Institut de Neurosciences Cognitives et Intégratives d'Aquitaine (UMR5287)

Aquitaine Institute for Cognitive and Integrative Neuroscience

Université de Bordeaux

Zone nord Bat 2 2ème étage
146, rue Léo Saignat
33076 Bordeaux cedex


Supervisory authorities

CNRS Ecole Pratique des Hautes Etudes Université de Bordeaux

Our partners

Neurocampus Unitéde Formation de Biologie


GDR Robotique GDR Mémoire GDR Multi-électrodes


Home > Teams > ADDICTEAM (M. CADOR)


by Loïc Grattier - published on , updated on

Recent Publications 2016- 2019
- Noe, E., Bonneau, N. , Fournier, M. L. , Caille, S. , Cador, M. , & Le Moine, C. (2019). Arc reactivity in accumbens nucleus, amygdala and hippocampus differentiates cue over context responses during reactivation of opiate withdrawal memory. Neurobiol Learn Mem, 159, 24-35.
- Vandaele Y., Noe E., Cador M., Dellu-Hagedorn F., Caille S. (2018) Attentional capacities prior to drug exposure predict motivation to self-administer nicotine. Psychopharmacology (Berl), 235, 2041-2050.
- Gueye A.B., Vendruscolo L.F., de Ávila C., Le Moine C., Darnaudéry M., Cador M. (2018) Unlimited sucrose consumption during adolescence generates a depressive-like phenotype in adulthood. Neuropsychopharmacology, 43, 2627-2635.
- Morisot N., Monier R., Le Moine C., Millan M.J., Contarino A. (2018) CRF2 receptor-deficiency eliminates social behaviour deficits and vulnerability induced by cocaine. Br J Pharmacol. doi: 10.1111/bph.14159.
- Naneix F., Darlot F., De Smedt-Peyrusse V., Pape J.R., Coutureau E., Cador M. (2018) Protracted motivational dopamine-related deficits following adolescence sugar overconsumption. Neuropharmacology. 129, 16-25
- Fitoussi A, Renault P, Le Moine C, Coutureau E, Cador M, Dellu-Hagedorn F (2018) Inter-individual differences in decision-making, flexible and goal-directed behaviors: novel insights within the prefronto-striatal networks. Brain Structure & Function. 223:897-912.
- Dellu-Hagedorn F., De Deurwaerdere P., Fitoussi A (2017) Correlative analysis of dopaminergic and serotonergic metabolism across the brain to study monoaminergic function and interaction. Journal of Neuroscience Methods. 280, 54-63.
- Glangetas C, Massi L, Fois GR, Jalabert M, Girard D, Diana M, Yonehara K, Roska B, Xu C, Luthi A, Caille S, Georges F (2017) NMDA-receptor-dependent plasticity in the bed nucleus of the stria terminalis triggers long-term anxiolysis. Nature Communications 8:14456.
- Dejean C, Sitko M, Girardeau P, Bennabi A, Caillé S, Cador M, Boraud T, Le Moine C (2017) Memories of opiate withdrawal emotional states correlate with specific gamma oscillations in the nucleus accumbens. Neuropsychopharmacology 42:1157-1168.
- Simonnet A, Zamberletti E, Cador M, Rubino T, Caillé S (2017) Chronic FAAH inhibition during nicotine abstinence alters habenular CB1 receptor activity and precipitates depressive-like behaviors, Neuropharmacology. 113:252-259.
- Romani Perez M, Lépinay M, Alonso L, Rincel M, Xia L, Fanet H, Caillé S, Cador M, Laye S, Vancassel S, Darnaudery M (2016) Impact of a maternal high fat diet and maternal separation on energy homeostasis and food-motivated behavior, Int J Obesity 41 : 502-509.
- Naneix F, Darlot F, Coutureau E, Cador M (2016) Long-lasting deficits in hedonic and nucleus accumbens reactivity to sweet rewards by sugar overconsumption during adolescence. European Journal of Neuroscience, 43, 671–680.

