Institut de Neurosciences Cognitives et Intégratives d'Aquitaine (UMR5287)

Aquitaine Institute for Cognitive and Integrative Neuroscience

Université de Bordeaux

Zone nord Bat 2 2ème étage
146, rue Léo Saignat
33076 Bordeaux cedex


Supervisory authorities

CNRS Ecole Pratique des Hautes Etudes Université de Bordeaux

Our partners

Neurocampus Unitéde Formation de Biologie


GDR Robotique GDR Mémoire GDR Multi-électrodes


Home > Teams > DECAD ( Wolff )


by Loïc Grattier - published on , updated on


  • Cerpa J-C, Coutureau E., Parkes S. (2021) Dopamine and noradrenaline modulation of goal-directed behaviour in prefrontal areas: Toward a division of labour? Special Issue "The magical Orbitofrontal Cortex", Murray E., Gottfried J., Khamassi M., Pessiglione M., Schoenbaum G. (Eds), Behavioral Neuroscience, 135(2):138-153
  • Naneix F., Bakoyiannis I., Santoyo-Zedillo M.; Bosh-Bouju C., Pacheco-Lopez G, Coutureau E.*; Ferreira G.* (2021) Chemogenetic silencing of hippocampus and amygdala reveals a double dissociation in periadolescent obesogenic diet-induced memory alterations, Neurobiology of Learning and Memory, 78:107354, * contributed equally as senior authors


  • Cerpa J-C, Marchand A.R., Salafranque Y., Pape J-R., Kremer E.J., Coutureau E. (2020) Targeting catecholaminergic systems in transgenic rats with a CAV-2 vector harbouring a Cre-dependent DREADD cassette, Frontiers in Molecular Neuroscience , 13:121, doi: 10.3389/fnmol.
  • Turner KM, Parkes SL (2020) Prefrontal regulation of behavioural control: Evidence from learning theory and translational approaches in rodents. Neuroscience & Biobehavioral Reviews 118:27–41.
  • Quet E, Majchrzak M, Cosquer B, Morvan T, Wolff M, Cassel J-C, Pereira de Vasconcelos A, Stéphan A (2020) The reuniens and rhomboid nuclei are necessary for contextual fear memory persistence in rats. Brain Struct Funct Available at: [Accessed March 12, 2020].


  • Morceau S, Piquet R, Wolff M, Parkes SL (2019) Targeting reciprocally connected brain regions through CAV-2 mediated interventions. Frontiers in Molecular Neuroscience, doi: 10.3389/fnmol.2019.00303.
  • Bonhomme D, Alfos S, Webster SP, Wolff M, Pallet V, Touyarot K (2019) Vitamin A deficiency impairs contextual fear memory in rats: Abnormalities in the glucocorticoid pathway. J Neuroendocrinol. 15:e12802. doi: 10.1111/jne.12802
  • Wolff M. and Vann S.D. (2019) The Cognitive Thalamus as a Gateway to Mental Representations, Journal of Neuroscience, 39 (1) 3-14
  • Cinotti F., Fresno V., Aklil N., Coutureau E., Girard B. Marchand A.R.*, Khamassi M.* (2019) Dopamine activity controls exploratory choices, Scientific Reports, 9:6770 * contributed equally as senior authors
  • Cerpa J-C, Marchand A.R.*, Coutureau E.* (2019) Distinct regional patterns in noradrenergic innervation of the rat prefrontal cortex, Journal of Chemical Neuroanatomy, 96: 102-109, * contributed equally as senior authors
  • Cinotti, F., Marchand, A., Roesch, M.R., Girard, B., Khamassi, M. (2019) Impacts of inter-trial interval duration on a computational model of sign-tracking vs. goal-tracking behaviour, Psychopharmacology. Vol 236 No 8 Pages 2373-2388.


