Institut de Neurosciences Cognitives et Intégratives d'Aquitaine (UMR5287)

Aquitaine Institute for Cognitive and Integrative Neuroscience



INCIA - UMR 5287- CNRS
Université de Bordeaux

Zone nord Bat 2 2ème étage
146, rue Léo Saignat
33076 Bordeaux cedex
France

Téléphone 05.57.57.15.51
Télécopie 05.56.90.14.21

Supervisory authorities

CNRS Ecole Pratique des Hautes Etudes Université de Bordeaux

Our partners

Neurocampus Unitéde Formation de Biologie

GDR

GDR Robotique GDR Mémoire GDR Multi-électrodes

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Home > Teams > DSMN (P.BRANCHEREAU) > Projects

Early deficits in spinal motoneurons in ALS mouse models

by Branchereau Pascal - published on

ALS, also known as Lou Gehrig’s disease, is a fatal paralytic disease that results from the degeneration of upper descending cortical neurons and lower MNs located in the brainstem and spinal cord.

In this project, we make the hypothesis that ALS (familial and sporadic) relies on deficits occurring during embryonic development.

Our project proposes to 1) identify cellular mechanisms underlying the alteration of chloride homeostasis in prenatal (E17.5) spinal MNs, and 2) explore compensatory mechanisms allowing the occurrence of a normal locomotor activity.

This will be performed in the SOD1G93A mouse but also in another well-known ALS mouse model, the FUS knock-out mice (collaboration with Dr. Luc Dupuis - INSERM U1118, Univ. de Strasbourg).