Institut de Neurosciences Cognitives et Intégratives d'Aquitaine (UMR5287)

Aquitaine Institute for Cognitive and Integrative Neuroscience



INCIA - UMR 5287- CNRS
Université de Bordeaux

Zone nord Bat 2 2ème étage
146, rue Léo Saignat
33076 Bordeaux cedex
France

Téléphone 05.57.57.15.51
Télécopie 05.56.90.14.21

Supervisory authorities

CNRS Ecole Pratique des Hautes Etudes Université de Bordeaux

Our partners

Neurocampus Unitéde Formation de Biologie

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Beracochea Daniel

by Loïc Grattier - published on , updated on

Directeur de Recherches CNRS (DR2), HDR

Contact:
daniel.beracochea@u-bordeaux.fr
+33 (0)5 40 00 24 39

Site : Talence

Team:
Decision and Adaptation

Domain:
Cognition and behaviour / Animal cognition and behaviour/ Pharmacology

Research axis:

  • Memory processes and HPA axis dysfunction
  • Impact of alcohol withdrawal and stress on emotion and memory

Scientific expertise:

  • Integrated study of animal behaviour
  • Specific stereotaxy (excitotoxic lesion / cannulae implantation)
  • Microdialysis
  • Pharmacology

Projects:

  • Determining how stress or chronic alcohol withdrawal affect cognitive and emotional processes in relation with regional brain glucocorticoids dysfunction.

Collaborations:

  • Dr Christophe PIERARD Institut de recherches biomédicales des armées, 91223 Brétigny sur Orge
  • Dr Catherine BELZUNG Université François Rabelais, Inserm U1253, 37200 Tours

Selected Publications:

  • Rabat Y, Henkous N, Corio M, Nogues X, Beracochea D. Baclofen but Not Diazepam Alleviates Alcohol-Seeking Behavior and Hypothalamic-Pituitary-Adrenal Axis Dysfunction in Stressed Withdrawn Mice. Front Psychiatry. 2019 Apr 16;10:238. doi: 10.3389/fpsyt.2019.00238. eCollection 2019. PMID: 31105600 Free PMC article.
  • Dominguez G, Henkous N, Prevot T, David V, Guillou JL, Belzung C, Mons N, Béracochea D. Sustained corticosterone rise in the prefrontal cortex is a key factor for chronic stress-induced working memory deficits in mice. Neurobiol Stress. 2019 Apr 4;10:100161. doi: 10.1016/j.ynstr.2019.100161. eCollection 2019 Feb.
  • Beracochea D, Mons N, David V. Front Psychiatry. 2019 Sep 18;10:580. doi: Targeting the Glucocorticoid Receptors During Alcohol Withdrawal to Reduce Protracted Neurocognitive Disorders. Front Psychiatry. 2019 Sep 18;10:580. doi: 10.3389/fpsyt.2019.00580. eCollection 2019.
  • Pierard C, Dorey R, Henkous N, Mons N, Béracochea D.Different implications of the dorsal and ventral hippocampus on contextual memory retrieval after stress. Hippocampus. 2017 Sep;27(9):999-1015. doi: 10.1002/hipo.22748. Epub 2017 Jun 24.
  • Dominguez G, Belzung C, Pierard C, David V, Henkous N, Decorte L, Mons N, Beracochea D. Alcohol withdrawal induces long-lasting spatial working memory impairments: relationship with changes in corticosterone response in the prefrontal cortex. Addict Biol. 2017 Jul;22(4):898-910. doi: 10.1111/adb.12371. Epub 2016 Feb 10.

Grants:

  • SERVIER laboratories (IDRS et IRIS)
  • Institut de Recherche sur les Boissons (IREB)
  • Naturex

Publications 2015-2021:

- Rabat Y, Henkous N, Corio M, Nogues X, Beracochea D. Baclofen but Not Diazepam Alleviates Alcoholn Seeking Behavior and Hypothalamic-Pituitary-Adrenal Axis Dysfunction in Stressed Withdrawn Mice. Front Psychiatry. 2019 Apr 16; 10: 238. doi: 10.3389/fpsyt.2019.00238. eCollection 2019. PMID: 31105600 Free PMC article.

