Institut de Neurosciences Cognitives et Intégratives d'Aquitaine (UMR5287)

Aquitaine Institute for Cognitive and Integrative Neuroscience



INCIA - UMR 5287- CNRS
Université de Bordeaux

Zone nord Bat 2 2ème étage
146, rue Léo Saignat
33076 Bordeaux cedex
France

Téléphone 05.57.57.15.51
Télécopie 05.56.90.14.21

Supervisory authorities

CNRS Ecole Pratique des Hautes Etudes Université de Bordeaux

Our partners

Neurocampus Unitéde Formation de Biologie

GDR

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David Vincent

by Loïc Grattier - published on , updated on

Chargé de Recherches CNRS (CR1)
HDR (Habilitation à diriger une thèse)

Contact:
vincent.david@u-bordeaux.fr

05 40 00 33 59

Site : Talence

Team: Memory Interacting Networks, Drugs and Stress (M.I.N.D.S)

Domain: Cognitive / Behavioral Neuroscience / Neuropharmacology

Research axis

1. Reward and positive reinforcing properties of drugs of abuse
2. Memory systems in normal and addicted brains

Scientific expertise

  • Integrated study of animal behaviour: addiction and memory
  • Mouse models of drug self-administration
  • Phenotyping of genetically-engineered mouse strains
  • Functional cellular imaging (immunostaining)
  • Mouse stereotaxic microsurgery

Projects

  • Role of nicotinic receptor subtypes in nicotine addiction
  • Alterations of memory systems in addictive behaviors
  • Mouse models of alcohol abuse

Collaborations

  • Jean-Pierre Changeux, Collège de France, Paris
  • Stephanie Cragg, Dept of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
  • Richard Exley, Dept of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
  • Philippe Faure, Neuroscience Paris-Seine, Université Pierre et Marie Curie, Paris
  • Sylvie Granon, Neurobiologie de l’Apprentissage, de la Mémoire et de la Communication, Orsay
  • George F. Koob, Committee on Addictive disorders, La Jolla, CA, USA
  • Uwe Maskos, Neurobiologie Intégrée des Systèmes Cholinergiques, Institut Pasteur, Paris
  • Mark E. Walton, Dept of Experiment Psychology, University of Oxford
  • Veronique D. Bohbot, Douglas Institute, University of Montreal
  • Lars Schwabe, Dept of Cognitive Psychology, University of Hambourg

Grants

  • NIDA (1997-2001)
  • IREB (2002-2005)
  • MRT (2006-2008)
  • CNRS / Région Aquitaine (2008-2011)
  • FRC Neurodon (2013)
  • ANR programme Blanc (2011-2015)
  • LabEx (2016-2019)
  • ANR/INCa (2017-2020)

Selected publications

Husson M, Harrington L, Tochon L, Cho I, Ibanes-tallon I, Maskos U, David V (2020) β4-Nicotinic Receptors Are Critically Involved in Reward-Related Behaviors and Self-Regulation of Nicotine Reinforcement. Journal of Neuroscience 40 (17) 3465-3477.

Béracochéa D, Mons N, David V (2019). Targeting the glucocorticoid receptors during alcohol-withdrawal to reduce protracted neurocognitive disorders. Front Psychiatry. 2019 Sep 18;10:580. doi: 10.3389/fpsyt.2019.00580. eCollection 2019. Review

Baudonnat M, Guillou JL, Husson M, Bohbot VD, Schwabe L, David V (2017) Morphine Reward Promotes Cue-Sensitive Learning: Implication of Dorsal Striatal CREB Activity. Front Psychiatry 8:87. eCollection 2017.

Dominguez G, Belzung C, Pierard C, David V, Henkous N, Decorte L, Mons N, Béracochéa D (2016) Alcohol withdrawal induces long-lasting spatial working memory impairments: relationship with changes in corticosterone response in the prefrontal cortex. Addict Biol 22(4):898-910. Epub 2016 Feb 10.

Tolu S, Eddine, David V, Graupner M, Pons S, Baudonnat M, Husson M, Besson M, Reperant C, Zemdegs J, Pagès C, Hay Y, Lambolez B, Caboche J, Gutkin B, Gardier AM, Changeux JP, Faure P, Maskos U (2013) Co-activation of VTA DA and GABA neurons mediates nicotine reinforcement. Mol Psychiatry 18, 382-393.

Baudonnat M, Guillou JL, Husson M, Vandesquille M, Corio M, Decorte L, Faugère A, Porte Y, Mons N, David V. (2012) Disrupting effect of drug-induced reward on spatial but not cue-guided learning: implication of the striatal protein kinase A/cAMP response element-binding protein pathway. J Neurosci. 31(46): 16517-16528.

Exley R, Maubourguet N, David V, Eddine R, Evrard A, Pons S, Marti F, Threlfell S, Cazala P, McIntosh JM, Changeux JP, Maskos U, Cragg SJ, Faure P (2011) Distinct contributions of nicotinic acetylcholine receptor subunit alpha4 and subunit alpha6 to the reinforcing effects of nicotine. Proc Natl Acad Sci U S A 108:7577-7582.

Besson M, Granon S, Mameli-Engvall M, Cloez-Tayarani I, Maubourguet N, Cormier A, Cazala P, David V, Changeux JP, Faure P (2007) Long-term effects of chronic nicotine exposure on brain nicotinic receptors. Proc Natl Acad Sci U S A 104:8155-8160.

Maskos U, Molles BE, Pons S, Besson M, Guiard BP, Guilloux JP, Evrard A, Cazala P, Cormier A, Mameli-Engvall M, Dufour N, Cloez-Tayarani I, Bemelmans AP, Mallet J, Gardier AM, David V, Faure P, Granon S, Changeux JP (2005) Nicotine reinforcement and cognition restored by targeted expression of nicotinic receptors. Nature 436:103-107.