Institut de Neurosciences Cognitives et Intégratives d'Aquitaine (UMR5287)

Aquitaine Institute for Cognitive and Integrative Neuroscience



INCIA - UMR 5287- CNRS
Université de Bordeaux

Zone nord Bat 2 2ème étage
146, rue Léo Saignat
33076 Bordeaux cedex
France

Téléphone 05.57.57.15.51
Télécopie 05.56.90.14.21

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CNRS Ecole Pratique des Hautes Etudes Université de Bordeaux

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Neurocampus Unitéde Formation de Biologie

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Home > Teams > Brain Molecular Imaging (J. BADAUT) > Research Interests

Preclinical work

by Lamare Frederic - published on , updated on

Traumatic Brain Injury (TBI)
Jerome Badaut: CNRS CR1, HDR
Beatriz Rodriguez-Grande: Post-doc fellow EraNet Neuron, CNSaflame
Aleksandra Ichkova: Graduate student, Labex-TRAIL-ANR
Justine Aussudre: Technician, AI University of Bordeaux

The neurovascular unit (NVU) is in part composed of cerebral blood vessels, neurons, and scattered in between them, an astrocyte sheath. The homeostasis of this unit is critical for normal brain function and activity, especially the maintenance of blood-brain barrier (BBB) properties that regulate entry of blood components and clearance of brain waste. The astrocyte network contributes to water and ion homeostasis, as well as brain energy metabolism.

Our research is focused on the changing physiological properties of the NVU after traumatic brain injury (TBI). TBI can occur at any point in a person’s lifetime, in particular the pediatric population, and is known to result in both short- and long-term consequences. The functional and molecular consequences after TBI might be a result of the changing NVU properties observed near the TBI injury site (with glial scar formation), at a distance from the site of the impact and at longterm after the injury. We are currently investigating the molecular mechanisms behind TBI-induced dysfunctions in NVU homeostasis (i.e. edema) using a rodent model. We evaluate these changes using magnetic resonance imaging (MRI), behavioral testing paradigms, and histological and molecular biology techniques to address specific protein targets at the NVU interface (for example: aquaporins in astrocytes, p-glycoproteins, caveolins…). We hope our understanding of these basic mechanisms will help to generate new biomarkers as well as target-specific drugs to promote functional recovery of individuals affected by brain injury.

Infection