- Fitoussi A, Le Moine C, De Deurwaerdere P., Laqui M, Rivalan M, Cador M and Dellu-Hagedorn F. (2015) Prefronto-subcortical imbalance characterizes poor decision-making: neurochemical and neural functional evidences in rats. Brain Struct Funct 220: 1863-2653.
- Morisot N., Rouibi K. & Contarino A. (2015) CRF2 receptor-deficiency eliminates the long-lasting vulnerability of motivational states induced by opiate withdrawal, Neuropsychopharmacology, 40 : 1990-2002.
- Hachem-Delaunay S, Fournier ML, Cohen C, Bonneau N, Cador M, Baunez C, Le Moine C (2015) Subthalamic nucleus high-frequency stimulation modulates neuronal reactivity to cocaine within the reward circuit. Neurobiol Dis 80:54-62
- Glangetas C, Fois GR, Jalabert M, Lecca S, Valentinova K, Meye FJ, Diana M, Faure P, Mameli M, Caille S, Georges F (2015) Ventral Subiculum Stimulation Promotes Persistent Hyperactivity of Dopamine Neurons and Facilitates Behavioral Effects of Cocaine. Cell reports 13:2287-2296.

- Reisiger AR, Kaufling J, Manzoni O, Cador M, Georges F, Caille S, Nicotine self-administration induces CB1-dependent LTP in the Bed Nucleus of the Stria Terminalis. J of Neuroscience, (2014) 34:4285-92.
- Morisot N, Le Moine C, Millan MJ & Contarino A (2014) CRF2 receptor-deficiency reduces recognition memory deficits and vulnerability to stress induced by cocaine withdrawal. Int J Neuropsychopharmacol 17 : 1969-1979.
- Morisot N, Millan MJ, Contarino A (2014) CRF1 receptor-deficiency induces anxiety-like vulnerability to cocaine. Psychopharmacology. ;231(20):3965-72.
- Lu B, Diz-Chaves Y, Markovic D, Contarino A , Penicaud L, Fanelli F, Clark S, Lehnert H, Cota D, Grammatopoulos DK, Tabarin A (2014) The corticotrophin-releasing factor/urocortin system regulates white fat browning in mice through paracrine mechanisms. Int J Obes (Lond). 39 :408-417


