Institut de Neurosciences Cognitives et Intégratives d'Aquitaine (UMR5287)

Aquitaine Institute for Cognitive and Integrative Neuroscience


INCIA - UMR 5287- CNRS
Université de Bordeaux

Zone nord Bat 2 2ème étage
146, rue Léo Saignat
33076 Bordeaux cedex
France

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CNRS Ecole Pratique des Hautes Etudes Université de Bordeaux

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Welcome to Dr Sighild Lemarchant, recently appointed as a postdoc in the Brain Molecular Imaging team

by Loïc Grattier - published on

Dr Lemarchant’s research interests are the roles of extracellular matrix (ECM) in the process of the central nervous system (CNS) remodeling in normal and pathological situations with a particular focus on proteoglycans and proteases. After her PhD training (2008-2011) in Pr Denis Vivien’s laboratory (INSERM U919, Caen, France), she moved to Kuopio (Finland) in Pr Jari Koistinaho’s laboratory at the AI Virtanen Institute for Molecular Sciences for a post-doctoral stay from 2012 to 2016. After studying the effect of tissue plasminogen activator (tPA) and type 4 a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS-4) on ECM remodeling and neuroplasticity after spinal cord injury during her PhD, she pursued on investigating the effect of ECM remodeling by tPA or ADAMTS-4 in other CNS pathologies (eg. ischemic stroke and amyotrophic lateral sclerosis).
Dr Lemarchant recently joined Dr Jérôme Badaut’s group (Brain Molecular Imaging) as a post-doctoral fellow of the Era-Net Neuron program TRAINS, coordinated by Dr Barrière and Dr Badaut. She will work on the contribution of remote CNS changes in sensorimotor and cognitive dysfunctions after traumatic brain and spinal cord injuries.

Selected publications
Dhungana H, Huuskonen M, Pihlajaniemi T, Heljasvaara R, Vivien D, Kanninen K, Malm T, Koistinaho J, Lemarchant S. Lack of collagen XV is beneficial after ischemic stroke in mice. Cell Death and Disease. 2017, 8(1):e2541. doi: 10.1038/cddis.2016.456.
Lemarchant S, Dhungana H, Pomeshchik Y, Leinonen H, Kolosowska N, Korhonen P, Kanninen KM, García-Berrocoso T, Montaner J, Malm T, Koistinaho J. Anti-inflammatory effects of ADAMTS-4 in a mouse model of ischemic stroke. Glia. 2016, 64(9):1492-1507. doi: 10.1002/glia.23017.
Lemarchant S, Pomeshchik Y, Kidin I, Kärkkäinen V, Valonen P, Lehtonen S, Goldsteins G, Malm T, Kanninen K, Koistinaho J. ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis. Molecular Neurodegeneration. 2016, 11(1):10. doi: 10.1186/s13024-016-0078-3.
Lemarchant S, Pruvost M, Hébert M, Gauberti M, Hommet Y, Briens A, Maubert E, Gueye Y, Féron F, Petite D, Mersel M, do Rego JC, Vaudry H, Koistinaho J, Ali C, Agin V, Emery E, Vivien D. tPA promotes ADAMTS-4-induced CSPG degradation, thereby enhancing neuroplasticity following spinal cord injury. Neurobiology of Disease. 2014, 66:28-42. doi: 10.1016/j.nbd.2014.02.005.