Institut de Neurosciences Cognitives et Intégratives d'Aquitaine (UMR5287)

Aquitaine Institute for Cognitive and Integrative Neuroscience



INCIA - UMR 5287- CNRS
Université de Bordeaux

Zone nord Bat 2 2ème étage
146, rue Léo Saignat
33076 Bordeaux cedex
France

Téléphone 05.57.57.15.51
Télécopie 05.56.90.14.21

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CNRS Ecole Pratique des Hautes Etudes Université de Bordeaux

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Neurocampus Unitéde Formation de Biologie

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Home > Teams > MINDS (D.BERACOCHEA / V. DAVID)

Research Interest

by Loïc Grattier - published on , updated on

The standard theory of mnesic consolidation posits that, to influence durably behavior, any given information needs to be not only detected but also processed at the cellular and circuits levels for several hours, days or weeks (even longer in humans). The theory however does not explain how is selected the information which has to be consolidated, and how is achieved the consolidation process. A corollary hypothesis is that once the information is “memorized”, it should be readily available for recall. However, memory retrieval is a process which is paradoxically very sensitive to disruption, induced for instance by stress or ageing.

Our general hypothesis is that the emotional charge of events is an essential determinant for both selecting the information that needs to be consolidated, and retrieving it on demand. Thus, the main goal of the team is to study how positive or negative emotions impact memory processes from learning to retrieval and how stress and aging modify the emotion-memory interactions in normal versus pathological states. Our project is more specifically based on three related questions:

(i) What are the immediate and delayed effects of positive and negative emotions on learning and memory processes and associated brain mechanisms in normal young adult mice?

(ii) Are these effects significantly altered by ageing or in pathological states (animal transgenic models of Alzheimer’s disease, chronic alcohol and diencephalic pathology)?

(iii) To what extent is emotional regulation of memory processes involved in these cognitive deficits and how is it possible to restore memory functions?