Institut de Neurosciences Cognitives et Intégratives d'Aquitaine (UMR5287)

Aquitaine Institute for Cognitive and Integrative Neuroscience



INCIA - UMR 5287- CNRS
Université de Bordeaux

Zone nord Bat 2 2ème étage
146, rue Léo Saignat
33076 Bordeaux cedex
France

Téléphone 05.57.57.15.51
Télécopie 05.56.90.14.21

Supervisory authorities

CNRS Ecole Pratique des Hautes Etudes Université de Bordeaux

Our partners

Neurocampus Unitéde Formation de Biologie

GDR

GDR Robotique GDR Mémoire GDR Multi-électrodes

Search




Home > Directory

David Vincent

by Loïc Grattier - published on , updated on

Chargé de Recherches CNRS (CR1)
HDR (Habilitation à diriger une thèse)

Contact:
vincent.david@u-bordeaux.fr

05 40 00 33 59

Site : Talence

Team: Memory Interacting Networks, Drugs and Stress (M.I.N.D.S)

Domain: Cognitive / Behavioral Neuroscience / Neuropharmacology

Research axis:
1. Memory systems of the addicted brain
2. Positive reinforcing properties of abused drugs: molecular substrates

Scientific expertise:

  • Integrated study of animal behaviour
  • Mouse models of drug self-administration
  • Behavioral phenotyping of genetically-engineered mouse strains
  • Functional cellular imaging (immunostaining)
  • Mouse stereotaxic microsurgery

Projects:

  • Role of nicotinic receptor subtypes in nicotine’s addictive and cognitive effects

Collaborations:

  • Jean-Pierre Changeux, Collège de France, Paris
  • Stephanie Cragg, Dept of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
  • Richard Exley, Dept of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
  • Philippe Faure, Neuroscience Paris-Seine, Université Pierre et Marie Curie, Paris
  • Sylvie Granon, Neurobiologie de l’Apprentissage, de la Mémoire et de la Communication, Orsay
  • Brigitte Kieffer, Dpt de Neurobiologie, Institut de Génétique et Biologie Moléculaire, Illkirch
  • George F. Koob, Committee on Addictive disorders, La Jolla, CA, USA
  • Uwe Maskos, Neurobiologie Intégrée des Systèmes Cholinergiques, Institut Pasteur, Paris
  • Mark E. Walton, Oxford University

Grants:

  • NIDA (1997-2001)
  • IREB (2002-2005)
  • MRT (2006-2008)
  • CNRS / Région Aquitaine (2008-2011)
  • FRC Neurodon (2013)
  • ANR programme Blanc (2011-2014)
  • LabEx (2014-2015)

Selected publications:

- Dominguez G, Belzung C, David V, Piérard C, Henkous N, Decorte L, Mons N, Béracochéa D. (2015) Long-lasting elevation of corticosterone levels in the prefrontal cortex of alcohol withdrawn mice are responsible for reduction of CREB phosphorylation and working memory decrement. Addic Biol, in press

- Tolu S, Eddine, David V, Graupner M, Pons S, Baudonnat M, Husson M, Besson M, Reperant C, Zemdegs J, Pagès C, Hay Y, Lambolez B, Caboche J, Gutkin B, Gardier AM, Changeux JP, Faure P, Maskos U (2013) Co-activation of VTA DA and GABA neurons mediates nicotine reinforcement. Mol Psychiatry 18, 382-393.

- Baudonnat M, Guillou JL, Husson M, Vandesquille M, Corio M, Decorte L, Faugère A, Porte Y, Mons N, David V. (2012) Disrupting effect of drug-induced reward on spatial but not cue-guided learning: implication of the striatal protein kinase A/cAMP response element-binding protein pathway. J Neurosci. 31(46): 16517-16528.

- Exley R, Maubourguet N, David V, Eddine R, Evrard A, Pons S, Marti F, Threlfell S, Cazala P, McIntosh JM, Changeux JP, Maskos U, Cragg SJ, Faure P (2011) Distinct contributions of nicotinic acetylcholine receptor subunit alpha4 and subunit alpha6 to the reinforcing effects of nicotine. Proc Natl Acad Sci U S A 108:7577-7582.

- Besson M, Granon S, Mameli-Engvall M, Cloez-Tayarani I, Maubourguet N, Cormier A, Cazala P, David V, Changeux JP, Faure P (2007) Long-term effects of chronic nicotine exposure on brain nicotinic receptors. Proc Natl Acad Sci U S A 104:8155-8160.

- Maskos U, Molles BE, Pons S, Besson M, Guiard BP, Guilloux JP, Evrard A, Cazala P, Cormier A, Mameli-Engvall M, Dufour N, Cloez-Tayarani I, Bemelmans AP, Mallet J, Gardier AM, David V, Faure P, Granon S, Changeux JP (2005) Nicotine reinforcement and cognition restored by targeted expression of nicotinic receptors. Nature 436:103-107.