  • Lee B., Gentry R., Bissonette G., J. Rae, Mallon J.J., Bryden D.W., Calu D., Schoenbaum G., Coutureau E., Marchand A.R., Khamassi M., Roesch M. (2018) Manipulating the revision of reward value associated to conditioned and unconditioned stimuli increases sign tracking and dopamine release, Plos Biology, 16(9):e2004015
  • Coutureau E., Parkes S. Cortical determinants of goal-directed behavior (2018) In: Goal-Directed Decision Making: Computations and Neural Circuits, Eds: Richard Morris, Aaron Bornstein & Amitai Shenhav, Elsevier, 2018
  • Parkes S., Ravassard P., Cerpa J-C., Wolff M., Ferreira G., Coutureau E. (2018) Insular and ventrolateral orbitofrontal cortices differentially contribute to goal-directed behavior in rodents, Cerebral Cortex. 28, 2313–2325
  • Labrousse V.F., Leyrolle Q., Amadieu C., Aubert A., Sere A, Coutureau E., Grégoire S., Bretillon L., Pallet V., Gressens P., Joffre C., Nadjar A., Layé S. (2018) Dietary omega-3 deficiency exacerbates inflammation and reveals spatial memory deficits in mice exposed to lipopolysaccharide during gestation, Brain Behavior and Immunity, 73: 427-440.
  • Fitoussi A., Renault P., Le Moine C., Coutureau E., Cador M., Dellu-Hagedorn F. (2018) Inter-individual differences in decision-making, flexible and goal-directed behaviors: novel insights within the prefronto-striatal networks. Brain Structure and Function, 223: 897-912
  • Naneix F., Darlot, F., De Smedt-Peyrusse V., Pape J-R., Coutureau E.*, Cador M.* (2018) Protracted motivational dopamine-related deficits following adolescence sugar overconsumption, Neuropharmacology, 129:16-25, * contributed equally as senior authors


  • Naneix F., Tantot F., Glangetas C., Kaufling J., Janthakhin Y., Boitard C., De Smedt-Peyrusse V., Pape J-R., Vancassel S., Trifilieff P., Georges F., Coutureau E., Ferreira G. (2017) Impact of early consumption of high-fat diet on the mesolimbic dopaminergic system, eNeuro, 4(3) e0120-17.2017 1–12
  • Lansade L., Marchand A.R., Coutureau E., Ballé C., Polli F., Calandreau L. (2017) Personality and predisposition to form habit behaviour: evidence from a contingency degradation task in horse, PlosOne, 2(2):e0171010
  • Tantot, F., Parkes S., Marchand A.R., Boitard C., Naneix F., Layé S., Trifilieff P., Coutureau E.*, Ferreira G.* (2017) Obesogenic diet intake changes the coordination of food-related actions and habits, Appetite, 108:203-211, * contributed equally as senior authors


  • Boitard C.*, Parkes S.*, Cavaroc A., Tantot F., Sauvant J., Layé S., Castanon N., Tronel S., Gustavo Pacheco-Lopez, Coutureau E., Ferreira G. Switching adolescent high-fat diet to adult control diet restores neurocognitive alterations, Frontiers in Behavioral Neuroscience, In press, *contributed equally
  • Alcaraz F, Marchand AR, Courtand G, Coutureau E, Wolff M. Parallel inputs from the mediodorsal thalamus to the prefrontal cortex in the Rat. European Journal of Neuroscience, 44:1972-86
  • Parkes S.L., Marchand A.R., Ferreira G.*, Coutureau E.* A time course analysis of satiety-induced instrumental outcome devaluation. Learning and Behavior, 44: 347-355. *contributed equally as senior authors
  • Naneix F., Darlot F, Coutureau E and Cador M (2016) Long lasting deficits in hedonic and nucleus accumbens reactivity to sweet rewards by sugar overconsumption during adolescence. European Journal of Neuroscience, 43:671-680.
  • Parkes S., Ferreira G.*, Coutureau E.* (2016) Acquisition of specific response-outcome associations requires NMDA receptor activation in the basolateral amygdala but not in the insular cortex, Neurobiology of Learning and Memory, 128: 40-45. * contributed equally as senior authors
  • Alcaraz F.*, Naneix F.*, Desfosse E., Marchand A.R., Wolff M.#, Coutureau E.#, (2016) Dissociable effects of anterior and mediodorsal thalamic lesions on spatial goal-directed behavior. Brain, Structure & Function 221(1):79-89. * contributed equally. # Contributed equally as senior authors.


