Institut de Neurosciences Cognitives et Intégratives d'Aquitaine (UMR5287)

Aquitaine Institute for Cognitive and Integrative Neuroscience

Université de Bordeaux

Zone nord Bat 2 2ème étage
146, rue Léo Saignat
33076 Bordeaux cedex


Supervisory authorities

CNRS Ecole Pratique des Hautes Etudes Université de Bordeaux

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Neurocampus Unitéde Formation de Biologie


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Home > Teams > OASM (M. THOBY-BRISSON)


by Loïc Grattier - published on , updated on


  • Le Gal JP, Colnot E, Cardoit L, Bacqué Cazenave J, Thoby-Brisson M, Juvin L & Morin D (2020) Modulation of respiratory network activity by forelimb and hindlimb locomotor generators. Eur J Neurosci preprint at doi:10.1111/ejn.14717.
  • Bedecarrats A & Nargeot R (2020) Gastropod Learning and Memory (Aplysia, Lymnaea, Hermissenda, and Others). In: Oxford Research Encyclopedia of Neuroscience (Ed. M. Sherman. New York and Oxford: Oxford University Press, USA). (In press).
  • Olechowski-Bessaguet A, Grandemange R., Cardoit L., Courty E. , Lambert FM* & Le Ray D* (2020) Functional organization of vestibulospinal inputs on thoracic motoneurons responsible for trunk postural control in Xenopus. J Physiol 598.4, 817-838.


  • Nargeot R & Bedecarrats A (2019) Associative learning in invertebrates. In: Oxford Handbook of Invertebrate Neurobiology (Ed. J.H. Byrne. Oxford University Press, USA).
  • Nargeot R & Puygrenier L (2019) Operant learning in invertebrates. In: Reference Module in Life Science (ScienceDirect, Elsevier).


  • Bacqué-Cazenave J, Cattaert D, Delbecque JP & Fossat P (2018) Alteration of size perception: serotonin has opposite effects on the agressiveness of crafish confronting either a smaller or a larger rival. J Exp Biol 221, jeb177840. doi:10.1242/jeb.177840.
  • Bacqué-Cazenave J, Courtand G, Beraneck M, Lambert FM & Combes D (2018) Temporal relationship of ocular and tail segmental movements underlying locomotor-induced gaze stabilization during undulatory swimming in larval Xenopus. Front Neural Circuits 12, doi:10.3389/fncir.2018.00095. eCollection 2018.
  • Dubois CJ, Cardoit L, Schwartz V, Markkanen M, Airaksinen MS, Uvarov P, Simmers J & Thoby-Brisson M (2018) Role of the K+-Cl- cotransporter KCC2a isoform in mammalian respiration at birth. eNeuro 5, ENEURO.0264-18.2018. doi:10.1523/ENEURO.0264-18.2018.
  • Lambert FM, Cardoit L, Courty E, Bougerol M, Thoby-Brisson M, Simmers J, Tostivint H & Le Ray D (2018) Functional limb muscle innervation prior to cholinergic transmitter specification during early metamorphosis in Xenopus. eLife 7, e30693.
  • Nicolosi A, Cardoit L, Pasquereau P, Jaillet C, Thoby-Brisson M, Juvin L & Morin D (2018) Acute exposure to zinc oxide nanoparticules critically disrupts operation of the respiratory neural network in neonatal rat. Neurotoxicology 67, 150-160.
  • Straka H, Simmers J & Chagnaud BP (2018) A new perspective on predictive motor signaling. Curr Biol 28, R232-R243.
  • Svehla P, Bedecarrats A, Jahn C, Nargeot R & Ciobanu L (2018) Intracellular manganese-enhanced MRI signals reflect the frequency of action potentials in Aplysia neurons. J Neurosci Meth 295, 121-128.
  • Thoby-Brisson M (2018) Neural mechanisms for sigh generation during prenatal development. J Neurophysiol 120, 1162-1172.


