Institut de Neurosciences Cognitives et Intégratives d'Aquitaine (UMR5287)

Aquitaine Institute for Cognitive and Integrative Neuroscience

Université de Bordeaux

Zone nord Bat 2 2ème étage
146, rue Léo Saignat
33076 Bordeaux cedex


Supervisory authorities

CNRS Ecole Pratique des Hautes Etudes Université de Bordeaux

Our partners

Neurocampus Unitéde Formation de Biologie


GDR Robotique GDR Mémoire GDR Multi-électrodes


Home > Teams > HYBRID ( De RUGY) > Themes

Theme 8: Morphogenesis and Biomechanics of Connective Tissues

by Loïc Grattier - published on , updated on

We study the motion of cell masses during morphogenesis in order to identify links and relationships between diverse anatomical structures in humans. These links have major roles in proprioception, coordination as well as in force and information transmission. They participate in the general synchronisation and harmony of the system, and in compensatory strategies during motor activities. These direct links between the skeletal, muscular and nervous systems can be neurological or mechanical, and have a physical basis in the connective tissues (CT) and fascias that connect them.
The study of the CT network enables to apprehend their implications in motor control in general, and has applications in clinics, robotics, and biomechanical modelling.

Project 1
: Study of systematic motion of cell masses and their differentiation during morphogenesis.

Project 2: Dissections of the upper limb and lower limb are used to identify, map and qualify the connective tissues linking the different systems. These dissections enable to distinguish two categories of transmission: neurological and mechanical ones.

Project 3
: Our grasp of the relationship between muscles and the CT network allows to improve current models: (i) of the nervous system, taking additional neuronal receptors into account, and (ii) of the musculoskeletal system, considering mechanical force transmission between the muscle and other regions than the tendons (myofascial), to better account for muscular functions and mechanics.

- Seyres, Martin, and Philippe Seyres. “Connective Tissues of the Posterior Aspect of the Trunk.” In “Spinal Anatomy: Modern Concepts”, by Jean-Marc Vital and Derek Thomas Cawley, Springer, 2020, pp. 329–343.