Institut de Neurosciences Cognitives et Intégratives d'Aquitaine (UMR5287)

Aquitaine Institute for Cognitive and Integrative Neuroscience



INCIA - UMR 5287- CNRS
Université de Bordeaux

Zone nord Bat 2 2ème étage
146, rue Léo Saignat
33076 Bordeaux cedex
France

Téléphone 05.57.57.15.51
Télécopie 05.56.90.14.21

Supervisory authorities

CNRS Ecole Pratique des Hautes Etudes Université de Bordeaux

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Neurocampus Unitéde Formation de Biologie

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Home > Teams > ADDICTEAM (M. CADOR)

Research Interest

by Catherine Le Moine - published on , updated on

ADDICTEAM aims at understanding the behavioral and neurobiological processes involved in addiction in rodent models. We aim at studying: 1) specific populations (such as adolescents) or specific individuals (with executive function deficits for instance) who demonstrate higher vulnerability to addiction processes; 2) what are the behavioral substrates altered by drugs which promote recurrent drug taking, seeking and relapse; and 3) how alterations within brain circuits may sustain these behavioral modifications. Our work combines behavioral paradigms evaluating cognitive, emotional and reinforcement processes with neurobiological approaches ranging from intra-cerebral pharmacology, in vivo and in vitro electrophysiology (in behaving animals, anaesthetized animals and slices) and functional neuroanatomy.

Addicteam Project
Addicteam Project

Addiction is a long lasting process which takes years to remit and, for some substances (nicotine or alcohol), with very early onset (critical period). Repeated exposures to pharmacological rewards induce adaptations to some effects of the drug itself (behavioral sensitization, tolerance, dependence) and at the meso-cortico-limbic network level (VTA-NAC-AMY-PFC-HPC). These adaptations bias behaviors towards drugs at the expense of natural rewards via pathological wanting, persistent drug or withdrawal-related memories, habit formation, decision making deficits and recurrent relapse. All of these factors indicate that the drug-exposed brain encodes information, builds representations and attributes values in a wrong way leading to recurrent drug seeking behavior.

Four main research lines:

  • Vulnerability to addiction: cumulative effects of traits, environment and risk period
  • Drug induced sensitization and drug relapse
  • Crucial factors for addiction
  • Persistent drug memories and relapse