  • Chevalier M, Cardoit L, Moreau M, Sans N, Montcouquiol M, Simmers J & Thoby-Brisson M (2017) The embryonic development of hindbrain respiratory networks is unaffected by mutation of the planar polarity protein Scribble. Neuroscience, 357, 160-171.
  • Nargeot R & Bedecarrats A (2017) Electrical synapses and learning-induced plasticity in motor rhythmogenesis. In: Nework functions and plasticity (Ed. J. Jing. Academic Press, UK).


  • Chevalier M, De Sa R, Cardoit L & Thoby-Brisson M (2016) Mechanisms underlying adaptation of respiratory network activity to modulatory stimuli in the mouse embryo. Neural Plast, 2016:3905257.
  • Chevalier M, Toporikova N, Simmers J & Thoby-Brisson M (2016) Development of pacemaker properties and rhythmogenic mechanisms in the mouse embryonic respiratoty network. eLife, 16125.
  • Currie SP, Combes D, Scott NW, Simmers J & Sillar KT (2016) A behaviorally-related developmental switch in nitrergic modulation of locomotor rhythmogenesis in larval Xenopus tadpoles. J Neurophysiol 115, 1446-1457.
  • Lambert FM, Bras H, Cardoit L, Vinay L, Coulon P & Glover JC (2016) Early postnatal maturation in vestibulospinal pathways involved in neck and forelimb motor control. Dev Neurobiol 76, 1061-1077.
  • von Uckermann G, Lambert FM, Combes D, Straka H & Simmers J (2016) Adaptive plasticity of spino-extraocular motor coupling during locomotion in metamorphosing Xenopus. J Exp Biol 219, 1110-1121.


  • Bougerol M, Auradé F, Lambert FM, Le Ray D, Combes D, Thoby-Brisson M, Relaix F, Pollet N & Tostivint H (2015) Generation of BAC transgenic tadpoles enabling live imaging of motoneurons by using the urotensin II-related peptide (ust2b) gene as a driver. PLoS One 10, e0117370.
  • Chagnaud BP, Banchi R, Simmers J & Straka H (2015) Spinal corollary discharge modulates motion sensing during vertebrate locomotion. Nature Comm, 6, 7982.
  • Kasumacic N, Lambert FM, Coulon P, Bras H, Vinay L, Perrault MC & Glover JC (2015) Segmenal organization of vestibulospinal inputs to spinal interneurons mediating crossed activation of thoracolumbar motoneurons in the neonatal mouse. J Neurosci 35, 8158-8169.
  • Nargeot R, Radecki G, Jelescu IO, Le Bihan D, Ciobanu L (2015) L’imagerie fonctionnelle des neurones individuels au sein de réseaux complexes. Med Sci (Paris) 31,15-17.
  • Toporikova N, Chevalier M & Thoby-Brisson M (2015) Sigh and eupnea rhythmogenesis involves distinct interconnected subnetworks: a combined computational and experimental study. eNeuro, 0074-14.


  • Chapuis C, Autran S, Fortin G, Simmers J & Thoby-Brisson M (2014) Emergence of sigh rhythmogenesis in the embryonic mouse. J Physiol Lond 592, 2169-2181.
  • Chevalier M, Gilbert G, Roux E, Lory P, Marthan R, Savineau JP, Quignard JF (2014) T-type calcium channels are involved in hypoxic pulmonary hypertension. Cardivasc Res 103, 597-606.
  • Le Gal JP, Juvin L, Cardoit L, Thoby-Brisson M & Morin D (2014) remote control of respiratory neural network by spinal locomotor generators. PLoS One 9, e89670.
  • Radecki G, Nargeot R, Jelescu IO, Le Bihan D, Ciobanu L (2014) Functional magnetic resonance microscopy at single-cell resolution in Aplysia californica. Proc Natl acad Sci USA 111, 8667-8672.
  • Sieling F, Bédécarrats A, Simmers J, Prinz AA & Nargeot R (2014) Differential roles of nonsynaptic and synaptic plasticity in operant reward learning-induced compulsive behavior. Curr Biol 24, 941-950.
  • Sillar KT, Combes D & Simmers J (2014) Neuromodulation in developing motor microcircuits. Curr Opin Neurobiol 29, 73-81.


