Institut de Neurosciences Cognitives et Intégratives d'Aquitaine (UMR5287)

Aquitaine Institute for Cognitive and Integrative Neuroscience



INCIA - UMR 5287- CNRS
Université de Bordeaux

Zone nord Bat 2 2ème étage
146, rue Léo Saignat
33076 Bordeaux cedex
France

Téléphone 05.57.57.15.51
Télécopie 05.56.90.14.21

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CNRS Ecole Pratique des Hautes Etudes Université de Bordeaux

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Neurocampus Unitéde Formation de Biologie

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Home > Teams > PET Research (P. FERNANDEZ)

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Bordeaux PET Research center

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PET research unit

The PET research unit is a center dedicated to the molecular imaging with positron emitter tracers, created jointly in 2010 by the Hospital and the University of Bordeaux on the site of Xavier Arnozan hospital in Pessac. Since 2011, this unit is a core team of laboratory of excellence TRAIL.
The centre, under the responsibility of Professor Philippe Fernandez, hosts a team of a dozen people from different departments and conducts imaging research in the CNRS laboratory INCIA (UMR 5287) directed by Jean-René Cazalets.

Our expertise is triple

  • Participating to multicentric clinical trials promoted by academic structures (hospital, university) or industrial partners,
  • Developing and conducting clinical trials in oncology and neurology fields with commercial tracers or tracers without market authorization (in situ synthesis)
  • Developing and validating new radiopharmaceuticals (synthesis of specific peptides in collaboration with ISM-UMR 5255 directed by Dr Eric Fouquet, or aptamers in collaboration with ARNA laboratory-INSERM U869 directed by Dr Jean-Jacques Toulmé, development of new methods for fast synthesis of tracers radiolabeled with gallium 68).

For our research, the use, the development and synthesis of radiopharmaceuticals is possible through:

  • a laboratory of radiochemistry equipped with some hot cells shared with an industrial partner, IBA molecular-CisBio international, which develops new tracers for clinical use (Fcholine, for example). Various radiopharmaceuticals radiolabelled with 18-Fluorine are synthetized for clinical protocols (such as 18FDG, 18FMISO, 18FLT, 18MPPF, 18FEOBV, 18PBR06,….), but also, new tracers are under development for preclinical validation (tracer for angiogenesis imaging, extracellular matrix targeting, tracers for multimodal (PET-MR) imaging...).
  • a hot cell localized in PET unit equipped with a synthetizer (FastLab) in collaboration with an industrial partner (GE healthcare).This synthetizer permits the synthesis of new tracers radiolabelled with gallium 68 (somatostatin receptors, GRP receptors, PSMA…). Finally, the laboratory is equipped with an HPLC and a UV detector intended in the quality control of new synthesized radiopharmaceuticals.
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GE Discovery RX PET/CT system

The clinical exams are realized on a PET-CT machine (GE Discovery RX) since May 2010 (agreement number: 333180116LBD012010). This machine is under responsability of the biomedical imaging unit (UMS3767) directed by Mr Sylvain Miraux.
Since five years, the research molecular imaging unit has obtained the European PET/CT accreditation by the European Association of Nuclear Medicine (EANM) giving to our centre a label of excellence in PET imaging research field.
Then, our team develops also methodologies in image processing concerning segmentation methods for radiotherapy planning treatment, pharmacokinetics modelling or imaging correction methods.

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Exemple of F-Choline PET image for prostate cancer

The interest of our center is to propose a PET-CT machine entirely dedicated to research which offers ability to realize dynamic and long time acquisitions for example study of tumoral hypoxia during 4 hours, but also flexibility in scan scheduling compared to a PET-CT used for routine activity.

Industrial collaborations for clinical trials to obtain AMM for fluorocholine (IBA Molecular) and to study relationships between the amyloid load and cognitive performance with a PET Flutemetamol imaging (GE Healthcare).

So, our PET centre proposes a translational research from development and validation of new PET tracers to clinical trials in different fields such as oncology, neurology but also infection and inflammation diseases.

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Exemple of an AV45 PET image