Bony G., Ginger M., Moujahid A., Frick A., Leinekugel X. Potential Involvement of Impaired BKCa Channel Function in Sensory Defensiveness and Some Behavioral Disturbances Induced by Unfamiliar Environment in a Mouse Model of Fragile X Syndrome. Neuropsychopharmacology. 2017 Jul 19. doi: 10.1038/npp.2017.149.
  • Fyke W., Premoli M., Echeverry Alzate V., López-Moreno J.A., Lemaire-Mayo V., Crusio W.E., Marsicano G., Wöhr M., Pietropaolo S.. Communication and social interaction in the cannabinoid-type 1 receptor null mouse: Implications for autism spectrum disorder. Autism Res. 2021 Jun 26. doi: 10.1002/aur.2562.
  • Pietropaolo S., Marsicano G.The role of the endocannabinoid system as a therapeutic target for autism spectrum disorder: Lessons from behavioral studies on mouse models. Neurosci Biobehav Rev. 2021 Nov 20:S0149-7634(21)00525-X. doi: 10.1016/j.neubiorev.2021.11.031
  • Peineau T., Belleudy S., Pietropaolo S., Bouleau Y., Dulon D. Synaptic Release Potentiation at Aging Auditory Ribbon Synapses. Front Aging Neurosci. 2021 Oct 18;13:756449. doi: 10.3389/fnagi.2021.756449. eCollection 2021.
  • Pietropaolo S. Animals and biotechnologies: the impact of genetic engineering on human-animal relationships. In: Human/Animal Relationships in Transformation. Scientific, moral and legal perspectives (Vitale A., Pollo S., Eds), Palgrave MacMillan, 2021 (ISBN: 978-3-030-85276-4)

Publications 2010-2015:

  • Pietropaolo S., Crusio W.E. Genes and Cognition. 2010. Wiley Interdisciplinary Reviews: Cognitive Science (WIREs Cognitive Science). 2:345-352
  • Pietropaolo S., Guilleminot A., Martin B., D’Amato F., Crusio W.E. Genetic-background modulation of core and variable autistic-like symptoms in Fmr1 knock-out mice, PLoS One. 2011, 6(2), e17073
  • Pietropaolo S., Delage P., Cayzac S., Crusio W.E., Cho Y. H. Altered social and non-social behaviors in motor pre-symptomatic R6/1 mice: the importance of sex differences. PLoS One. 2011, 6(2), e17073
  • Pietropaolo S., Delage P., Lebreton F., Crusio W. E., Cho Y. H. Early development of social deficits in APP and APP-PS1 mice. Neurobiology of Aging, 2012 May;33(5):1002.e17-27.
  • Oddi D., Crusio W.E., D’Amato F.R., Pietropaolo S. Monogenic mouse models of social dysfunction: Implications for autism. Behav Brain Res. 2013 Aug 15;251:75-84
  • Pietropaolo S., Feldon J., Yee B.K. Environmental enrichment eliminates the anxiety phenotypes in a triple transgenic mouse model of Alzheimer’s disease. Cogn Affect Behav Neurosci. 2014 Feb 4. Sep;14(3):996-1008
  • *Hebert B., *Pietropaolo S., Meme S., Laudier B., Doisne N., Quartier A., Lefeuvre S., Got L., Cahard D., Laumonnier F., Crusio W., Pichon J., Menuet A., Perche O., Briault S. Rescue of Fragile-X Syndrome phenotypes in Fmr1-KO mice by a BKCa channel opener molecule; Orphanet journal of rare disease, 2014 Aug 1;9:124 [* equal contribution]
  • Pietropaolo S., Goubran M.G., Joffre C., Aubert A., Lemaire-Mayo V., Crusio W.E., Layé S. Dietary supplementation of omega-3 fatty acids rescues fragile X phenotypes in Fmr1-Ko mice. Psychoneuroendocrinology. 2014 Nov;49:119-29
  • Zhang Y., Bonnan A., Bony G., Ferezou I., Pietropaolo S., Ginger M., Sans N., Rossier J., Oostra B., LeMasson G., Frick A. Dendritic channelopathies contribute to neocortical and sensory hyperexcitability in Fmr1(-/y) mice. Nat Neurosci. 2014 Dec;17(12):1701-9
  • Oddi D., Subashi E., Middei S., Bellocchio L., Lemaire-Mayo V., Guzmán M., Crusio W.E., D’Amato F.R.*, Pietropaolo S.* Early Social Enrichment Rescues Adult Behavioral and Brain Abnormalities in a Mouse Model of Fragile X Syndrome. Neuropsychopharmacology. 2015 Mar 13;40(5):1113-22 [* equal contribution]
  • Pietropaolo S.*, Bellocchio L.*, Ruiz-Calvo A., Cabanas M., Du Z., Guzmán M., Garret M., Cho Y.H. Chronic cannabinoid receptor stimulation selectively prevents motor impairments in a mouse model of Huntington’s disease. Neuropharmacology. 2015 Feb;89:368-74 [* equal contribution]
  • Lebreton F, Cayzac S, Pietropaolo S., Jeantet Y, Cho YH. Sleep Physiology Alterations Precede Plethoric Phenotypic Changes in R6/1 Huntington’s Disease Mice. PLoS One. 2015 May 12;10(5):e0126972
  • Ragot, A., Pietropaolo S., Vincent, J.,Delage, P., Zhang, H., Allinquant, B., Leinekugel, X., Fischer, A., Cho, Y. Genetic deletion of the Histone Deacetylase 6 exacerbates selected behavioral deficits in the R6/1 mouse model for huntington’s disease. Brain Behav. 2015 Sep;5(9):e00361.