  • Alcaraz, F., Marchand, A.R., Vidal , E., Guillou, A., Faugere, A., Coutureau, E., Wolff M (2015) Flexible use of predictive cues beyond the orbitofrontal cortex: role of the submedius thalamic nucleus. Journal of Neuroscience, 35: 13183-193.
  • Wolff M, Alcaraz, F., Marchand, A.R. & Coutureau, E. Functional heterogeneity of the limbic thalamus: From hippocampal to cortical functions. Neuroscience and Bio Behavioral Reviews , 54: 120-130.
  • Wolff M, Faugere, A., Desfosses, E., Coutureau, E. & Marchand, A.R. Mediodorsal but not anterior thalamic nuclei lesions impair acquisition of a conditional discrimination task. Neurobiology of Learning and Memory, 125, 80-84.
  • Boitard C., Maroun M., Tantot F., Cavaroc A., Sauvant J., Marchand A.R., Layé S., Capuron L., Darnaudery M., Castanon N., Coutureau E., Vouimba R.-M., Ferreira G. Juvenile obesity enhances emotional memory and amygdala plasticity through glucocorticoids. Journal of Neuroscience, 35(9):4092-103
  • Dalrymple-Alford J., Harland B., Loukavenko E., Perry B., Mercer S., Collings D., Ulrich K., Abraham W., McNaughton N., Wolff M. Anterior thalamic nuclei lesions and recovery of function: Relevance to cognitive thalamus. Neuroscience and Bio Behavioral Reviews, 54:145-160
  • Delpech J.C., Saucisse N., Parkes S., Lacabanne N, Aubert A, Casenave F, Coutureau E., Sans N., Layé S., Ferreira G., Nadjar A. Microglial activation enhances associative taste memory through purinergic modulation of glutamatergic neurotransmission. Journal of Neuroscience, 35(7):3022-33


  • Loukavenko EA, Wolff M, Poirier GL, Dalrymple-Alford JC. Impaired spatial working memory after anterior thalamic lesions: recovery with cerebrolysin and enrichment. Brain Structure and Function, In Press.
  • Marchand A, Faugère A, Coutureau E, Wolff M. A role for anterior thalamic nuclei in contextual fear conditioning. Brain Structure and Function, 219:1575-86
  • Parkes S., De la Cruz V., Bermudez-Rattoni F., Coutureau E., Ferreira G. Differential role of insular cortex muscarinic and NMDA receptors in one-trial appetitive taste learning. Neurobiology of Learning and Memory, 116:112-6


  • Dupire A, Kant P, Mons N, Marchand AR, Coutureau E, Dalrymple-Alford J, Wolff M (2013) A role for anterior thalamic nuclei in affective cognition: interaction with environmental conditions. Hippocampus, 3:392-404.
  • Lansade L, Coutureau E; Marchand AR; Valenchon M; Baranger G; Calandreau L. Dimensions of Temperament Modulate Cue-Controlled Behavior: A Study on Pavlovian to Instrumental Transfer in Horses (Equus Caballus). Plos One, 8(6):e64853.
  • Mendez-Lopez M; Arias JL ; Bontempi B; Wolff M. (2013) Reduced cytochrome oxidase activity in the retrosplenial cortex after lesions to the anterior thalamic nuclei. Behavioural Brain Research, 250:250-273.
  • Naneix F, Marchand AR, Pichon A, Pape J-R, Coutureau E. Adolescent stimulation of D2 receptors alters the maturation of dopamine-dependent goal-directed behavior, Neuropsychopharmacology, 38(8):1566-74.
  • Rivalan M, Valton V, Seriès P, Marchand AR, Dellu Hagedorn F (2013) Elucidating poor decision-making in a rat gambling task. PLoS One, 8(12):e82052.