  • Bédécarrats A, Cornet C, Simmers J & Nargeot R (2013) Implication of dopaminergic modulation in operant learning and the induction of compulsive-like feeding behavior in Aplysia. Learn Mem 20, 318-327.
  • Beyeler A, Rao G, Ladépêche L, Jacques A, Simmers J & Le Ray D (2013) Post-lesional plasticity of spinal posturo-locomotor networks in the metamorphosing Xenopus laevis. PLoS One 8, e71013. Doi:10.1371/journal.pone.0071013.
  • Jelescu IO, Nargeot R, Le Bihan D & Ciobanu L (2013) Highlighting manganese dynamics in the nervous system of Aplysia californica using MEMRI at ultra-high field. Neuroimage 76, 264-271.
  • von Uckermann G, Le Ray D, Combes D, Straka H & Simmers J (2013) Spinal efference copy signaling and gaze stabilization during locomotion in juvenile Xenopus laevis frogs. J. Neurosci. 33, 4253-4264.


  • Chagnaud BP, Simmers J & Straka H (2012) Predictability of visual perturbation during locomotion: implications for corrective efference copy signaling. Biol Cybern 106:669-79.
  • Clemens S, Rauscent A, Simmers J & Combes D (2012) Opposing modulatory effects of D1- and D2-like receptor activation on a spinal central pattern generator. J Neurophysiol 107:2250-2259.
  • Combes D, Sillar KT & Simmers J (2012) A switch in aminergic modulation of locomotor CPG output during amphibian metamorphosis. Front Biosci 4:1364-1374.
  • Giraudin A, Le Bon-Jego M, Cabirol MJ, Simmers J & Morin D (2012) Spinal and pontine relay pathways mediating respiratory rhythm entrainment by limb proprioceptive inputs in the neonatal rat. J Neurosci 32:11841-11853.
  • Hill AAV, Simmers J, Meyrand P & Massabuau J-C (2012) Modulation of pacemaker neurons by oxygen at the anaerobic threshold. J Comp Physiol DOI: 10.1007/s00359-012-0725-2.
  • Juvin L, Le Gal J-P, Simmers J & Morin D (2012) Cervico-lumbar coordination in mammalian quadrupedal locomotion: role of spinal thoracic circuitry and limb sensory inputs. J Neurosci 32:953-965.
  • Lambert FM, Combes D, Simmers J & Straka H (2012) Gaze stabilization by efference copy signaling without sensory feedback during vertebrate locomotion Curr Biol 22:1649-58.
  • Mellen NM & Thoby-Brisson M (2012) Respiratory circuits: developmen, function and models. Curr Opin Neurobiol (in press).
  • Simmers J (2012) Motor control: learning new moves with old pumps. Curr Biol 22:R194-196.
  • Nargeot R & Simmers J (2012) Functional organization and adaptability of a decison-making network in Aplysia. Front Neurosci 6:e113.
  • Straka H & Simmers J (2012) Xenopus laevis: An ideal experimental model for studying the developmental dynamics of neural network assembly and sensory-motor computations. Dev Neurobiol 72:649-663.
  • Thoby-Brisson M, Bouvier J, Glasco D, Stewart M, Dean C, Murdoch J, Champagnat J, Fortin G & Chandrasekhar A (2012) Brainstem respiratory oscillators develop independently of neuronal migration defects in the Wnt/PCP mutant looptail. PLos One 7:e31140.


