Institut de Neurosciences Cognitives et Intégratives d'Aquitaine (UMR5287)

Aquitaine Institute for Cognitive and Integrative Neuroscience

Université de Bordeaux

Zone nord Bat 2 2ème étage
146, rue Léo Saignat
33076 Bordeaux cedex


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CNRS Ecole Pratique des Hautes Etudes Université de Bordeaux

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Neurocampus Unitéde Formation de Biologie


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Dr de Vellis (UCLA) to visit the INCIA

by Loïc Grattier - published on , updated on

Doctor Jean De-Vellis
Director, Center for Developmental Neurobiology
Distinguished Professor Neurobiology
Professor Psychiatry and Biobehavioral Sciences

Los Angeles (THAT, the USA)

Will give a conference
Friday, October 9th, 2015
At 2 pm
to the INCIA UMR CNRS 5287(INCIA UMR National Center for Scientific Research 5287)
( Site of Carreire, north zone, pack saddle. 2A, 2eme floor)

Invitation: Jérôme Badaut


Research Interest: Regulation of Gene Expression in Brain Cells My laboratory is interested

in the molecular mechanisms controlling neuronal and glial cells interaction during

development. What are the environmental signals and the mechanisms that regulate the

system events that fashion the progression of the multipotential neuroepithelial cells into

the enormous cellular phenotypic diversity of the nervous sytems? We have developed rat

brain culture system capable of recapitulating important developmental events of glial

cells and neurons. These model systems have been used to identify growth factors and

other agents that regulated proliferation, survival and differentiation in a cell specific

manner. In this way, many environmental signals and numerous cell processes have been

correlated with the appearance of different neural phenotypes. The expression of

regulatory genes such as transcription factors particularly those who are lineage

restricted, are regulated in a combinatorial manner by growth factors, hormones,

neurotransmitters and cytokines. This research has helped define at the molecular level the

plasticity of brain cells and their potential for regeneration. Regeneration in

dysmyelinating rat mutants has been achieved by transplantation of glia progenitor cells.

A main focus of the laboratory is on development of the oligodendrocytes, the myelin

forming cells in the central nervous system and a key cell in brain iron homeostasis. The

growth factors and other agents studied include neurotrophins, (NGF, BDNF, NT3) basis

fibroblast growth factor, platelet-derived growth factor, transferrin, glucocorticoid

hormones, retinoic acid and various cytokines known to be active in the immune system.

Recent findings suggest that astrocytes microglia and neurons provide key signals for

oligodendrocyte survival and differentiation.