- Piérard C, Dorey R, Corio M, Béracochéa D. Lesion of the dorsal hippocampus alters the time-course evolution of corticosterone rise in the ventral hippocampus after stress. Neuroreport. 2019 Jul 3;30(10):707-712.

- Dominguez G, Henkous N, Prevot T, David V, Guillou JL, Belzung C, Mons N, Béracochéa D. Sustained corticosterone rise in the prefrontal cortex is a key factor for chronic stress-induced working memory deficits in mice. Neurobiol Stress. 2019 Apr 4;10: 100161. doi: 10.1016/j.ynstr.2019.100161. eCollection 2019 Feb. PMID: 31309134.

- Louis C, Llopis K, Danober L, Panayi F, Lestage P, Beracochea D. New procognitive enhancers acting at the histamine H3 and AMPA receptors reverse natural forgetting in mice: comparisons with donepezil and memantine in the object recognition task. Behav Pharmacol. 2019 Jun;30(4):351-357.

- Chauveau F, De Job E, Poly-Thomasson B, Cavroy R, Thomasson J, Fromage D, Beracochea D. Procognitive impact of ciproxifan (a histaminergic H3 receptor antagonist) on contextual memory retrieval after acute stress. CNS Neurosci Ther. 2019 Aug;25(8):832-841. doi: 10.1111/cns.13113. Epub 2019 May 15. PMID: 31094061

- Béracochéa D, Mons N, David V.Targeting the Glucocorticoid Receptors During Alcohol Withdrawal to Reduce Protracted Neurocognitive Disorders. Front Psychiatry. 2019 Sep 18; 10:580. doi: 10.3389/fpsyt.2019.00580. eCollection 2019. PMID: 31620025 Free PMC article. Review.

- David V, Béracochéa D, Walton ME. Editorial: Memory Systems of the Addicted Brain: The Underestimated Role of Cognitive Biases in Addiction and Its Treatment. Front Psychiatry. 2018 Feb 19;9: 30. doi: 10.3389/fpsyt.2018.00030

- Dominguez G, Henkous N, Pierard C, Belzung C, Mons N and Beracochea D Diazepam rescues working memory and glucocorticoids alterations in the prefrontal cortex after short but not long alcohol-withdrawal periods. Cognitive, Affective and Behavioral Neurosciences 2018 Aug;18(4):665-679

- Thomas Damien Prévôt, Gaelle Dominguez, Cécile Viollet, Jacques Epelbaum, Daniel Béracochéa and Jean-Louis Guillou The sst2 receptor deletion exacerbates unpredictable chronic mild stress-induced deficits during middle-age: consequences for emotional and cognitive aging. Progress in Biological Psychiatry and Neuropsychopharmacology 2018 Aug 30; 86:390-400. doi: 10.1016/j.pnpbp.2018.01.022.

- Bretin S, Krazem A, Henkous N, Froger-Colleaux C, Mocaer E, Louis C, Perdaems N, Marighetto A and Beracochea D. Synergistic enhancing-memory effect of donepezil and S 47445, an AMPA positive allosteric modulator, in middle-aged and aged mice. Psychopharmacology (Berl). 2018 Mar;235(3):771-787

- Dominguez G, Belzung C, Pierard C, David V, Henkous N, Decorte L, Mons N, Beracochea D. Alcohol withdrawal induces long-lasting spatial working memory impairments: relationship with changes in corticosterone response in the prefrontal cortex. Addict. Biol. 2017 Jul;22(4):898-910

