Institut de Neurosciences Cognitives et Intégratives d'Aquitaine (UMR5287)

Aquitaine Institute for Cognitive and Integrative Neuroscience



INCIA - UMR 5287- CNRS
Université de Bordeaux

Zone nord Bat 2 2ème étage
146, rue Léo Saignat
33076 Bordeaux cedex
France

Téléphone 05.57.57.15.51
Télécopie 05.56.90.14.21

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CNRS Ecole Pratique des Hautes Etudes Université de Bordeaux

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Neurocampus Unitéde Formation de Biologie

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STED imaging reveals activity-dependent plasticity of axon morphology linked to changes in action potential conduction velocity by Ronan Chereau, Ezequiel Saraceno, Julie Angibaud, Daniel Cattaert and U. Valentin Nägerl

by Loïc Grattier - published on

STED imaging reveals activity-dependent plasticity of axon morphology linked to changes in action potential conduction velocity by Ronan Chereau, Ezequiel Saraceno, Julie Angibaud, Daniel Cattaert and U. Valentin Nägerl

Publication date: January 23, 2017 in Proceedings of the National Academy of Sciences (PNAS)

Using time-lapse super-resolution microscopy in brain slices from hippocampus, this paper shows that axon diameters are dynamically regulated by activity-dependent mechanisms. Thereby, the conduction speed of action potentials in unmyelinated axons of hippocampus is also regulated. Simulations of action potential propagation incorporating these morphological dynamics predicted bi-directional effects on action potential conduction speed. The predictions were confirmed by electrophysiological experiments. Taken together, this study outlines a novel morphological plasticity mechanism for dynamically fine-tuning action potential conduction velocity, which potentially has wide implications for the temporal transfer of information in the brain.