Institut de Neurosciences Cognitives et Intégratives d'Aquitaine (UMR5287)

Aquitaine Institute for Cognitive and Integrative Neuroscience

Université de Bordeaux

Zone nord Bat 2 2ème étage
146, rue Léo Saignat
33076 Bordeaux cedex


Supervisory authorities

CNRS Ecole Pratique des Hautes Etudes Université de Bordeaux

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Neurocampus Unitéde Formation de Biologie


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Nargeot Romuald

by Le Ray Didier, Loïc Grattier - published on , updated on

Assitant Professor (MCF) - Université de Bordeaux

+33 (0)5 57 57 47 74

Site : Carreire

Motor neuron and synaptic partners (Motoneurone et partenaires synaptiques - MotoPSyn)

Neuronal basis of learning and memory of goal-directed behavior

Research interests:

  • Learning and Memory
  • Neuronal plasticity
  • Neuromodulation
  • Dopamine
  • Feeding behavior
  • Aplysia

Scientific expertise:

  • Invertebrate learning and memory
  • Sensory-motor integrations
  • Synaptic and cellular properties of central motor pattern generating networks
  • Electrophysiology (extra and intracellular) / Dynamic clamp (neuron/computer interaction)
  • Pharmacology / Electrochemistry
  • Statistical analyses


  • Cellular basis of learning-induced switching from impulsive- to compulsive-like feeding behavior
  • Synaptic and cellular analysis of a decision-making network
  • Dopaminergic modulation of electrical coupling and oscillatory membrane properties in pacemaker neurons
  • Role of calcium dynamic in the oscillatory properties of pacemaker neurons

List of Publications:

  • Nargeot R. , Moulins M. (1997) Sensory-induced plasticity of motor pattern selection in the lobster stomatogastric nervous system. Eur. J. Neurosci. 9, 1636-1645.
  • Nargeot R. , Baxter D.A., Byrne J.H. (1997) Contingent-dependent enhancement of rhythmic motor patterns: An in vitro analogue of operant conditioning. J. Neurosci. 17, 8093-8105.
  • Nargeot R. , Baxter D.A., Byrne J.H. (1999) In vitro analogue of operant conditioning in Aplysia. I. Contingent reinforcement modifies the functional dynamics of an identified neuron. J. Neurosci. 19, 2247-2260.
  • Nargeot R. , Baxter D.A., Byrne J.H. (1999) In vitro analogue of operant conditioning in Aplysia. II. Modifications of the functional dynamics of an identified neuron contribute to motor pattern selection. J. Neurosci. 19, 2261-2272.
  • Nargeot R. , Baxter D.A., Patterson, G.W, Byrne J.H. (1999) Dopaminergic synapses mediate neuronal changes in an analogue of operant conditioning. J. Neurophysiol. 81, 1983-1987.
  • Nargeot R. (2001) Long-lasting reconfiguration of two interacting networks by a cooperation of presynaptic and postsynaptic plasticity. J. Neurosci. 21, 3282-3294.
  • Nargeot R. , Baxter D.A., Byrne J.H. (2002) Functional dynamics in the neural network mediating feeding in Aplysia: role of neuron B52. Neurosci. Lett. 328, 85-88.
  • Nargeot R. (2003) Voltage-dependent switching of sensorimotor integration by a lobster central pattern generator. J. Neurosci. 23, 4803-4808. Rated “must read” by the Faculty of 1000.
  • Nargeot R., Petrissans C., Simmers J. (2007) Behavioral and in vitro correlates of compulsive-like food-seeking induced by operant conditioning in Aplysia. J. Neurosci. 27, 8059-8070.
  • Nargeot R., Le Bon-Jego M. Simmers J. (2009) Cellular and network mechanisms of operant learning-induced compulsive behavior in Aplysia. Curr. Biol. 19, 975-984. Rated “exceptional” by the Faculty of 1000.
  • Nargeot R., Simmers J. (2011) Neural mechanisms of operant conditioning and learning-induced behavioural plasticity in Aplysia. Cell Mol Life Sci 68, 803-816.
  • Nargeot R., Simmers J. (2012) Functional organization and adaptability of a decison-making network in Aplysia. Front Neurosci 6, e113.
  • Bédécarrats A., Cornet C., Simmers J., Nargeot R. (2013) Implication of dopaminergic modulation in operant learning and the induction of compulsive-like feeding behavior in Aplysia. Learn Mem 20, 318-327.
  • Jelescu I.O., Nargeot R., Le Bihan D., Ciobanu L. (2013) Highlighting manganese dynamics in the nervous system of Aplysia californica using MEMRI at ultra-high field. Neuroimage 76, 264-271.
  • Radecki G., Nargeot R., Jelescu I.O., Le Bihan D., Ciobanu L. (2014) Functional magnetic resonance microscopy at single-cell resolution in Aplysia californica. PNAS 111, 8667-8672.
  • Sieling F., Bédécarrats A., Simmers J., Prinz A.A., Nargeot R. (2014). Differential role of nonsynaptic and synaptic plasticity in operant conditioning-induced compulsive behavior. Curr Biol 24, 941-950.
  • Nargeot R., Radecki G., Jelescu I.O., Le Bihan D., Ciobanu L. (2015) L’imagerie fonctionnelle des neurones individuels au sein de réseaux complexes. Med Sci (Paris) 31, 15-17.
  • Nargeot R., Bédécarrats A (2017) Electrical synapses and learning-induced plasticity in motor rhythmogenesis. In: Network functions and plasticity. Ed. J. Jing. Academic Press, UK.
  • Svehla P., Bédécarrats A., Jahn C., Nargeot R., Ciobanu L. (2018) Intracellular manganese enhanced MRI signals reflect the frequency of action potentials in Aplysia neurons. J Neurosci Meth 295, 121-128.
  • Nargeot R., Bédécarrats A (2019) Associative learning in invertebrates. In: Oxford Handbook of Invertebrate Neurobiology. Ed. J.H. Byrne. Oxford University Press, USA. (
  • Nargeot R., Puygrenier L. (2019) Operant learning in invertebrates. In: Reference Module in Life Science. ScienceDirect, Elsevier (
  • Bédécarrats A, Nargeot R. (2020). Gastropod Learning and Memory (Aplysia, Lymnaea, Hermissenda, and Others). In: Oxford Research Encyclopedia of Neuroscience. Ed. M. Sherman. New York and Oxford: Oxford University Press, USA.
  • Bédécarrats, A., Puygrenier, L., Castro O’Byrne, J., Lade, Q., Simmers, J., & Nargeot, R. (2021). Organelle calcium-derived voltage oscillations in pacemaker neurons drive the motor program for food-seeking behavior in Aplysia. eLife, 10, e68651.