  • Champagnat J, Morin-Surun MP, Bouvier J, Thoby-Brisson M & Fortin G (2011) Prenatal development of central rhythm generation. Resp Physiol Neurobiol 178:146-145.
  • Le Ray D, Juvin L, Ryczko D & Dubuc R (2011) Supra-spinal control of locomotion: The mesencephalic locomotor region. Prog Brain Res 188:51-70.
  • Nargeot R & Simmers J (2011) Neural mechanisms of operant conditioning and learning-induced behavioural plasticity in Aplysia. Cell Mol Life Sci 68, 803-816.
  • Ramanantsoa N, Hirsch MR, Thoby-Brisson M, Dubreuil V, Bouvier J, Ruffault PL, Matrot B, Fortin G, Brunet JF, Gallego J & Goridis C (2011) Breathing without CO2 chemosensitivity in conditional Phox2b mutants (2011) J Neurosci 31:12880-12885.


  • Bouvier J, Thoby-Brisson M, Renier N, Dubreuil V, Ericson J, Champagnat J, Pierani A, Chédotal A & Fortin G (2010) Hindbrain interneurons and axon guidance signaling critical for breathing. Nat Neurosci 13:1066-1074.
  • Caubit X, Thoby-Brisson M, Voituron N, Filippi P, Bévengut M, Faralli H, Zanella S, Fortin G, Hilaire G & Fasano L (2010) Teashirt3 regulates development of neurons involved in both respiratory rhythm and airflow control. J Neurosci 30:9465-9476.
  • Champagnat J, Thoby-Brisson M & Fortin G (2010) Genetic factors determining the functional organization of neural circuits controlling rhythmic movements: the murine embryonic parafacial rhythm generator. Prog Brain Res 187:39-46.
  • Goridis C, Dubreuil V, Thoby-Brisson M, Fortin G & Brunet JF (2010) Phox2b, congenital central hypoventilation syndrome and the control of respiration. Sem Cell Devel Biol 21:814-822.
  • Le Ray D, Juvin L, Boutin T, Auclair F & Dubuc R (2010) The mesencephalic locomotor region directly controls trigeminal inputs to reticulospinal neurons in lampreys. Eur J Neurosci 32:53-59.


  • Champagnat J, Morin-Surun MP, Fortin G & Thoby-Brisson M (2009) Developmental basis of the rostro-caudal organization of the brainstem respiratory rhythm generator. Phil Trans Roy Soc 364:2469-2476.
  • Dubreuil V, Thoby-Brisson M, Rallu M, Persson K, Pattyn A, Birchmeier C, Brunet JF, Fortin G & Goridis C (2009) Defective respiratory rhythmogenesis and loss of central chemosensitivity in Phox2b mutants targeting retrotrapezoid nucleus neurons. J Neurosci 29:14836-14846.
  • Fortin G & Thoby-Brisson M (2009) Embryonic emergence of the respiratory rhythm generator. Resp Physiol Neurobiol 168:86-91.
  • Nargeot R, Le Bon-Jego M & Simmers J (2009) Cellular and network mechanisms of operant learning-induced compulsive behavior in Aplysia. Curr Biol 19:975-985.
  • Rauscent A, Einum J, Le Ray D, Simmers J & Combes D (2009) Opposing aminergic modulation of distinct spinal locomotor circuits and their functional coupling during amphibian metamorphosis. J Neurosci 29:1163-1174.
  • Thoby-Brisson M, Karlen M, Wu N, Charnay P, Champagnat J & Fortin G (2009) Genetic identification of an embryonic parafacial oscillator coupling to the preBötzinger complex. Nat Neurosci 12:1028-1035.


