Institut de Neurosciences Cognitives et Intégratives d'Aquitaine (UMR5287)

Aquitaine Institute for Cognitive and Integrative Neuroscience



INCIA - UMR 5287- CNRS
Université de Bordeaux

Zone nord Bat 2 2ème étage
146, rue Léo Saignat
33076 Bordeaux cedex
France

Téléphone 05.57.57.15.51
Télécopie 05.56.90.14.21

Supervisory authorities

CNRS Ecole Pratique des Hautes Etudes Université de Bordeaux

Our partners

Neurocampus Unitéde Formation de Biologie

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Bertrand Sandrine

by Loïc Grattier - published on , updated on

CR1, CNRS

Contact:
sandrine.bertrand@u-bordeaux2.fr
+33 (0)5 57 57 95 43

Site : Carreire

Team:
Coordinations and Plasticities of Spinal Generators

Domain:
Motor Systems / Motor Neuron / Spinal Neural Networks

Research axis:

  • Activity-dependent synaptic plasticity in spinal motor networks
  • Neuromodulation in spinal motor networks
  • Pathophysiology of spinal motor networks in ALS models

Scientific expertise:

  • In vitro isolated neonatal rodent spinal cord preparations
  • Spinal cord slices
  • Electrophysiology (patch clamp), neuropharmacology
  • Calcium imaging
  • Motoneuron culture

Projects:

  • Project 1: Activity dependent plasticity of reticulomotoneuronal synapses.
  • Project 2: Spike timing dependent plasticity in motoneurons
  • Project 3: Cholinergic spinal interneurons
  • Project 4: The muscarinic system in ALS models

Collaborations:

  • Prof. Jean-Claude Lacaille. University of Montreal, Montreal Canada

Selected Publications:

  • G.Y.K. Ng, S. Bertrand, R. Sullivan, N. Ethier, J. Wang, J. Yergey, M. Belley, L. Trimble, K. Bateman, K. Metters, G. P. O’Neill, J.-C. Lacaille, and T. E. Hébert. γ-aminobutyric acid type B receptors with specific heterodimer composition and postsynaptic actions in hippocampal neurons are targets of anticonvulsant gabapentin action. (2001) Mol. Pharmacol. 59 :144-152.
  • Derjean D, *Bertrand S, Le Masson G, Landry M, Morisset V and Nagy F. Multiple states in spinal dorsal horn neurons : switch under dynamic balance of metabotropic controls. (2003) Nature Neuroscience. 6 :274-281.*Co-first authors.
  • Derjean D, Bertrand S, Nagy F, Shefchyk SJ. Plateau potentials and membrane oscillations in parasympathetic preganglionic neurons and intermediolateral neurons in the rat lumbo-sacral spinal cord. (2005) J Physiol. 563:583-596.
  • Barrière G, Tartas M, Cazalets J-R and Bertrand S. S. Interplay between neuromodulator-induced switching of short-term plasticity at sensorimotor synapses in the neonatal rat spinal cord. (2008) Journal of Physiol. (London) 586.7 : 1903-1920.
  • Tartas M, Morin F, Goillandeau M, Lacaille JC, Jean-René Cazalets JR and Bertrand S. S. Noradrenergic modulation of intrinsic and synaptic properties of lumbar motoneurons in the neonatal rat spinal cord. (2010) Frontiers in Neural Circuits. Mar 8, 4 :4.

Grants:

  • French Association against myopathies (AFM)
  • PICS CNRS (collaboration JC Lacaille UdM, Montréal)
  • Aquitany region: Plasticité Physiologique et Physiopathologique des Réseaux Neuronaux.
  • Accords CNRS/IRSC (France/Canada)

Publications 2006-2011:

  • Barrière G, Tartas M, Cazalets J-R and Bertrand S. S. Interplay between neuromodulator-induced switching of short-term plasticity at sensorimotor synapses in the neonatal rat spinal cord. (2008) Journal of Physiol. (London) 586.7 : 1903-1920.
  • Pape J-R, Bertrand S. S, Lafon P, Odessa M-F, Chaigniau M and Garret M. Expression of GABAA receptor α3-, θ-, and ε-subunits during rat CNS development. (2009) Neuroscience. 160 (1) :85-96.
  • Fossat P, Dobremez E, Bouali-Benazzouz R, Favereaux A, Bertrand S. S, Kilk K, Cazalets J-R, Langel U, Landry M and Nagy F. Knockdown of L Calcium Channel Subtypes: Differential Effects in Neuropathic Pain. (2010) Journal. Neuroscience. 30(3):1073-85.
  • Tartas M, Morin F, Goillandeau M, Lacaille JC, Jean-René Cazalets JR and Bertrand S. S. Noradrenergic modulation of intrinsic and synaptic properties of lumbar motoneurons in the neonatal rat spinal cord. (2010) Frontiers in Neural Circuits. Mar 8, 4 :4.