Institut de Neurosciences Cognitives et Intégratives d'Aquitaine (UMR5287)

Aquitaine Institute for Cognitive and Integrative Neuroscience



INCIA - UMR 5287- CNRS
Université de Bordeaux

Zone nord Bat 2 2ème étage
146, rue Léo Saignat
33076 Bordeaux cedex
France

Téléphone 05.57.57.15.51
Télécopie 05.56.90.14.21

Supervisory authorities

CNRS Ecole Pratique des Hautes Etudes Université de Bordeaux

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Neurocampus Unitéde Formation de Biologie

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Pietropaolo Susanna

by Loïc Grattier - published on , updated on

CR1 - CNRS

Contact:
susanna.pietropaolo@u-bordeaux.fr
+33 (0)5 40 00 87 48

Site : Talence

Team:
Neurobiology of behavior

Domain:
Behavioral genetics of mouse models of neuropsychiatric disorders

Research axis:

  • Genetic and neural bases of social behaviors: affiliation, aggression, communication, sexual behavior, mother-infant interactions
  • Gene-environment interactions in animal models of social disorders

Scientific expertise:

  • Mouse behavior
  • Mouse models of neuropsychiatric disorders

Projects:

  • Autistic-like social and cognitive deficits in the Fmr1-KO mouse line: neurobiological and therapeutical applications
  • The role of the endocannabinoid system in the modulation of social behaviors
  • Social deficits as early markers of neuropathology in genetic mouse models of neurodegenerative disorders
  • Maternal enrichment as a treatment for the behavioral deficits of the Fmr1-KO mouse
  • The impact of omega-3 fatty acids dietary enrichment in genetic mouse models of social disorders

Collaborations:

- Prof. Fernando Colmenares at the Department of Psychobiology, Complutense University of Madrid.
- Dr. Andreas Frick at the cortical plasticity laboratory, Neurocentre Magendie, Bordeaux, France.
- Dr. Manuel Guzman at the Department of Biochemistry, Complutense University of Madrid.
- Dr. Jose lopez-Moreno at the Department of Psychobiology, Complutense University of Madrid.
- Prof. Maurizio Memo, University of Brescia, Italy.
-Dr. Francesca D’amato at the CNR of Rome.
-Dr. Sophie Layé at Laboratoire Nutrition et Neurobiologie intégrée, INRA, Bordeaux, France.
-Dr. Giovanni Marsicano at the INSERM U862, laboratoire de Physiopathologie de la plasticité neuronale, Bordeaux, France.
- Dr. Silvia Middei, Santa Lucia Foundation of Rome.

Selected Publications:

Pietropaolo S., Delage P., Lebreton F., Crusio W. E., Cho Y. H. Early development of social deficits in APP and APP-PS1 mice. Neurobiology of aging, 2012, 33, May;33(5):1002.e17-27.
Oddi D., Crusio W.E., D’Amato F.R., Pietropaolo S. Monogenic mouse models of social dysfunction: Implications for autism. Behav Brain Res. 2013 Aug 15;251:75-84.
Pietropaolo S., Goubran M.G., Joffre C., Aubert A., Lemaire-Mayo V., Crusio W.E., Layé S. Dietary supplementation of omega-3 fatty acids rescues fragile X phenotypes in Fmr1-Ko mice. Psychoneuroendocrinology. 2014 Nov;49:119-29.

Oddi D., Subashi E., Middei S., Bellocchio L., Lemaire-Mayo V., Guzmán M., Crusio W.E., D’Amato F.R., Pietropaolo S. Early Social Enrichment Rescues Adult Behavioral and Brain Abnormalities in a Mouse Model of Fragile X Syndrome. Neuropsychopharmacology. 2015 Mar 13;40(5):1113-22

Zhang Y., Bonnan A., Bony G., Ferezou I., Pietropaolo S., Ginger M., Sans N., Rossier J., Oostra B., LeMasson G., Frick A. Dendritic channelopathies contribute to neocortical and sensory hyperexcitability in Fmr1(-/y) mice. Nat Neurosci. 2014 Dec;17(12):1701-9.

Publications 2010-2015:

Pietropaolo S., Crusio W.E. Genes and Cognition. 2010. Wiley Interdisciplinary Reviews: Cognitive Science (WIREs Cognitive Science). 2:345-352
Pietropaolo S., Guilleminot A., Martin B., D’Amato F., Crusio W.E. Genetic-background modulation of core and variable autistic-like symptoms in Fmr1 knock-out mice, PLoS One. 2011, 6(2), e17073
Pietropaolo S., Delage P., Cayzac S., Crusio W.E., Cho Y. H. Altered social and non-social behaviors in motor pre-symptomatic R6/1 mice: the importance of sex differences. PLoS One. 2011, 6(2), e17073
Pietropaolo S., Delage P., Lebreton F., Crusio W. E., Cho Y. H. Early development of social deficits in APP and APP-PS1 mice. Neurobiology of aging, 2012, 33, May;33(5):1002.e17-27.
Oddi D., Crusio W.E., D’Amato F.R., Pietropaolo S. Monogenic mouse models of social dysfunction: Implications for autism. Behav Brain Res. 2013 Aug 15;251:75-84.
Pietropaolo S., Feldon J., Yee B.K. Environmental enrichment eliminates the anxiety phenotypes in a triple transgenic mouse model of Alzheimer’s disease.
Cogn Affect Behav Neurosci. 2014 Feb 4. Sep;14(3):996-1008.
*Hebert B., *Pietropaolo S., Meme S., Laudier B., Doisne N., Quartier A., Lefeuvre S., Got L., Cahard D., Laumonnier F., Crusio W., Pichon J., Menuet A., Perche O., Briault S. Rescue of Fragile-X Syndrome phenotypes in Fmr1-KO mice by a BKCa channel opener molecule; Orphanet journal of rare disease, 2014 Aug 1;9:124.
Pietropaolo S., Goubran M.G., Joffre C., Aubert A., Lemaire-Mayo V., Crusio W.E., Layé S. Dietary supplementation of omega-3 fatty acids rescues fragile X phenotypes in Fmr1-Ko mice. Psychoneuroendocrinology. 2014 Nov;49:119-29.
Oddi D., Subashi E., Middei S., Bellocchio L., Lemaire-Mayo V., Guzmán M., Crusio W.E., D’Amato F.R., Pietropaolo S. Early Social Enrichment Rescues Adult Behavioral and Brain Abnormalities in a Mouse Model of Fragile X Syndrome. Neuropsychopharmacology. 2015 Mar 13;40(5):1113-22