Institut de Neurosciences Cognitives et Intégratives d'Aquitaine (UMR5287)

Aquitaine Institute for Cognitive and Integrative Neuroscience



INCIA - UMR 5287- CNRS
Université de Bordeaux

Zone nord Bat 2 2ème étage
146, rue Léo Saignat
33076 Bordeaux cedex
France

Téléphone 05.57.57.15.51
Télécopie 05.56.90.14.21

Supervisory authorities

CNRS Ecole Pratique des Hautes Etudes Université de Bordeaux

Our partners

Neurocampus Unitéde Formation de Biologie

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Branchereau Pascal

by Loïc Grattier - published on , updated on

JPEG Professor of Neurosciences - Université de Bordeaux (PR1) - HDR

Contact:
pascal.branchereau@u-bordeaux.fr
+33 (0)5 57 57 15 53

Site : Carreire

Team:
Development of spinal motor networks in normal and pathologic conditions

Domain:
Spinal cord / Development / SLA / Electrophysiology / Ex vivo experiments

Research axis:

  • Development of mouse spinal motoneurons / Ontogenic changes in chloride homeostasis
  • Early changes in spinal motor networks from amyotrophic lateral sclerosis (ALS) mouse models
  • Mechanisms involved in the genesis of spontaneous activity in spinal motor networks

Scientific expertise:

  • Spinal cord development
  • Electrophysiological mechanisms
  • Neuroanatomical changes

Projects:

  • Early deficits in spinal motoneurons in ALS mouse models
  • Role of the first functional pioneer GABAergic interneuron (INs) in the genesis of the spinal cord electrical activity

Collaborations:

  • Pascal Legendre
  • Luc Dupuis
  • Daniel Cattaert
  • Timothée Lévi
  • Jean-Luc Gaiarsa / Christophe Porcher
  • Stephen J. Moss

Grants:

  • Fédération pour la Recherche sur Le Cerveau (FRC)
  • Association pour la Recherche sur la Sclérose Latérale Amyotrophique (ARSLA)

Selected publications:

  • Czarnecki A1, Le-Corronc H1, Rigato C, Lebras B, Couraud F, Scain A-L, Allain A-E, Mangin J-M, Branchereau P1*, Legendre P1*. Acetylcholine controls GABA-, glutamate- and glycine-dependent giant depolarizing potentials that govern spontaneous motoneuron activity at the onset of synaptogenesis in the mouse embryonic spinal cord. Journal of Neuroscience (2014) 34:6389-404. 1Equal contribution *co-corresponding authors.
  • Martin E, Cazenave W, Cattaert D, Branchereau P. Embryonic alteration of motoneuronal morphology induces hyperexcitability in the mouse model of Amyotrophic Lateral Sclerosis. Neurobiology of Disease (2013) 54:116-26.
  • Branchereau P1, Cattaert D1, Delpy A, Allain A-E, Martin E, Meyrand P. Depolarizing GABA/glycine synaptic events switch from excitation to inhibition during frequency increases. Scientific Reports (2016) Feb 25;6:21753.
  • Boeri J, Le Corronc H, Lejeune FX, Le Bras B, Mouffle C, Angelim MKSC, Mangin JM, Branchereau P, Legendre P, Czarnecki A. Persistent sodium current drives excitability of immature Renshaw cells in early embryonic spinal networks. Journal of Neuroscience (2018) 38(35):7667-7682.