Institut de Neurosciences Cognitives et Intégratives d'Aquitaine (UMR5287)

Aquitaine Institute for Cognitive and Integrative Neuroscience



INCIA - UMR 5287- CNRS
Université de Bordeaux

Zone nord Bat 2 2ème étage
146, rue Léo Saignat
33076 Bordeaux cedex
France

Téléphone 05.57.57.15.51
Télécopie 05.56.90.14.21

Supervisory authorities

CNRS Ecole Pratique des Hautes Etudes Université de Bordeaux

Our partners

Neurocampus Unitéde Formation de Biologie

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Home > Teams > OASM (M. THOBY-BRISSON)

Research Interest

by Le Ray Didier, Loïc Grattier - published on , updated on

Our overall research objective is to decipher the neuronal basis of the short- and long-term functional plasticity of motor systems, with the principal experimental goal of trying to relate cellular, synaptic and neural network physiology to particular aspects of adaptive behavior. By combining behavioral analysis (kinematics, electromyography) with cellular and integrative neurobiology (extra- and intracellular electrophysiology, functional imaging, dynamic clamp technology, neuroanatomy, transgenesis...), the team pursues four main research axes with three animal models. Firstly, by investigating identified neurons and motor circuitry in the mollusk Aplysia, we are determining the cellular and network substrates through which the animal’s goal-directed, food-seeking behavior is durably modified by appetitive operant learning via dopaminergic neuromodulation. Second, we are exploring the mechanisms by which sensory signaling and brainstem neuromodulatory influences govern both the dynamic adaptability and developmental plasticity of spinal motor circuitry in the amphibian Xenopus, as it transforms from tail- to limb-based locomotion during metamorphosis. Third, also with Xenopus, we are studying how efferent copies of spinal locomotory commands interact with brainstem vestibular and oculomotor circuitry to produce compensatory eye movements during locomotion and how these inter-network interactions are remodeled during the course of metamorphic development. Fourth, in the mouse, we are exploring the cellular and synaptic processes by which respiratory rhythmogenic circuitry during embryonic development acquires the ability to generate multiple output patterns and the role that neuromodulatory and activity-dependent influences play in the emergence of this multi-functionality.