Technician, Université de Bordeaux
Contact:
william.cazenave@u-bordeaux.fr
+33 (0)5 40 00 25 72
Team:
Development of spinal motor networks in normal and pathologic conditions
Domain:
Molecular biology / Biochemistry / Immunohistochemistry / Development
Research axis:
- Development of mouse spinal motoneurons / Ontogenic changes in chloride homeostasis
- Early changes in spinal motor networks from amyotrophic lateral sclerosis (ALS) mouse models
- Mechanisms involved in the genesis of spontaneous activity in spinal motor networks
Scientific expertise:
- genotyping
- RT-PCR, qPCR
- Western blotting
- Dissection of mouse embryo
- Immunocytochemistry
Projects:
- Early deficits in spinal motoneurons in ALS mouse models
- Role of the first functional pioneer GABAergic interneuron in the genesis of the spinal cord electrical activity
Selected publications:
- Allain A-E, Cazenave W, Delpy A, Exertier P, Barthe C, Meyrand P, Cattaert D, Branchereau P. Early non synaptic glycine release allows the maturation of neuronal networks by controlling KCC2 expression. Developmental Neurobiology (2015) Oct 27. doi: 10.1002/dneu.22358. [Epub ahead of print]
- Martin E, Cazenave W, Cattaert D, Branchereau P. Embryonic alteration of motoneuronal morphology induces hyperexcitability in the mouse model of Amyotrophic Lateral Sclerosis. Neurobiology of Disease (2013)