Institut de Neurosciences Cognitives et Intégratives d'Aquitaine (UMR5287)

Aquitaine Institute for Cognitive and Integrative Neuroscience



INCIA - UMR 5287- CNRS
Université de Bordeaux

Zone nord Bat 2 2ème étage
146, rue Léo Saignat
33076 Bordeaux cedex
France

Téléphone 05.57.57.15.51
Télécopie 05.56.90.14.21

Supervisory authorities

CNRS Ecole Pratique des Hautes Etudes Université de Bordeaux

Our partners

Neurocampus Unitéde Formation de Biologie

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Barriere Grégory

by Loïc Grattier - published on , updated on


CNRS, University of Bordeaux

Contact:
gregory.barriere@u-bordeaux.fr
+33 (0)5 57 57 95 43

Site : Carreire

Team:
Coordinations and Plasticities of Spinal Generators

Domain:
Motor Systems / Sensorimotor Integration /Spinal Cord Networks

Research axis:

  • Mammalian locomotion: role of the spinal cord circuitry
  • Locomotor and postural spinal cord networks interactions
  • Recovery of locomotion following spinal cord injury
  • Plasticity an metaplasticity of sensorimotor networks

Scientific expertise:

  • Spinal locomotor networks
  • In vitro isolated neonatal rodent brainstem-spinal cord preparations
  • Intra- and extracellular electrophysiology, neuropharmacology
  • Spinal cord injury, Treadmill locomotion

Projects:

  • Descending steering of the spinal locomotor networks.
  • DOPAergic modulation of spinal sensorimotor networks.
  • Neurochemistry of air-stepping following neonatal spinal cord lesions.
  • Remote CNS alteration after localized spinal or brain traumatic injuries.

Selected Publications:

  • Oueghlani Z, Simonnet C, Cardoit L, Courtand G, Cazalets JR, Morin D, Juvin L, Barrière G. Brainstem steering of locomotor activity in the newborn rat. J Neurosci. 2018 Jul 23. pii: 1074-18. doi: 10.1523
  • Barrière G, Leblond H, Provencher J, Rossignol S. Prominent role of the spinal central pattern generator in the recovery of locomotion after partial spinal cod injuries. J. Neurosci. 2008, 28 (15): 3976-87
  • Barrière G, Tartas M, Cazalets JR, Betrand SS. Interplay between neuromodulator-induced switching of short-term plasticity at sensorimotor synapses in the neonatal rat spinal cord. J. Physiol. 2008, 586 (7): 1903-20.
  • Barrière G, Mellen N, Cazalets JR. Neuromodulation of the locomotor network by dopamine in the isolated spinal cord of newborn rat. Eur J Neurosci. 2004, 19(5): 1325-1335.

Grants:

  • Université Bordeaux 2 (Preciput, 2010)