- Dejean C, Boraud T, Le Moine C (2013) Opiate dependence induces network state shifts in the limbic system. Neurobiol Dis., Nov;59:220-9.
- Baldo BA, Pratt WE, Will MJ, Hanlon EC, Bakshi VP, Cador M (2013) Principles of motivation revealed by the diverse functions of neuropharmacological and neuroanatomical substrates underlying feeding behavior. Neurosci Biobehav Rev., Nov;37:1985-98.
- Rouibi K, Contarino A (2013) The corticotropin-releasing factor receptor-2 mediates the motivational effect of opiate withdrawal. Neuropharmacology. Oct;73:41-7.
- Lardeux S, Paleressompoulle D, Pernaud R, Cador M, Baunez C (2013) Different populations of subthalamic neurons encode cocaine vs. sucrose reward and predict future error. J Neurophysiol. Oct;110(7):1497-510.
- Rivalan M, Valton V, Seriès P, Marchand A and Dellu-Hagedorn F (2013) Elucidating poor decision making in a rat gambling task. Plos One 8(12):e82052. see online
- Fitoussi A, De Deurwaerdere P and Dellu-Hagedorn F (2013) Monoamines tissue measurement reveals specific and restricted correlations of their content in some brain regions involved in cognition. Neuroscience, Dec 26;255:233-45.
- Van Den Bos R, Davies W, Dellu-Hagedorn F, Goudriaan A, Granon S, Homberg J, Rivalan M, Swendsen J and Adriani W (2013) Cross-species approaches to pathological gambling: a review targeting sex differences, adolescence and ecological validity of research tools. Neuroscience and Biobehavioral reviews 37: 2454–2471.
- Simonnet A, Cador M, Caille S (2013) Nicotine reinforcement is reduced by cannabinoid CB1 receptor blockade in the ventral tegmental area. Addict Biol. Nov; 18(6): 930-6
- Engeln M, Fasano S, Ahmed SH, Cador M, Baekelandt V, Bezard E & Fernagut P-O (2013) Levodopa Gains Psychostimulant-Like Properties after Nigral Dopaminergic Loss. Annals of Neurology 74, 140-144.
- Krawczyk M, Mason X, DeBacker J, Sharma R, Normandeau CP, Hawken ER, Di Prospero C, Chiang C, Martinez A, Jones AA, Doudnikoff E, Caille S, Bezard E, Georges F & Dumont EC (2013) D1 Dopamine Receptor-Mediated LTP at GABA Synapses Encodes Motivation to Self-Administer Cocaine in Rats. Journal of Neuroscience 33, 11960
- Navailles S, Lagiere M, Le Moine C & De Deurwaerdere P (2013) Role of 5-HT2C receptors in the enhancement of c-Fos expression induced by a 5-HT2B/2C inverse agonist and 5-HT2 agonists in the rat basal ganglia. Experimental Brain Research 230, 525-535.
- Navailles S, Lagiere M, Roumegous A, Polito M, Boujema MB, Cador M, Dunlop J, Chesselet M-F, Millan MJ & De Deurwaerdere P (2013) Serotonin(2C) ligands exhibiting full negative and positive intrinsic activity elicit purposeless oral movements in rats: distinct effects of agonists and inverse agonists in a rat model of Parkinson’s disease. International Journal of Neuropsychopharmacology 16, 593-606.
- Pittiras E, Cresssant A, Serreau P, Bruijel J, Dellu-Hagedorn F, Callebert J, Rabat A. and Granon S. (2013) Mice Gamble for Food: Individual Differences in Risky Choices and Prefrontal Cortex Serotonin. J Addict Res Ther S4: 011.


- Grégoire S, Rivalan M, Le Moine C and Dellu-Hagedorn F (2012) The synergy of working memory and inhibitory control: behavioral, pharmacological and neural functional evidences. Neurobiol. Learn. Mem., 97: 202-212.
- Ingallinesi M, Rouibi K, Le Moine C, Papaleo F, Contarino A (2012) CRF2 receptor-deficiency eliminates opiate withdrawal distress without impairing stress-coping. Mol Psychiatry. 17:1283-94.
- Rouibi K, Contarino A (2012) Increased motivation to eat in opiate-withdrawn mice. Psychopharmacology (Berl). Jun;221(4):675-84.
- Caille S, Clemens K, Stinus L, Cador M (2012) Modeling nicotine addiction in rats. Methods Mol Biol. 2012;829:243-56.
- Lucas M, Frenois F, Cador M and Le Moine C (2012) Remodeling of the neuronal circuits underlying opiate-withdrawal memories following remote reactivation. Neurobiology of Learning and Memory 97:47-53.
- Dejean C, Nadjar A, Le Moine C, Bioulac B, Gross CE, Boraud T (2012) Evolution of the dynamic properties of the cortex-basal ganglia network after dopaminergic depletion in rats. Neurobiol Dis. 2012 May;46(2):402-13.

- Dejean C, Arbuthnott G, Wickens JR, Le Moine C, Boraud T, Hyland BI (2011) Power fluctuations in beta and gamma frequencies in rat globus pallidus: association with specific phases of slow oscillations and differential modulation by dopamine D1 and D2 receptors. J Neurosci 31:6098-6107.
- de Visser L, Homberg JR, Mitsogiannis M, Zeeb FD, Rivalan M, Fitoussi A, Galhardo V, van den Bos R, Winstanley CA and Dellu-Hagedorn F (2011) Rodent versions of the Iowa gambling task: opportunities and challenges for the understanding of decision-making. Front. Neurosci. 5:109.
see online
-  Rivalan M, Coutureau E, Fitoussi A, Dellu-Hagedorn F (2011) Inter-individual decision-making differences in the effects of cingulate, orbitofrontal, and prelimbic cortex lesions in a rat gambling task. Front Behav Neurosci 5:22.
see online


