Institut de Neurosciences Cognitives et Intégratives d’Aquitaine (UMR5287)

DR2 CNRS, HDR, Team leader

Contact:
mathieu.wolff@u-bordeaux.fr

+33 (0)5 57 57 95 07

Site : Charles Perrens

Team:
Decision and Adaptation

Social:
ResearchGate / Loop / LinkedIn / Google Scholar / Twitter

ORCID: 0000-0003-3037-3038 / Publons

Domain:
Animal cognition and behaviour / Associative learning

Research axis:

• Thalamocortical bases of adaptive behaviors
• Thalamic determinants of cognition

Scientific expertise:

• Integrated study of animal behaviour
• Circuit level analysis
• Functional anatomy

Collaborations:

• Seralynne Vann, Cardiff university, Wales
• Alexander Groh, Heidelberg university, Germany
• John Dalrymple-Alford, Psychology Department, University of Canterbury, Christchurch, New Zealand
• Frédéric Gambino, IINS, France
• Lisa Roux, IINS, France
• Erik J Kremer, Institut de Génétique Moléculaire de Montpellier

Funding:

• ANR PRC "THALACOR" (2022-2026, 257k€, Coordinator) Thalamocortical control of voluntary actions

• Bordeaux Neurocampus Seed Project (2020); 20k€, Corticothalamic dynamics underlying decisions in uncertain environments (Partner: Karine Guillem)

• Independent Investigator NARSAD Grant (2017-2019), 100k$, Thalamic determinants of Schizophrenia Pathophysiology

• ANR PRC "THALAME" (2015-2019, 93k€, Partner)

• ANR "GOAL" (2015-2018, 160k€, Associated Researcher)

Selected publications:

• Wolff M, Morceau S, Folkard R, Martin-Cortecero J, Groh A (2021) A thalamic bridge from sensory perception to cognition. Neurosci Biobehav Rev 120:222–235.
   check at INCIA website

• Fresno V, Parkes S, Faugère A, Coutureau E, Wolff M (2019) A thalamocortical circuit for updating action-outcome associations. e46187. doi: 10.7554/eLife.46187.
   check on the Société des Neurosciences (FR)
   or at Bordeaux Neurocampus or INCIA (En)

• Wolff M, Vann SD (2019) The Cognitive Thalamus as a Gateway to Mental Representations. J Neurosci 39:3-14.
   Bordeaux Neurocampus or INCIA (En)

• Alcaraz F, Fresno V, Marchand AR, Kremer EJ, Coutureau E, Wolff M. (2018)Thalamocortical and corticothalamic pathways differentially contribute to goal-directed behaviors in the rat.Elife. 2018 Feb 6;7. pii: e32517. doi: 10.7554/eLife.32517.
   check at the INSB (CNRS) (FR)
   or at INCIA (En)
   Comment le cerveau décide ? (FR)

• Alcaraz F, Marchand AR, Courtand G, Coutureau E, Wolff M (2016) Parallel inputs from the mediodorsal thalamus to the prefrontal cortex in the rat. Eur J Neurosci 44:1972-1986.

• Alcaraz F, Marchand AR, Vidal E, Guillou A, Faugere A, Coutureau E, Wolff M (2015) Flexible Use of Predictive Cues beyond the Orbitofrontal Cortex: Role of the Submedius Thalamic Nucleus. J Neurosci 35:13183-13193.
   National press release from the CNRS (FR)
   Science&Avenir

• Wolff M, Alcaraz F, Marchand AR, Coutureau E (2015) Functional heterogeneity of the limbic thalamus: From hippocampal to cortical functions. Neurosci Biobehav Rev 54:120-130.

• Dalrymple-Alford JC, Harland B, Loukavenko EA, Perry B, Mercer S, Collings DA, Ulrich K, Abraham WC, McNaughton N, Wolff M (2015) Anterior thalamic nuclei lesions and recovery of function: Relevance to cognitive thalamus. Neurosci Biobehav Rev 54:145-160.

• Marchand A, Faugere A, Coutureau E, Wolff M (2014) A role for anterior thalamic nuclei in contextual fear memory. Brain Struct Funct 219:1575-1586.