  • Barrière G, Simmers J & Combes D (2008) Multiple mechanisms for integrating proprioceptive inputs that converge on the same motor pattern-generating network. J Neurosci 28:8810-8820.
  • Beyeler A, Metais C, Combes D, Simmers J & Le Ray D (2008) Metamorphosis-induced changes in the coupling of spinal thoraco-lumbar motor outputs during swimming in Xenopus laevis. J Neurophysiol 100:1372-83.
  • Bouvier J, Autran S, Dehorter N, Katz DM, Champagnat J, Fortin G & Thoby-Brisson M (2008) BDNF enhances fetal respiratory rhythm frequency in the mouse pre-Bötzinger complex in vitro. Eur J Neurosci 28:510-520.
  • Combes D, Le Ray D, Lambert F, Simmers J & Straka H (2008) An intrinsic feed-forward mechanism for vertebrate gaze stabilization. Curr Biol 18:R241-3.
  • Dubuc R, Brocard F, Antri M, Fénelon K, Gariépy JF, Smetana R, Ménard A, Le Ray D, Viana Di Prisco G, Pearlstein E, Sirota MG, Derjean D, St-Pierre M, Zielinski B, Auclair F, Veilleux D (2008) Initiation of locomotion in lampreys. Brain Res Rev 57:172-82.
  • Giraudin A, Cabirol-Pol M-J, Simmers J & Morin D (2008) Intercostal and abdominal respiratory motoneurons in the neonatal rat spinal cord: spatiotemporal organization and responses to limb afferent stimulation. J Neurophysiol 99:2626-2640.
  • Le Ray D, Le Bon-Jego M & Cattaert D (2008) Neural mechanisms of leg motor control in crayfish – insights for neurobiologically-inspired autonomous systems. In: Advancing Artificial Intelligence through Biological Process Applications, Eds. A.B. Porto, A. Pazos & W. Buño, Information Science Reference (Idea Group Inc.) pp. 20-41.
  • Sillar KT, Combes D, Ramanathan S, Molinari M & Simmers J (2008) Neuromodulation and developmental plasticity in the locomotor system of anuran amphibians during metamorphosis. Brain Res Rev 57:94-102.
  • Thoby-Brisson M & Greer JJ (2008) Anatomical and functional development of the pre-Bötzinger complex in prenatal rodents. J Appl Physiol 104:1213-1219.
  • Tryba AK, Pena F, Lieske SP, Viemari JC, Thoby-Brisson M & Ramirez JM (2008) Differential modulation of neural network and pacemaker activity underlying eupnea and sigh breathing activities. J Neurophysiol 99:2114-2125.


  • Juvin L, Simmers J & Morin D (2007) Locomotor rhythmogenesis in the isolated rat spinal cord: a phase-coupled set of symmetrical flexion-extension oscillators. J Physiol (Lond) 583:115-128.
  • Le Bon-Jego M & Yuste R (2007) Persistently-active, pacemaker-like neurons in neocortex. Front Neurosci 1:123-129.
  • Nargeot R, Petrissans C & Simmers J (2007) Behavioral and in vitro correlates of compulsive-like food-seeking induced by operant conditioning in Aplysia. J Neurosci 27:8059-8070.
  • Wrobel LJ, Ogier M, Chatonnet F, Autran S, MezièresV, Thoby-Brisson M, McLean H, Taeron C, & Champagnat J (2007) Abnormal inspiratory depth in Phox2a haploinsufficient mice. Neuroscience 145:384-392.