- Beyeler A, Kadiri N, Ben Boujema M, Gonon F, Le Moine C, Gross C and De Deurwaerdere P (2010) Stimulation of serotonin2c receptors elicits abnormal oral movements by acting on pathways other than the sensori-motor one in rat basal ganglia Neuroscience 169, 158-170.
- Clemens KJ, Caille S, Cador M (2010) The effects of response operandum and prior food training on intravenous nicotine self-administration in rats. Psychopharmacology (Berl) 211:43-54.
- De Deurwaerdere P, Le Moine C, Chesselet MF (2010) Selective blockade of serotonin 2C receptor enhances Fos expression specifically in the striatum and the subthalamic nucleus within the basal ganglia. Neurosci Lett 469:251-255.
- Richard EM, Helbling JC, Tridon C, Desmedt A, Minni AM, Cador M, Pourtau L, Konsman JP, Mormede P, Moisan MP (2010) Plasma transcortin influences endocrine and behavioral stress responses in mice. Endocrinology 151:649-659.
- Rouaud T, Lardeux S, Panayotis N, Paleressompoulle D, Cador M, Baunez C (2010) Reducing the desire for cocaine with subthalamic nucleus deep brain stimulation. Proc Natl Acad Sci U S A 107:1196-1200.
- Vendruscolo LF, Gueye AB, Darnaudery M, Ahmed SH, Cador M (2010) Sugar overconsumption during adolescence selectively alters motivation and reward function in adult rats. PLoS One 5:e9296.
see online
- Vendruscolo LF, Gueye AB, Vendruscolo JC, Clemens KJ, Mormede P, Darnaudery M, Cador M (2010) Reduced alcohol drinking in adult rats exposed to sucrose during adolescence. Neuropharmacology 59:388-394.


- Barbano MF, Le Saux M, Cador M (2009) Involvement of dopamine and opioids in the motivation to eat: influence of palatability, homeostatic state, and behavioral paradigms. Psychopharmacology (Berl) 203:475-487.
- Berthet A, Porras G, Doudnikoff E, Stark H, Cador M, Bezard E, Bloch B (2009) Pharmacological analysis demonstrates dramatic alteration of D1 dopamine receptor neuronal distribution in the rat analog of L-DOPA-induced dyskinesia. J Neurosci 29:4829-4835.
- Caille S, Guillem K, Cador M, Manzoni O, Georges F (2009) Voluntary nicotine consumption triggers in vivo potentiation of cortical excitatory drives to midbrain dopaminergic neurons. J Neurosci 29:10410-10415.
- Clemens KJ, Caille S, Stinus L, Cador M (2009) The addition of five minor tobacco alkaloids increases nicotine-induced hyperactivity, sensitization and intravenous self-administration in rats. Int J Neuropsychopharmacol 12:1355-1366.
- Consoli D, Contarino A, Tabarin A, Drago F (2009) Binge-like eating in mice. Int J Eat Disord 42:402-408.
-  Rivalan M, Ahmed SH, Dellu-Hagedorn F (2009) Risk-prone individuals prefer the wrong options on a rat version of the Iowa Gambling Task. Biol Psychiatry 66:743-749.
- Rivalan M, Blondeau C, Dellu-Hagedorn F (2009) Modeling symptoms of mental disorders using a dimensional approach in the rat. In: Endophenotypes of psychiatric and neurodegenerative disorders in rodent models (Granon S, ed). Kerala, India: Transworld Research Network.


- Guillem K, Vouillac C, Koob GF, Cador M, Stinus L Monoamine oxidase inhibition dramatically prolongs the duration of nicotine withdrawal-induced place aversion. Biol Psychiatry 63:158-163.
-  Keiflin R, Isingrini E, Cador M Cocaine-induced reinstatement in rats: evidence for a critical role of cocaine stimulus properties. Psychopharmacology (Berl) 197:649-660.
- Keiflin R, Vouillac C, Cador M Level of operant training rather than cocaine intake predicts level of reinstatement. Psychopharmacology (Berl) 197:247-261.
- Lucas M, Frenois F, Vouillac C, Stinus L, Cador M, Le Moine C Reactivity and plasticity in the amygdala nuclei during opiate withdrawal conditioning: differential expression of c-fos and arc immediate early genes. Neuroscience 154:1021-1033.
- Papaleo F, Ghozland S, Ingallinesi M, Roberts AJ, Koob GF, Contarino A Disruption of the CRF(2) receptor pathway decreases the somatic expression of opiate withdrawal. Neuropsychopharmacology 33:2878-2887.


