Jérôme Badaut, PhD
CR1, CNRS
Contact:
Jerome.badaut@u-bordeaux.fr
+33 (0)5 57 57 17 35
Site : Carreire
Team:
Domain:
Neurovascular unit physiology/ traumatic brain injury/ stroke/ edema/ astrocytes
Research axis:
- Neurovascular unit dysfunctions at longterm after juvenile traumatic brain injury
- Role of the astrocyte network in Edema process
Scientific expertise:
- In vivo models of traumatic brain injury
- Immunohistochemistry and image analysis
- RNAi in vivo
- Astrocyte and organotypic cultures
Projects:
The neurovascular unit (NVU) is composed of cerebral blood vessels, neurons, and scattered in between them, an astrocyte sheath. The homeostasis of this unit is critical for normal brain function and activity, especially the maintenance of blood-brain barrier (BBB) properties that regulate entry of blood components and clearance of brain waste. The astrocyte network contributes to water and ion homeostasis, as well as brain energy metabolism.
Our research is focused on the changing physiological properties of the NVU after traumatic brain injury (TBI). TBI can occur at any point in a person’s lifetime, affects a large number of soldiers in the battlefield, and is known to result in both short- and long-term consequences. The functional and molecular consequences after TBI might be a result of the changing NVU properties observed near the TBI injury site, and at a distance from the site of the impact. We are currently investigating the molecular mechanisms behind TBI-induced dysfunctions in NVU homeostasis using a rodent model. We evaluate these changes using magnetic resonance imaging (MRI), behavioral testing paradigms, and histological and molecular biology techniques to address specific protein targets at the NVU interface (for example: aquaporins…). We hope our understanding of these basic mechanisms will help to generate new target-specific drugs to promote functional recovery of individuals affected by brain injury.
Grants:
- ERA-NET NEURON, CnsAflame
- R01 HD061946, NIH/NICHD
- ERA-NET NEURON, TRAINS
- Fondation des Gueules cassees
- ANR-TRAIL Vasc-TBI
Selected Publications:
1) A.M. FUKUDA, A. ADAMI, V. POP, J.A. BELLONE, J.S. COATS, R.E. HARTMAN, S. ASHWAL, A. OBENAUS, J. BADAUT. Posttraumatic reduction of edema with aquaporin-4 RNA interference improves acute and chronic functional recovery. J of Cereb Blood flow and Metab 2013 Oct;33(10):1621-32
2) V. POP, D.W. SORENSEN, J.E. KAMPER, D. O. AJAO, M. P. MURPHY, E. HEAD, R.E. HARTMAN, J. BADAUT (2013) Early brain injury alters the blood-brain barrier phenotype in parallel with beta-amyloid and cognitive changes in adulthood. J Cereb Blood Flow Metab Feb;33(2):205-14.
3) J. ZHANG, J.BADAUT, R. E. HARTMAN, A. OBENAUS, J. TANG, W.J. PEARCE. The Vascular Neural Network: Old Wine in a New Bottle? Nature Neurology Review. 2012 Nov 13;8(12):711-6
4) D.O. AJAO, V. POP, J. E. KAMPER, A. ADAMI, E. RUDOBECK, L. HUANG, R. VLKOLINSKY, R. E. HARTMAN, S. ASHWAL, A. OBENAUS, J. BADAUT Traumatic brain injury in young rats leads to progressive behavioral deficits coincident with altered myelin in adulthood. J. Neurotrauma, (Jul);29(11):2060-74
5) J.E. KAMPER, V. POP V, A.M. FUKUDA, D.O. AJAO, R.E. HARTMAN, J. BADAUT. Juvenile traumatic brain injury evolves into a chronic brain disorder: Behavioral and histological changes over 6 months. Exp Neurol. 2013 Sep 25;250C: 8-19