  • Borday C, Vias C, Autran S, Thoby-Brisson M, Champagnat J & Fortin G (2006) The pre-Bötzinger oscillator in the mouse embryo. J Physiol (Paris) 100:284-289.
  • Bouvier J, Autran S, Fortin G, Champagnat J & Thoby-Brisson M (2006) Acute role of the brain-derived neurotrophic factor (BDNF) on the respiratory neural network activity in vitro in mice. J Physiol (Paris) 100:290-296.
  • Chatonnet F, Borday C, Wrobel L, Thoby-Brisson M, Fortin G, McLean H & Champagnat J (2006) Ontogeny of central rhythm generation in chicks and rodents. Resp Physiol Neurobiol 154:37-46.
  • Knoll-Gellida A, André M, Gattegno T, Forgue J, Admon A, Babin PJ (2006) Molecular phenotype of zebrafish ovarian follicle by serial analysis of gene expression and proteomic profiling, and comparison with the transcriptomes of other animals. BMC Genomics 9:46.
  • Le Bon-Jego M, Masante-Roca I & Cattaert D (2006) State-dependent regulation of sensori-motor transmission: Role of muscarinic receptors in sensory-motor integration in the crayfish walking system. Eur J Neurosci 23:1283-1300.
  • Masson J, Darmon M, Conjard A, Chuhma N, Ropert N, Thoby-Brisson M, Foutz AS, Parrot S, Miller GM, Jorisch R, Polan J, Hamon M, Hen R & Rayport S (2006) Mice lacking brain/kidney phosphate-activated glutaminase have impaired glutamatergic synaptic transmission, altered breathing, disorganized goal-directed behavior and die shortly after birth. J Neurosci 26:4660-4671.
  • Ramanathan S, Combes D, Molinari, M, Simmers J & Sillar KT (2006) Developmental and regional expression of NADPH-diaphorase/nitric oxide synthase in spinal cord neurons correlates with the emergence of limb motor networks in metamorphosiing Xenopus laevis. Eur J Neurosci 24:1907-1922.
  • Rauscent A, Le Ray D, Cabirol-Pol MJ, Sillar KT, Simmers J & Combes D (2006) Development and neuromodulation of spinal locomotor networks in the metamorphosing frog. J Physiol (Paris) 100:317-327.
  • Tingaud-Sequeira A, Forgue J, André M, Babin PJ (2006) Epidermal transient down-regulation of retinol-binding protein 4 and mirror expression of apolipoprotein Eb and estrogen receptor 2a during zebrafish fin and scale development. Dev Dyn 235: 3071-9.
  • Wallen-McKenzie A, Gezelius H, Thoby-Brisson M, Nygard A, Enjin A, Fujiyama F, Fortin G & Kullander K (2006) VGLUT2 is required for central respiratory rhythm but not for locomotor central pattern generation. J Neurosci 26:12294-12307.


  • Borday C, Chatonnet F, Thoby-Brisson M, Champagnat J & Fortin G (2005) Neural tube patterning by Krox20 and emergence of a respiratory control. Resp Physiol Neurobiol 149:63-72.
  • Combes D, Merrywest SD, Simmers J & Sillar KT (2005) Metamorphosis from tadpole to frog: a tale of two networks. Physiol News 58:17-18. (Feature article solicited by The Physiological Society (Lond.) following article Combes et al (2004) J Physiol (Lond) 559:17-24)
  • Cotto E, André M, Forgue J, Fleury HJ, Babin PJ (2005) Molecular characterization, phylogenetic relationships, and developmental expression patterns of prion genes in zebrafish (Danio rerio). FEBS J 272:500-13.
  • Faumont S*, Combes D*, Meyrand P & Simmers J (2005) Motor network reconfiguration by short- and long-term actions of a single modulatory neuron. Eur J Neurosci 22:2489-2002 (* co-first authors)
  • Ikegaya Y, Le Bon-Jego M & Yuste R (2005) Large-scale imaging of cortical network activity with calcium indicators. Neurosci Res 52:132-8.
  • Juvin L, Simmers J & Morin D (2005) Propriospinal circuitry underlying interlimb coordination in mammalian quadrupedal locomotion. J Neurosci 25:6025-6035.
  • Le Ray D, Combes D, Dejean C & Cattaert D (2005) Plasticity of proprioceptive coding and antidromic activity in the freely behaving crayfish. J Neurophysiol 94:1013-1027.
  • Thoby-Brisson M, Trinh JB, Champagnat J & Fortin G (2005) Emergence of the pre-Bötzinger respiratory rhythm generator in the mouse embryo. J Neurosci 25:4307-4318.
  • Watson A, Le Bon-Jego M & Cattaert D (2005) Central inhibitory microcircuits controlling spike propagation into sensory terminals. J Comp Neurol 484:234-48.