- Barbano MF, Cador M Opioids for hedonic experience and dopamine to get ready for it. Psychopharmacology (Berl) 191:497-506.
- Bessiere B, Richebe P, Laboureyras E, Laulin JP, Contarino A, Simonnet G Nitrous oxide (N2O) prevents latent pain sensitization and long-term anxiety-like behavior in pain and opioid-experienced rats. Neuropharmacology 53:733-740.
- Blondeau C, Dellu-Hagedorn F Dimensional analysis of ADHD subtypes in rats. Biol Psychiatry 61:1340-1350.
- Caille S, Alvarez-Jaimes L, Polis I, Stouffer DG, Parsons LH Specific alterations of extracellular endocannabinoid levels in the nucleus accumbens by ethanol, heroin, and cocaine self-administration. J Neurosci 27:3695-3702.
- Mingaud F, Le Moine C, Etchamendy N, Mormede C, Jaffard R, Marighetto A The hippocampus plays a critical role at encoding discontiguous events for subsequent declarative memory expression in mice. Hippocampus 17:264-270.
- Pacchioni AM, Cador M, Bregonzio C, Cancela LM A glutamate-dopamine interaction in the persistent enhanced response to amphetamine in nucleus accumbens core but not shell following a single restraint stress. Neuropsychopharmacology 32:682-692.
- Papaleo F, Kieffer BL, Tabarin A, Contarino A Decreased motivation to eat in mu-opioid receptor-deficient mice. Eur J Neurosci 25:3398-3405.
- Papaleo F, Kitchener P, Contarino A Disruption of the CRF/CRF1 receptor stress system exacerbates the somatic signs of opiate withdrawal. Neuron 53:577-589.
- Rivalan M, Gregoire S, Dellu-Hagedorn F Reduction of impulsivity with amphetamine in an appetitive fixed consecutive number schedule with cue for optimal performance in rats. Psychopharmacology (Berl) 192:171-182.
- Tabarin A, Diz-Chaves Y, Consoli D, Monsaingeon M, Bale TL, Culler MD, Datta R, Drago F, Vale WW, Koob GF, Zorrilla EP, Contarino A Role of the corticotropin-releasing factor receptor type 2 in the control of food intake in mice: a meal pattern analysis. Eur J Neurosci 26:2303-2314.
- Vancassel S, Blondeau C, Lallemand S, Cador M, Linard A, Lavialle M, Dellu-Hagedorn F Hyperactivity in the rat is associated with spontaneous low level of n-3 polyunsaturated fatty acids in the frontal cortex. Behav Brain Res 180:119-126.
- Zittel-Lazarini A, Cador M, Ahmed SH A critical transition in cocaine self-administration: behavioral and neurobiological implications. Psychopharmacology (Berl) 192:337-346.