• Dupire A, Kant P, Mons N, Marchand AR, Coutureau E, Dalrymple-Alford J, Wolff M (2013) A role for anterior thalamic nuclei in affective cognition: Interaction with environmental conditions. Hippocampus 23:392-404.

Publications 2006-2021:

2021

• Dopeso-Reyes IG, Wolff M, Andrews MR, Kremer EJ (2021) Editorial: Tropism, Mapping, Modeling, or Therapy Using Canine Adenovirus Type 2 (CAV-2) Vectors in the CNS. Front Mol Neurosci 14

• Wolff M, Morceau S, Folkard R, Martin-Cortecero J, Groh A (2021) A thalamic bridge from sensory perception to cognition. Neurosci Biobehav Rev 120:222–235.

2020

• Quet E, Majchrzak M, Cosquer B, Morvan T, Wolff M, Cassel J-C, Pereira de Vasconcelos A, Stéphan A (2020) The reuniens and rhomboid nuclei are necessary for contextual fear memory persistence in rats. Brain Struct Funct Available at: https://doi.org/10.1007/s00429-020-02048-z [Accessed March 12, 2020].

2019

• Fresno V, Parkes S, Faugère A, Coutureau E, Wolff M (2019) A thalamocortical circuit for updating action-outcome associations. e46187. doi: 10.7554/eLife.46187.

• Wolff M, Vann SD (2019) The Cognitive Thalamus as a Gateway to Mental Representations. J Neurosci 39:3-14.

• Morceau S, Piquet R, Wolff M, Parkes SL (2019) Targeting reciprocally connected brain regions through CAV-2 mediated interventions. Frontiers in Molecular Neuroscience, doi: 10.3389/fnmol.2019.00303.

• Bonhomme D, Alfos S, Webster SP, Wolff M, Pallet V, Touyarot K (2019) Vitamin A deficiency impairs contextual fear memory in rats: Abnormalities in the glucocorticoid pathway. J Neuroendocrinol. 15:e12802. doi: 10.1111/jne.12802

  ---

2018

• Alcaraz F, Fresno V, Marchand AR, Kremer EJ, Coutureau E, Wolff M. (2018)Thalamocortical and corticothalamic pathways differentially contribute to goal-directed behaviors in the rat. Elife. 2018 Feb 6;7. pii: e32517. doi: 10.7554/eLife.32517.

• Parkes SL, Ravassard PM, Cerpa JC, Wolff M, Ferreira G, Coutureau E. (2018) Insular and Ventrolateral Orbitofrontal Cortices Differentially Contribute to Goal-Directed Behavior in Rodents. Cereb Cortex. 2018 Jul 1;28(7):2313-2325. doi: 10.1093/cercor/bhx132.

2016

• Alcaraz F, Marchand AR, Courtand G, Coutureau E, Wolff M (2016a) Parallel inputs from the mediodorsal thalamus to the prefrontal cortex in the rat. Eur J Neurosci 44:1972-1986.
• Alcaraz F, Naneix F, Desfosses E, Marchand AR, Wolff M*, Coutureau E* (2016b) Dissociable effects of anterior and mediodorsal thalamic lesions on spatial goal-directed behavior. Brain Struct Funct 221:79-89. * Contributed equally.
• Loukavenko EA*, Wolff M*, Poirier GL, Dalrymple-Alford JC (2016) Impaired spatial working memory after anterior thalamic lesions: recovery with cerebrolysin and enrichment. Brain Struct Funct 221:1955-1970. *Contributed equally.

2015

• Alcaraz F, Marchand AR, Vidal E, Guillou A, Faugere A, Coutureau E, Wolff M (2015) Flexible Use of Predictive Cues beyond the Orbitofrontal Cortex: Role of the Submedius Thalamic Nucleus. J Neurosci 35:13183-13193.
• Dalrymple-Alford JC, Harland B, Loukavenko EA, Perry B, Mercer S, Collings DA, Ulrich K, Abraham WC, McNaughton N, Wolff M (2015) Anterior thalamic nuclei lesions and recovery of function: Relevance to cognitive thalamus. Neurosci Biobehav Rev 54:145-160.
• Wolff M, Alcaraz F, Marchand AR, Coutureau E (2015a) Functional heterogeneity of the limbic thalamus: From hippocampal to cortical functions. Neurosci Biobehav Rev 54:120-130.
• Wolff M, Faugere A, Desfosses E, Coutureau E, Marchand AR (2015b) Mediodorsal but not anterior thalamic nuclei lesions impair acquisition of a conditional discrimination task. Neurobiol Learn Mem 125:80-84.