Publications

  • Oueghlani Z, Simonnet C, Cardoit L, Courtand G, Cazalets JR, Morin D, Juvin L, Barrière G. Brainstem steering of locomotor activity in the newborn rat. J Neurosci. 2018 Jul 23. pii: 1074-18. doi: 10.1523
  • Rodriguez-Grande B, Obenaus A, Ichkova A, Aussudre J, Bessy T, Barse E, Hibab B, Catheline G, Barrière G, Badaut J. Gliovascular changes precede white matter damage and long-term disorders in juvenile mild closed head injury. Glia. 2018.
  • Hirt L, Price M, Mastour N, Brunet JF, Barrière G, Friscourt F, Badaut J. Increase of aquaporin 9 expression in astrocytes participates in astrogliosis. J Neurosci Res. 2017 Apr 17. doi: 10.1002/jnr.24061.
  • Milan L, Courtand G, Cardoit L, Masmejean F, Barrière G, Cazalets JR, Bertrand SS. Age-related changes in pre- and postsynaptic partners of the cholinergic C-boutons in wild-type and SOD1G93A lumbar motoneurons. Plos one. 2015 Aug 25; 10 (8): e0135525.
  • Beliez L, Barrière G, Bertrand SS, Cazalets JR. Origin of thoracic spinal network activity during locomotor-like activity in the neonatal rat. J. Neurosci. 2015 Apr 15; 35 (15): 6117-30.
  • Beliez L, Barrière G, Bertrand SS, Cazalets JR. Multiple monoaminergic modulation of posturo-locomotor network activity in the newborn rat spinal cord. Front Neural Circuits. 2014 Aug 15; 8:99.
  • Milan L, Barrière G, De Deurwaerdère P, Cazalets JR, Bertrand SS..Monoaminergic control of spinal locomotor networks in SOD1G93A newborn mice. Front Neural Circuits. 2014 Jul 4; 8:77.
  • Rossignol S, Frigon A, Barrière G, Martinez M, Barthélemy D, Bouyer L, Bélanger M, Provencher J, Chau C, Brustein E, Barbeau H, Giroux N, Marcoux J, Langlet C, Alluin O. Spinal plasticity in the recovery of locomotion. Prog. Brain Res. 2011, 188: 229-41.
  • Barraud Q, Obeid I, Aubert I, Barrière G, Contamin H, McGuire S, Ravenscroft P, Porras G, Tison F, Bezard E, Ghorayeb I. Neuroanatomical study of the A11 diencephalospinal pathway in the non-human primate. Plos One, 2010, 5(10): e13306.
  • Barrière G, Frigon A, Leblond H, Provencher J, Rossignol S. Dual spinal lesion paradigm in the cat: evolution of the kinematic locomotor pattern. J. Neurophysiol., 2010, 104 (2): 1119-33
  • Tartas M, Morin F, Barrière G, Goillandeau M, Lacaille JC, Cazalets JR, Bertrand SS. Noradrenergic modulation of intrinsic and synaptic properties of lumbar motoneurons in the neonatal rat spinal cord. Front. Neural Circuits, 2010, 4: 4.
  • Frigon A*, Barrière G*, Leblond H, Rossignol S. Asymmetric changes in cutaneous reflexes after a partial spinal lesion and retention following spinalization during locomotion in the cat. J. Neurophysiol. 2009, 102 (5): 2667-80. (* co-first autors)
  • Rossignol S, Barrière G, Alluin O, Frigon A. Re-expression of locomotor function after partial spinal cord injury. Physiology, 2009, 24: 127-139.
  • Cohen-Adad J, Benali H, Barrière G, Leblond H, Hoge RD, Rossignol S. Development of clinical diffusion tensor MRI of the spinal cord in a context of spinal cord injury. IRBM, 2008, 29: 255-260.
  • Barrière G, Simmers J, Combes D. Multiple mechanisms for integrating proprioceptive inputs that converge on the same motor pattern-generating network. J. Neurosci. 2008, 28 (35) : 8810-20.
  • Barrière G, Leblond H, Provencher J, Rossignol S. Prominent role of the spinal central pattern generator in the recovery of locomotion after partial spinal cod injuries. J. Neurosci. 2008, 28 (15): 3976-87
  • Barrière G, Tartas M, Cazalets JR, Betrand SS. Interplay between neuromodulator-induced switching of short-term plasticity at sensorimotor synapses in the neonatal rat spinal cord. J. Physiol. 2008, 586 (7): 1903-20.
  • Frigon A, Yakovenko S, Gritsenko V, Tremblay ME, Barrière G. Strengthening corticospinal connections with chronic electrical stimulation after injury. J. Neurosci. (journal club) 2008, 28 (13): 3262-3.
  • Rossignol S, Barrière G, Frigon A, Barthélemy D, Bouyer L, Provencher J, Leblond H, Bernard G. Plasticity of locomotor sensorimotor interactions after peripheral and/or spinal lesions. Brain Res Rev. 2008, 57 (1): 228-240.
  • Frigon A, Barrière G, Fénélon K, Yakovenko S. Conceptualizing the mammalian locomotor central pattern generator with modelling. J. Physiol. (journal club) 2007, 580 (2): 363-4.
  • Barrière G, Cazalets JR, Bioulac B, Tison F, Ghorayeb I. The Restless Leg Syndrome. Prog Neurobiol. 2005, 77(3): 139-165.
  • Barrière G, Bertrand S, Cazalets JR. Peptidergic neuromodulation of the lumbar locomotor network in the neonatal rat spinal cord. Peptides. 2005, 26(2): 277-286.
  • Barrière G, Mellen N, Cazalets JR. Neuromodulation of the locomotor network by dopamine in the isolated spinal cord of newborn rat. Eur J.Neurosci. 2004, 19(5): 1325-1335.