Institut de Neurosciences Cognitives et Intégratives d'Aquitaine (UMR5287)

Aquitaine Institute for Cognitive and Integrative Neuroscience

Université de Bordeaux

Zone nord Bat 2 2ème étage
146, rue Léo Saignat
33076 Bordeaux cedex


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CNRS Ecole Pratique des Hautes Etudes Université de Bordeaux

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Neurocampus Unitéde Formation de Biologie


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Home > Agenda

Thursday 14 th March 2019 ,The next INCIA monthly seminar

by Loïc Grattier - published on , updated on

The next INCIA monthly seminar : Thursday, March 14, from 11h30 am to 12h30 pm in the meeting room of building 2A (second floor) in Carreire.
HERE: REGISTRATION Auberge Espagnole.

The speakers will be:
Muriel Thoby-Brisson (Research director,OASM team) :
Toward a treatment for Ondine Syndrome

Ondine syndrome is a rare congenital disease which is due to mutations of the PHOX2B transcription factor that plays a key role in the development of the autonomic nervous system and respiratory networks. The disease is characterized by a strong decrease of breathing activity during sleep which requires mechanical respiratory assistance for survival. Mice carrying the PHOX2B mutation present the main symptoms of the disease (hypoventilation and loss of chemosensitivity), and newborn pups, because of a lack of ventilation, die within hours after birth. It was shown from human cells cultures that the mutation triggers the accumulation of PHOX2B aggregates that disrupt its transcriptional function. The geldanamycine (an antibiotic), or its derivate 17-AGG, would decrease the formation of PHOX2B aggregates and restore its transcriptional activity. From these studies, we hypothesize that 17-AAG could decrease the respiratory deficit observed in mice carrying PHOX2B mutation and increase their survival rate. Our project aims at testing the action of 17-AAG onto the activity of the respiratory network and its chemosensitivity from in vitro isolated reduced brainstem preparations.

Loïc Bordes (PhD student, Neurobiology of Behavior team) :
Hippocampal activity and social stimuli in the Shank3 mouse model of autism spectrum disorders
Summury to come