- Pierard C, Dorey R, Henkous N, Mons N, Béracochéa D. Distinct implication of dorsal and ventral hippocampus in mediating the rapid effects of acute stress on memory retrieval. Hippocampus. 2017 Sep;27(9):999-1015

- Lemaire-Mayo V, Subashi E, Henkous N, Beracochea D and Pietropaolo S. Behavioral effects to adult chronic stress in the fmr1 mouse model for fragile x syndrome Behavioural Brain Research 2017 Mar 1;320:128-135

- Thomas D. Prévôt, François Gastambide, Cécile Viollet, Nadia Henkous, Guillaume Martel, Jacques Epelbaum, Daniel Béracochéa and Jean-Louis Guillou. Roles of hippocampal somatostatin receptor subtypes in stress response and emotionality. Neuropsychopharmacology, 2017 Jul;42(8):1647-1656.

- Bretin S, Louis C, Seguin L, Beracochea D, et al. Pharmacological characterisation of S 47445, a novel positive allosteric modulator of AMPA receptors Plos One, 2017 Sep 8;12(9):e0184429. doi: 10.1371/journal.pone.0184429.

- Fanny Gros-Désormeaux, Daniel Beracochea, Frédéric Dorandeu, Christophe Piérard. Cognitive and emotional impairments after cutaneous intoxication by CEES (a sulfur mustard analog) in mice. Toxicol Lett. 2017 Jul 22. pii: S0378-4274(17)31135-9

- Faucher P, Mons N, Micheau J, Louis C, Beracochea DJ. Hippocampal Injections of Oligomeric Amyloid β-peptide (1-42) Induce Selective Working Memory Deficits and Long-lasting Alterations of ERK Signaling Pathway. Front Aging Neurosci. 2016 11;7:245.

- Dominguez G, Dagnas M, Decorte L, Vandesquille M, Belzung C, Béracochéa D, Mons N. Rescuing prefrontal cAMP-CREB pathway reverses working memory deficits during withdrawal from prolonged alcohol exposure. Brain Struct Funct. 2016 Mar;221 (2):865-77

- Sors A, Krazem A, Kehr J, Yoshitake T, Dominguez G, Henkous N, Letondor C, Mocaer E and Beracochea D. The synergistic enhancing-memory effect of Donepezil and S 38093 (a histamine H3 antagonist) is mediated by increased neural activity in the septo-hippocampal circuitry in middle-aged mice. Frontiers in Pharmacology 2016 Dec 22; 7:492. doi: 10.3389/fphar.2016.0049.

- Beracochea D, Krazem A, Henkous N, HaccardG, Roller M, Fromentin E. Chronic intake of wild blueberry full spectrum powder outperforms wild blueberry extract for improving episodic-like and working memory during normal aging in mice Planta Medica 2016 Aug;82(13):1163-8. doi: 10.1055/s-0042-104419

- Mons N and Beracochea D. Behavioral neuroadaptation to alcohol: from glucocorticoids to histone acetylation. Frontiers in Psychiatry, 2016, 6;7:165.
Pierard C, Krazem A, Henkous N, Decorte L, Béracochéa D Acute stress blocks the caffeine-induced enhancement of contextual memory retrieval in mice.Eur J Pharmacol. 2015 Aug 15;761:70-8.

- Dagnas M, Micheau J, Decorte L, Beracochea D, Mons N.Post-training, intra-hippocampal HDAC inhibition differentially impacts neural circuits underlying spatial memory in adult and aged mice. Hippocampus. 2015 Jul;25(7):827-37

- L. Danober, C. Louis, N. Rogez, J.Y. Thomas, G. Das Dores, M.H. Gandon, A. Hugot, D. Beracochea, A. Krazem, V. Bertaina-AngladE, D. Rimet, T. Pillot, M. Bertrand J.M. Fourquez, I. Botez, P. Lestage (2015) Pharmacological profile of S 76892, a new ligand at nicotinic α7-subtype receptors Biochemical Pharmacology 97 (4) : 624–625