2014

• Marchand A, Faugere A, Coutureau E, Wolff M (2014) A role for anterior thalamic nuclei in contextual fear memory. Brain Struct Funct 219:1575-1586.

2013

• Dupire A, Kant P, Mons N, Marchand AR, Coutureau E, Dalrymple-Alford J, Wolff M (2013) A role for anterior thalamic nuclei in affective cognition: Interaction with environmental conditions. Hippocampus 23:392-404.
• Mendez-Lopez M, Arias JL, Bontempi B, Wolff M (2013) Reduced cytochrome oxidase activity in the retrosplenial cortex after lesions to the anterior thalamic nuclei. Behav Brain Res 250C:264-273.
• Moreau PH, Tsenkina Y, Lecourtier L, Lopez J, Cosquer B, Wolff M, Dalrymple-Alford J, Cassel JC (2013) Lesions of the anterior thalamic nuclei and intralaminar thalamic nuclei: place and visual discrimination learning in the water maze. Brain Struct Funct 218:657-667.

2006-2012

• Porte Y, Trifilieff P, Wolff M, Micheau J, Buhot MC, Mons N (2011) Extinction of spatial memory alters CREB phosphorylation in hippocampal CA1. Hippocampus 21:1169-1179.
• Segu L, Lecomte MJ, Wolff M, Santamaria J, Hen R, Dumuis A, Berrard S, Bockaert J, Buhot MC, Compan V (2010) Hyperfunction of muscarinic receptor maintains long-term memory in 5-HT4 receptor knock-out mice. PLoS One 5:e9529.
• Lopez J, Wolff M, Lecourtier L, Cosquer B, Bontempi B, Dalrymple-Alford J, Cassel JC (2009) The intralaminar thalamic nuclei contribute to remote spatial memory. J Neurosci 29:3302-3306.
• Will B, Dalrymple-Alford J, Wolff M, Cassel JC (2008a) Reflections on the use of the concept of plasticity in neurobiology. Translation and adaptation by Bruno Will, John Dalrymple-Alford, Mathieu Wolff and Jean-Christophe Cassel from J. Paillard, J Psychol 1976;1:33-47. Behav Brain Res 192:7-11.
• Will B, Dalrymple-Alford J, Wolff M, Cassel JC (2008b) The concept of brain plasticity—Paillard’s systemic analysis and emphasis on structure and function (followed by the translation of a seminal paper by Paillard on plasticity). Behav Brain Res 192:2-7.
• Wolff M, Gibb SJ, Cassel JC, Dalrymple-Alford JC (2008a) Anterior but not intralaminar thalamic nuclei support allocentric spatial memory. Neurobiol Learn Mem 90:71-80.
• Wolff M, Loukavenko EA, Will BE, Dalrymple-Alford JC (2008b) The extended hippocampal-diencephalic memory system: enriched housing promotes recovery of the flexible use of spatial representations after anterior thalamic lesions. Hippocampus 18:996-1007.
• Loukavenko EA, Ottley MC, Moran JP, Wolff M, Dalrymple-Alford JC (2007) Towards therapy to relieve memory impairment after anterior thalamic lesions: improved spatial working memory after immediate and delayed postoperative enrichment. Eur J Neurosci 26:3267-3276.
• Gibb SJ, Wolff M, Dalrymple-Alford JC (2006) Odour-place paired-associate learning and limbic thalamus: comparison of anterior, lateral and medial thalamic lesions. Behav Brain Res 172:155-168.
• Wolff M, Gibb SJ, Dalrymple-Alford JC (2006) Beyond spatial memory: the anterior thalamus and memory for the temporal order of a sequence of odor cues. J Neurosci 26:2907-2913.