- Ahmed SH, Cador M Dissociation of psychomotor sensitization from compulsive cocaine consumption. Neuropsychopharmacology 31:563-571.
- Barbano MF, Cador M Differential regulation of the consummatory, motivational and anticipatory aspects of feeding behavior by dopaminergic and opioidergic drugs. Neuropsychopharmacology 31:1371-1381.
-  Caille S, Parsons LH Cannabinoid modulation of opiate reinforcement through the ventral striatopallidal pathway. Neuropsychopharmacology 31:804-813.
- Dellu-Hagedorn F Relationship between impulsivity, hyperactivity and working memory: a differential analysis in the rat. Behav Brain Funct 2:10.
- Georges F, Le Moine C, Aston-Jones G No effect of morphine on ventral tegmental dopamine neurons during withdrawal. J Neurosci 26:5720-5726.
- Guillem K, Vouillac C, Azar MR, Parsons LH, Koob GF, Cador M, Stinus L Monoamine oxidase A rather than monoamine oxidase B inhibition increases nicotine reinforcement in rats. Eur J Neurosci 24:3532-3540.
- Lenoir M, Keiflin R Heroin addiction: anticipating the reward of heroin or the agony of withdrawal? J Neurosci 26:9080-9081.
- Mallet N, Ballion B, Le Moine C, Gonon F Cortical inputs and GABA interneurons imbalance projection neurons in the striatum of parkinsonian rats. Journal of Neuroscience 26:3875-3884.
- Papaleo F, Contarino A Gender- and morphine dose-linked expression of spontaneous somatic opiate withdrawal in mice. Behav Brain Res 170:110-118.
- Tseng KY, Mallet N, Toreson KL, Le Moine C, Gonon F, O’Donnell P Excitatory response of prefrontal cortical fast-spiking interneurons to ventral tegmental area stimulation in vivo. Synapse 59:412-417.


- Barbano MF, Cador M Various aspects of feeding behavior can be partially dissociated in the rat by the incentive properties of food and the physiological state. Behav Neurosci 119:1244-1253.
- Barbano MF, Stinus L, Cador M, Ahmed SH Mesolimbic dopamine drives the diurnal variation in opiate-induced feeding. Pharmacology Biochemistry and Behavior 81:569-574.
- Baunez C, Dias C, Cador M, Amalric M The subthalamic nucleus exerts opposite control on cocaine and ’natural’ rewards. Nat Neurosci 8:484-489.
- Contarino A, Papaleo F The corticotropin-releasing factor receptor-1 pathway mediates the negative affective states of opiate withdrawal. Proc Natl Acad Sci U S A 102:18649-18654.
- Dellu-Hagedorn F Spontaneous individual differences in cognitive performances of young adult rats predict locomotor response to amphetamine. Neurobiology of Learning and Memory 83:43-47.
-  Frenois F, Le Moine C, Cador M The motivational component of withdrawal in opiate addiction: role of associative learning and aversive memory in opiate addiction from a behavioral, anatomical and functional perspective. Rev Neurosci 16:255-276.
- Frenois F, Stinus L, Di Blasi F, Cador M, Le Moine C A specific limbic circuit underlies opiate withdrawal memories. Journal of Neuroscience 25:1366-1374.
- Georges F, Caille S, Vouillac C, Le Moine C, Stinus L Role of imidazoline receptors in the anti-aversive properties of clonidine during opiate withdrawal in rats. Eur J Neurosci 22:1812-1816.
- Guillem K, Vouillac C, Azar MR, Parsons LH, Koob GF, Cador M, Stinus L Monoamine oxidase inhibition dramatically increases the motivation to self-administer nicotine in rats. J Neurosci 25:8593-8600.
- Mallet N, Le Moine C, Charpier S, Gonon F Feedforward inhibition of projection neurons by fast-spiking GABA interneurons in the rat striatum in vivo. J Neurosci 25:3857-3869.
- Stinus L, Cador M, Zorrilla EP, Koob GF Buprenorphine and a CRF1 antagonist block the acquisition of opiate withdrawal-induced conditioned place aversion in rats. Neuropsychopharmacology 30:90-98.


- Caille S, Parsons LH Intravenous heroin self-administration decreases GABA efflux in the ventral pallidum: an in vivo microdialysis study in rats. Eur J Neurosci 20:593-596.
- Dellu-Hagedorn F, Trunet S, Simon H Impulsivity in youth predicts early age-related cognitive deficits in rats. Neurobiol Aging 25:525-537.
- Dias C, Lachize S, Boilet V, Huitelec E, Cador M Differential effects of dopaminergic agents on locomotor sensitisation and on the reinstatement of cocaine-seeking and food-seeking behaviour. Psychopharmacology (Berl) 175:414-427.