Institut de Neurosciences Cognitives et Intégratives d'Aquitaine (UMR5287)

Aquitaine Institute for Cognitive and Integrative Neuroscience



INCIA - UMR 5287- CNRS
Université de Bordeaux

Zone nord Bat 2 2ème étage
146, rue Léo Saignat
33076 Bordeaux cedex
France

Téléphone 05.57.57.15.51
Télécopie 05.56.90.14.21

Supervisory authorities

CNRS Ecole Pratique des Hautes Etudes Université de Bordeaux

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Neurocampus Unitéde Formation de Biologie

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Garret Maurice

by Loïc Grattier - published on , updated on

Research Director, CNRS, University Bordeaux

Contact:
Maurice.garret@u-bordeaux2.fr
+33 (0)5 57 57 16 86

Site : Carreire

Team:
Neurobiology of behavior

Domain:
Neurotransmission / Synapses / receptor structure and functions/traficking

Research axis:

  • Physiology of GABAergic synapses-trafficking of GABAA receptors.
  • Cellular and molecular analysis of neurotransmission in neurological disorders: Amyotrophic Lateral sclerosis, Parkinson’s disease, etc…

Scientific expertise:

  • Molecular and cellular analysis of receptor physiology
  • GABAergic neurotransmission
  • Analysis of gene expression: Immunohistochemistry, Immunocytovhemistry, In Situ Hybridization, etc…
  • Molecular Biology-In vitro expression of recombinant proteins.

Projects:

  • One project aims at studying the link between activation and trafficking of GABAA receptors.
  • A research project aims at studying expression of receptors in the brain of wild-type and mutant mice (model of Hungtinton’disease).
  • Another project aims at analyzing receptor expression in spinal motoneurons of wild-type and mutant mice (model of Amyotrophic Lateral sclerosis).

Collaborations:

  • Dr J. Baufreton, IMN, University Bordeaux, France (GABAergic neurotransmission in the globus pallidus)

Selected Publications:

  • Belujon P, Baufreton J, Grandoso L, Boue-Grabot E, Batten TF, Ugedo L, Garret M, Taupignon AI (2009) Inhibitory transmission in locus coeruleus neurons expressing GABAA receptor epsilon subunit has a number of unique properties. J Neurophysiol 102:2312-2325.
  • Frugier G, Coussen F, Giraud MF, Odessa MF, Emerit MB, Boue-Grabot E, Garret M (2007) A gamma 2(R43Q) mutation, linked to epilepsy in humans, alters GABAA receptor assembly and modifies subunit composition on the cell surface. J Biol Chem 282:3819-3828.
  • Baufreton J, Zhu ZT, Garret M, Bioulac B, Johnson SW, Taupignon AI (2005) Dopamine receptors set the pattern of activity generated in subthalamic neurons. FASEB J 19:1771-1777.
  • Boue-Grabot E, Toulme E, Emerit MB, Garret M (2004a) Subunit-specific coupling between gamma-aminobutyric acid type A and P2X2 receptor channels. J Biol Chem 279:52517-52525.
  • Boue-Grabot E, Emerit MB, Toulme E, Seguela P, Garret M (2004b) Cross-talk and co-trafficking between rho1/GABA receptors and ATP-gated channels. J Biol Chem 279:6967-6975.
  • Milligan CJ, Buckley NJ, Garret M, Deuchars J, Deuchars SA (2004) Evidence for inhibition mediated by coassembly of GABAA and GABAC receptor subunits in native central neurons. J Neurosci 24:7241-7250.
  • Baufreton J, Garret M, Rivera A, de la Calle A, Gonon F, Dufy B, Bioulac B, Taupignon A (2003) D5 (not D1) dopamine receptors potentiate burst-firing in neurons of the subthalamic nucleus by modulating an L-type calcium conductance. J Neurosci 23:816-825.
  • Boue-Grabot E, Taupignon A, Tramu G, Garret M (2000) Molecular and electrophysiological evidence for a GABAc receptor in thyrotropin-secreting cells. Endocrinology 141:1627-1632.
  • Moragues N, Ciofi P, Lafon P, Odessa MF, Tramu G, Garret M (2000) cDNA cloning and expression of a gamma-aminobutyric acid A receptor epsilon-subunit in rat brain. Eur J Neurosci 12:4318-4330.

Grants:

  • Fondation de France, program ‘Physiologie et physiopathologie de la maladie de Parkinson’ (2006-07)
  • Communauté de Travail des Pyrénées, project ‘Synapse: from physiology to brain pathologies’ (2009-09)
  • Fondation pour la Recherche sur le Cerveau « étude de la mutation γ2(R43Q) (2007-09)
  • European Marie Curie Actions-International Research and training program ‘Synapses:from molecules to Brain and deseases” (2010-13)

Publications 2006-2011:

  • Jo YH, Donier E, Martinez A, Garret M, Toulmé E, Boué-Grabot E. Cross-talk between P2X4 and gamma-Aminobutyric Acid, Type A Receptors Determines Synaptic Efficacy at a Central Synapse. J Biol Chem. 2011 Jun 3;286(22):19993-20004. Epub 2011 Apr 11.
  • Pape JR, Bertrand SS, Lafon P, Odessa MF, Chaigniau M, Stiles JK, Garret M (2009) Expression of GABA(A) receptor alpha3-, theta-, and epsilon-subunit mRNAs during rat CNS development and immunolocalization of the epsilon subunit in developing postnatal spinal cord. Neuroscience 160:85-96.
  • Belujon P, Baufreton J, Grandoso L, Boue-Grabot E, Batten TF, Ugedo L, Garret M, Taupignon AI (2009) Inhibitory transmission in locus coeruleus neurons expressing GABAA receptor epsilon subunit has a number of unique properties. J Neurophysiol 102:2312-2325.
  • Ciofi P, Garret M, Lapirot O, Lafon P, Loyens A, Prevot V, Levine JE (2009) Brain-endocrine interactions: a microvascular route in the mediobasal hypothalamus. Endocrinology 150:5509-5519.
  • Frugier G, Coussen F, Giraud MF, Odessa MF, Emerit MB, Boue-Grabot E, Garret M (2007) A gamma 2(R43Q) mutation, linked to epilepsy in humans, alters GABAA receptor assembly and modifies subunit composition on the cell surface. J Biol Chem 282:3819-3828.
  • Toulme E, Blais D, Leger C, Landry M, Garret M, Seguela P, Boue-Grabot E (2007) An intracellular motif of P2X(3) receptors is required for functional cross-talk with GABA(A) receptors in nociceptive DRG neurons. J Neurochem 102:1357-1368.
  • Meissner W, Guigoni C, Cirilli L, Garret M, Bioulac BH, Gross CE, Bezard E, Benazzouz A (2007) Impact of chronic subthalamic high-frequency stimulation on metabolic basal ganglia activity: a 2-deoxyglucose uptake and cytochrome oxidase mRNA study in a macaque model of Parkinson’s disease. Eur J Neurosci 25:1492-1500.
  • Toulme E, Soto F, Garret M, Boue-Grabot E (2006) Functional properties of internalization-deficient P2X4 receptors reveal a novel mechanism of ligand-gated channel facilitation by ivermectin. Mol Pharmacol 69:576-587.