Institut de Neurosciences Cognitives et Intégratives d'Aquitaine (UMR5287)

Aquitaine Institute for Cognitive and Integrative Neuroscience



INCIA - UMR 5287- CNRS
Université de Bordeaux

Zone nord Bat 2 2ème étage
146, rue Léo Saignat
33076 Bordeaux cedex
France

Téléphone 05.57.57.15.51
Télécopie 05.56.90.14.21

Supervisory authorities

CNRS Ecole Pratique des Hautes Etudes Université de Bordeaux

Our partners

Neurocampus Unitéde Formation de Biologie

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Bertrand Sandrine

by Loïc Grattier - published on , updated on

Research Director (DR2), CNRS

Contact:
sandrine.bertrand@u-bordeaux.fr
+33 (0)5 57 57 95 43

Site : Carreire


Team:
Motor neuron and synaptic partners (Motoneurone et partenaires synaptiques - MotoPSyn)

Domain:
Motor Systems / Motor Neuron / Spinal Neural Networks

Research axis:

  • Activity-dependent synaptic plasticity in spinal motor networks
  • Pathophysiology of spinal motor networks in ALS models
  • Sympathetic preganglionic neurons

Scientific expertise:

  • In vitro isolated neonatal rodent spinal cord preparations
  • Spinal cord slices
  • Electrophysiology (patch clamp)
  • Immunohistochemistry, molecular biology, genomic

Projects:

  • P2X4 receptors in amyotrophic lateral sclerosis.
  • Are CSF-connecting neurons part of the sympathetic nervous system ?
  • Impact of a short motor training on the nervous motor system and muscles during development
  • The sympathetic preganglionic neurons in amyotrophic lateral sclerosis

Collaborations:

  • Pr. Florence Perrin, MMDN, Montpellier, France
  • Dr. Eric Boué-Grabot, IMN CNRS, Bordeaux, France
  • Pr. Susana Lima, Champalimaud Institute for the Unknown, Lisbon, Portugal

Selected Publications:

  • G.Y.K. Ng, S. Bertrand, R. Sullivan, N. Ethier, J. Wang, J. Yergey, M. Belley, L. Trimble, K. Bateman, K. Metters, G. P. O’Neill, J.-C. Lacaille, and T. E. Hébert. γ-aminobutyric acid type B receptors with specific heterodimer composition and postsynaptic actions in hippocampal neurons are targets of anticonvulsant gabapentin action. (2001) Mol. Pharmacol. 59 :144-152.
  • Derjean D, *Bertrand S, Le Masson G, Landry M, Morisset V and Nagy F. Multiple states in spinal dorsal horn neurons : switch under dynamic balance of metabotropic controls. (2003) Nature Neuroscience. 6 :274-281.*Co-first authors.
  • Milan L, Courtand G, Cardoit L, Masmejean F, Barrière G, Cazalets JR, Garret M, and Bertrand S.S. Age-related changes in pre- and post-synaptic partners of the cholinergic C-boutons in wild-type and SOD1G93A lumbar motoneurons. (2015) Plos One. 10(8).
  • Lenschow C, Cazalets JR and Bertrand S.S. Distinct and developmentally regulated activity-dependent plasticity at descending glutamatergic synapses on flexor and extensor motoneurons. (2016) Scientific Reports. Jun 22;6:28522.
  • Sourioux M, Bertrand S.S* and Cazalets JR*. Cholinergic-mediated coordination of rhythmic sympathetic and motor activities in the newborn rat spinal cord. (2018) PloS Biol. Jul 9;16(7). *Co-last authors.

Grants:

  • ANR SYMPA-cNeurons. PI. Collaboration N. Wanaverbecq, INT, Marseille (2021 - 2025).
  • IEA CNRS. Collaboration S. Lima, Portugal, 2021 – 2022.
  • ANR P2XforALS. Partner. Collaboration E Boué-Grabot, IMN, Bordeaux (2021 - 2024)
  • Fonds France Canada pour la Recherche (FFCR). Collaboration Pr. Réjean Dubuc, Université de Montréal (2020 – 2021).
  • Association pour la recherche sur la sclérose latérale amyotrophique et autres maladies du motoneurone (ARSLA) : Aberrant surface P2X4 receptors in serum-derived macrophages of patients with ALS: proof of concept for an early ALS biomarker and role in neuroinflammation. E Boué-Grabot (PI, IMN, Bordeaux), S. Bertrand (coPI) (2019 - 2020)
  • Labex BRAIN, Université de Bordeaux. Collaboration E Boué-Grabot, IMN, Bordeaux (2019 - 2020)
  • Association pour la recherche sur la sclérose latérale amyotrophique et autres maladies du motoneurone (ARSLA) : Unraveling the implication of P2X4 purinoceptors in amyotrophic lateral slerosis (ALS). E Boué-Grabot (PI, IMN, Bordeaux), S. Bertrand (coPI) (2016 - 2017)