Institut de Neurosciences Cognitives et Intégratives d'Aquitaine (UMR5287)

Aquitaine Institute for Cognitive and Integrative Neuroscience



INCIA - UMR 5287- CNRS
Université de Bordeaux

Zone nord Bat 2 2ème étage
146, rue Léo Saignat
33076 Bordeaux cedex
France

Téléphone 05.57.57.15.51
Télécopie 05.56.90.14.21

Supervisory authorities

CNRS Ecole Pratique des Hautes Etudes Université de Bordeaux

Our partners

Neurocampus Unitéde Formation de Biologie

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GDR Robotique GDR Mémoire GDR Multi-électrodes

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Cazenave William

published on , updated on

Technician, Université de Bordeaux

Contact:
william.cazenave@u-bordeaux.fr
+33 (0)5 57 57 15 53

Site : Carreire

Team:
Development of spinal motor networks in normal and pathologic conditions

Domain:
Molecular biology / Biochemistry / Immunohistochemistry / Development

Research axis:

  • Development of mouse spinal motoneurons / Ontogenic changes in chloride homeostasis
  • Early changes in spinal motor networks from amyotrophic lateral sclerosis (ALS) mouse models
  • Mechanisms involved in the genesis of spontaneous activity in spinal motor networks

Scientific expertise:

  • Western blotting
  • Immunohistochemistry
  • -* RT-PCR, qPCR

Projects:

  • Early deficits in spinal motoneurons in ALS mouse models
  • Role of the first functional pioneer GABAergic interneuron in the genesis of the spinal cord electrical activity

Selected publications:

  • Allain A-E, Cazenave W, Delpy A, Exertier P, Barthe C, Meyrand P, Cattaert D, Branchereau P. Early non synaptic glycine release allows the maturation of neuronal networks by controlling KCC2 expression. Developmental Neurobiology (2015) Oct 27. doi: 10.1002/dneu.22358. [Epub ahead of print]
  • Martin E, Cazenave W, Cattaert D, Branchereau P. Embryonic alteration of motoneuronal morphology induces hyperexcitability in the mouse model of Amyotrophic Lateral Sclerosis. Neurobiology of Disease (2013)