  • Coutureau E, Esclassan F, Di Scala G, Marchand AR (2012) The role of the Rat medial prefrontal cortex in adapting to changes in instrumental contingency. PLoS ONE 7(4):e33302.
  • Moreau P-H, Tsenkina Y, Lecourtier L, Lopez J, Cosquer B, Wolff M, Dalrymple-Alford J, Cassel J-C. (2012) Lesions of the anterior thalamic nuclei and intralaminar thalamic nuclei: place and visual discrimination learning in the water maze. Brain Structure and Functions, 2012 Apr 29.
  • Naneix F, Marchand AR, Di Scala G, Pape J-R, Coutureau E (2012) Parallel maturation of goal-directed behavior and dopaminergic systems during adolescence. Journal of Neuroscience, 32:16223-16232.


  • Dutech A, Coutureau E, Marchand AR (2011) A reinforcement learning approach to instrumental contingency degradation in rats. Journal of Physiology – Paris 105:36-44.
  • Porte Y, Trifilieff P, Wolff M, Micheau J, Buhot M-C, Mons N (2011) Extinction of spatial memory alters CREB phosphorylation in hippocampal CA1. Hippocampus, 21: 1169-1179
  • Rivalan M., Coutureau E., Fitoussi A., Dellu-Hagedorn F. (2011) Inter-individual decision-making differences in the effects of cingulate, orbitofrontal and prelimbic cortex lesions in a rat gambling task Journal: Frontiers in Behavioral Neuroscience, 2011 Apr 27;5:22.
  • San-Galli A, Marchand AR, Decorte L, Di Scala G (2011) Retrospective revaluation and its neural circuit in rats. Behav Brain Res 223: 262-270


  • Dutech A, Coutureau E, Marchand AR (2010) Reinforcement learning approaches to instrumental contingency degradation in rats. In: 5ème Conférence Française de Neurosciences Computationnelles. Lyon.
  • Holmes NM, Marchand AR, Coutureau E (2010) Pavlovian to instrumental transfer: a neurobehavioural perspective. Neurosci Biobehav Rev 34:1277-1295.
  • Segu L, Lecomte M-J, Wolff M, Santamaria J, Hen R, Dumuis A, Berrard S, Bockaert J, Buhot M-C, Compan V (2010) Hyperfunction of muscarinic receptor maintains long-term memory in 5-HT 4 receptor knock-out mice. PLoS ONE, 5: e9529


  • Coutureau E, Di Scala G (2009) Entorhinal cortex and cognition. Prog Neuropsychopharmacol Biol Psychiatry 33:753-761.
  • Coutureau E, Marchand AR, Di Scala G (2009) Goal-directed responding is sensitive to lesions to the prelimbic cortex or basolateral nucleus of the amygdala but not to their disconnection. Behav Neurosci 123:443-448.
  • Esclassan F, Coutureau E, Di Scala G, Marchand AR (2009) Differential contribution of dorsal and ventral hippocampus to trace and delay fear conditioning. Hippocampus 19:33-44.
  • Esclassan F, Coutureau E, Di Scala G, Marchand AR (2009) A cholinergic-dependent role for the entorhinal cortex in trace fear conditioning. Journal of Neuroscience, 29:8087-8093.
  • Lopez J, Wolff M, Lecourtier L, Cosquer B, Bontempi B, Dalrymple-Alford J, Cassel J.-C (2009) The intralaminar thalamic nuclei contribute to remote spatial memory. Journal of Neuroscience, 29: 3302-3306
  • Naneix F, Marchand AR, Di Scala G, Pape JR, Coutureau E (2009) A role for medial prefrontal dopaminergic innervation in instrumental conditioning. Journal of Neuroscience, 29:6599-6606.
  • Pape JR, Bertrand SS, Lafon P, Odessa MF, Chaigniau M, et al. (2009) Expression of GABA(A) receptor alpha3-, theta-, and epsilon-subunit mRNAs during rat CNS development and immunolocalization of the epsilon subunit in developing postnatal spinal cord. Neuroscience 160: 85-96
  • Tran-Tu-Yen DA, Marchand AR, Pape JR, Di Scala G, Coutureau E (2009) Transient role of the rat prelimbic cortex in goal-directed behaviour. Eur J Neurosci 30:464-471.