Institut de Neurosciences Cognitives et Intégratives d'Aquitaine (UMR5287)

Aquitaine Institute for Cognitive and Integrative Neuroscience



INCIA - UMR 5287- CNRS
Université de Bordeaux

Zone nord Bat 2 2ème étage
146, rue Léo Saignat
33076 Bordeaux cedex
France

Téléphone 05.57.57.15.51
Télécopie 05.56.90.14.21

Supervisory authorities

CNRS Ecole Pratique des Hautes Etudes Université de Bordeaux

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Neurocampus Unitéde Formation de Biologie

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Cazalets Jean-René

PhD, Research Director CNRS

by Loïc Grattier - published on , updated on

Research Director CNRS

Contact:
jean-rene.cazalets@u-bordeaux.fr
+33 (0)5 57 57 46 26

Site : Carreire

Team:
Coordinations and Plasticities of Spinal Generators

Domain:
Motor Systems / Sensori-motor Integrations / Brainstem and Spinal Neural Networks

Research axis:

  • Control of trunk movements in mammalian locomotion
  • Study of cellular basis of locomotion
  • Couplin mechanisms between sensory afferents and dynamic posture

Scientific expertise:

  • Motor rhythm-generating networks
  • Development of neural networks engaged in motor functions
  • In vitro isolated neonatal rodent brainstem-spinal cord preparations
  • Electrophysiology, neuropharmacology
  • Analysis of human motor patterns (electromyography, 3D motion analysis)
  • Modeling of motor activities

Projects:

  • Deciphering the cellular basis of hindlimb locomotor networks in rat
  • Undestanding the role of thoracic networks in locomotor function: activation, properties, synaptic drive.
  • Investigating the role of trunk motion in normal and pathological conditions in humans

Collaborations:

  • Dr Jean-Marie Cabelguen, University Bordeaux
  • Dr Nicholas Mellen, University Louisville

Selected Publications:

  • FALGAIROLLE, M., CECCATO, J.C., HERBIN, M., and CAZALETS, J.R (2011) Metachronal propagation of motor activity, in press, Encyclopedia of Bioscience
  • CECCATO, J.C., DE SEZE, M., AZEVEDO, C., and CAZALETS, J.R., (2009), Comparison of trunk activity during gait initiation and walking in humans. PLoS One, 4: e8193.
  • DE SEZE, M., FALGAIROLLE, M., VIEL, S., ASSAIANTE, C., and CAZALETS, J.R., (2008), Sequential activation of axial muscles during different forms of rhythmic behavior in man. Exp Brain Res, 185: 237-47.
  • FALGAIROLLE, M. and CAZALETS, J.R., (2007), Metachronal coupling between spinal neuronal networks during locomotor activity in newborn rat. J Physiol, 580: 87-102.

Grants:

  • Région Aquitaine Research Program (2008-2013)
  • Research Program Institut Recherche sur les Paraplégies, Genève (postdoctoral position, 2009-2010)
  • Fondation pour la Recherche Médicale «Interface Cerveau Machine ; 2011-2012

Publications 2006-2011:

  • Bestaven E, Guillaud E, Cazalets J-R (2012) Is “circling” behavior in humans related to postural asymmetry? PLoS ONE 7(9): e43861.
  • BERTRAND, S.S., and CAZALETS, JR. Cholinergic partition cells and lamina X neurons induce a muscarinic-dependent short-term potentiation of commissural glutamatergic inputs in lumbar motoneurons. soumis.
  • FALGAIROLLE, M., CECCATO, J.C., HERBIN, M., and CAZALETS, J.R (2011) Metachronal propagation of motor activity, sous presse, Encyclopedia of Bioscience
  • Amestoy A, Bouvard MP and Cazalets JR (2010). Left-right facial orientation of familiar faces: developmental aspects of « the mere exposure hypothesis ». Front. Psychology doi:10.3389/fpsyg.2010.00039
  • TARTAS, M., MORIN, F., BARRIERE, G., GOILLANDEAU, M., LACAILLE, J.C., CAZALETS, J.R., and BERTRAND, S.S., (2010), Noradrenergic modulation of intrinsic and synaptic properties of lumbar motoneurons in the neonatal rat spinal cord. Front Neural Circuits, 4: 4.
  • FOSSAT, P., DOBREMEZ, E., BOUALI-BENAZZOUZ, R., FAVEREAUX, A., BERTRAND, S.S., KILK, K., LEGER, C., CAZALETS, J.R., LANGEL, U., LANDRY, M., and NAGY, F., (2010), Knockdown of L calcium channel subtypes: differential effects in neuropathic pain. J Neurosci, 30: 1073-85.
  • DEMANY, L., SEMAL, C., CAZALETS, J.R., and PRESSNITZER, D., (2010), Fundamental differences in change detection between vision and audition. Exp Brain Res, 203: 261-70.
  • CECCATO, J.C., DE SEZE, M., AZEVEDO, C., and CAZALETS, J.R., (2009), Comparison of trunk activity during gait initiation and walking in humans. PLoS One, 4: e8193.
  • CECCATO, J.C., AZEVEDO-COSTE, C., and CAZALETS, J.R., (2009), Real time control of a CPG-based model of the human trunk in different walking conditions. Conf Proc IEEE Eng Med Biol Soc, 2009: 1388-91.
  • DE SEZE, M.P. and CAZALETS, J.R., (2008), Anatomical optimization of skin electrode placement to record electromyographic activity of erector spinae muscles. Surg Radiol Anat, 30: 137-43.
  • DE SEZE, M., FALGAIROLLE, M., VIEL, S., ASSAIANTE, C., and CAZALETS, J.R., (2008), Sequential activation of axial muscles during different forms of rhythmic behavior in man. Exp Brain Res, 185: 237-47.
  • BARRIERE, G., TARTAS, M., CAZALETS, J.R., and BERTRAND, S.S., (2008), Interplay between neuromodulator-induced switching of short-term plasticity at sensorimotor synapses in the neonatal rat spinal cord. J Physiol, 586: 1903-20.
  • FALGAIROLLE, M. and CAZALETS, J.R., (2007), Metachronal coupling between spinal neuronal networks during locomotor activity in newborn rat. J Physiol, 580: 87-102.
  • FALGAIROLLE, M., DE SEZE, M., JUVIN, L., MORIN, D., and CAZALETS, J.R., (2006), Coordinated network functioning in the spinal cord: an evolutionary perspective. J Physiol Paris, 100: 304-16.