Institut de Neurosciences Cognitives et Intégratives d'Aquitaine (UMR5287)

Aquitaine Institute for Cognitive and Integrative Neuroscience

Université de Bordeaux

Zone nord Bat 2 2ème étage
146, rue Léo Saignat
33076 Bordeaux cedex


Supervisory authorities

CNRS Ecole Pratique des Hautes Etudes Université de Bordeaux

Our partners

Neurocampus Unitéde Formation de Biologie


GDR Robotique GDR Mémoire GDR Multi-électrodes


Home > Teams > Neurobiology of behavior (Y.CHO)


by Loïc Grattier - published on , updated on


  • Cayzac S, Ginguay A, Mons N, Allinquant B, Jeantet Y, Cho YH (2015) Altered hippocampal information coding and network synchrony in APP-PS1 mice, Neurobiology of Aging, Sep 1. pii: S0197-4580(15)00440-6..
  • Ragot A, Pietropaolo S, Vincent J, Delage P, Zhang H, Allainquant B, Leinkugel X, Fischer A, Cho YH (2015) Inhibition of the Histone Deacetylase 6 exacerbates selected behavioral deficits in the R6/1 mouse model for huntington’s disease, Brain and Behavior, 2015; 0(0), e00361.
  • Delprato A, Bonheur B, Algéo MP, Rosay P, Lu L, Williams RW, Crusio WE (2015) Systems genetic analysis of hippocampal neuroanatomy and spatial learning in mice. Genes Brain Behav. Oct 9. doi: 10.1111/gbb.12259.
  • Oddi D, Subashi E, Middei S, Bellocchio L, LeMaire-Mayo V, Guzman M, Crusio WE, D’amato FR, Pietropaolo S (2015) Early social enrichment rescues adult behavioral and brain abnormalities in a mouse model of fragile X syndrome. Neuropsychopharmacology, 40:1113-22.
  • Lebreton F, Cayzac S, Pietropaolo S, Jeantet Y, Cho YH (2015) Sleep physiology alterations precede plethoric phenotypic changes in R6/1 Huntington’s disease mice, PlosOne, 10:e0126972.
  • Dallerac GM, Levasseur G, Vatsavayai SC, Milnerzood AJ, Cummings DM, Kraev I, Huetz C, Evans KA, Walters SW, Rezaie P, Cho YH, Hirst MC, Murphy KPSJ (2015) Dysfunctional dopaminergic neurons in mouse models of Huntington’s disease. Neurodegenerative diseases, 15:93-108.
  • Roubaud Baudrona C, Chambonnier L, Giese A, Macrez N, Cho YH, Fénelon V, Blaszczyk L, Dubus P, Mégraud F, Salles N and Varon C. (2015) Eighteen months Helicobacter infection does not induce amyloid plaque in brains of wild type C57BL/6j mice. Journal of Alzheimer’s Disease, in press.
  • Malki K, Mineur YS, Tosto MG, Campbell J, Karia P, Jumabhoy I, Sluyter F, Crusio WE, Schalkwyk LC (2015) Pervasive and opposing effects of Unpredictable Chronic Mild Stress (UCMS) on hippocampal gene expression in BALB/cJ and C57BL/6J mouse strains. BMC Genomics. 16:262.
  • Milan L, Courtand G, Cardoit L, Masmejean F, Barrière G, Cazalets JR, Garret M, Bertrand SS (2015) Age-Related Changes in Pre- and Postsynaptic Partners of the Cholinergic C-Boutons in Wild-Type and SOD1G93A Lumbar Motoneurons. PLoS One. 10:e0135525.
  • Cho YH & Jeantet Y (2016) Altered neural networks underlying cognitive deficits in a transgenic mouse model of Huntington’s disease. In: The Neurobiological Basis of Memory: A System, Attribute, and Process Analysis (A Festschrift in Honor of Raymond P. Kesner), p. Eds. M. Ragozzino, et al., Springer.
  • Froux L, Suarez-Boomgaard D, Baufreton J, Rivera A, Garret M & Taupignon A (2015) Dopamine receptors in the subthalamic nucleus: Identification and localisation of D5 receptors. In: Neuromethods, Ed. M. Tiberi,© Humana Press.


  • Pietropaolo S, Feldon J & Yee BK (2014) Environmental enrichment eliminates the anxiety phenotypes in a triple transgenic mouse model of Alzheimer’s disease. Cognitive and Affective Behavioral Neuroscience 4, 996-1008.
  • Tronel S, Lemaire V, Charrier V, Montaron MF & Abrous DN (2014) Influence of ontogenetic age on the role of dentate granule neurons. Brain Structure and Function 220:645-61.
  • Pietropaolo S, Goubran M, Joffre C, Aubert A, Lemaire-Mayo V, Crusio WE & Layé S (2014) Dietary supplementation of omega-3 fatty acids rescues selected Fragile X-like phenotypes in Fmr1-KO mice. Psychoneuroendocrinology 49: 119-129.
  • Hebert B, Pietropaolo S, Meme S, Laudier B, Laugeray A, Doisne N, Quartier A, Lefeuvre S, Got L, Cahard D, Laumonnier F, Crusio WE, Pichon J, Menuet A, Perche O & Briault S (2014) Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by a BKCa channel opener molecule. Orphanet Journal of Rare Diseases 9, 124.
  • Cho YH & Pietropaolo S (2014) Huntington’s disease. In: Behavioral Genetics of the Mouse: Genetics Mouse Models of Neurobehavioral Disorders, p. 436-446 Eds. S. Pietropaolo, F. Sluyter, and W.E. Crusio, Cambridge University Press: Cambridge.
  • Chaumont S & Garret M (2014) The γ2(R43Q) mutation linked to epilepsy affects GABAA receptor internalization. Molecular & Cellular Epilepsy 1, 1: 4-6.
  • Garret M, Boué-Grabot E &Taly A. (2014) Long distance effect on ligand-gated ion channels extracellular domain may affect interactions with the intracellular machinery. Communicative & Integrative Biology 7, e27984.
  • Pietropaolo S, Bellocchio L, Ruiz-Calvo A, Cabanas M, Du Z, Guzman M, Garret M & Cho Y (2014) Chronic cannabinoid receptor stimulation selectively prevents motor impairments in a mouse model of Huntington’s disease. Neuropharmacology, 89:368-74.
  • Zhang Y, Bonnan A, Bony G, Ferezou I, Pietropaolo S, Ginger M, Sans N, Rossier J, Oostra B, LeMasson G, Frick A (2014) Dendritic channelopathies contribute to neocortical and sensory hyperexcitability in Fmr1(-/y) mice. Nature Neuroscience 17:1701-9.
  • Sluyter F, Pietropaolo S & Crusio WE (2014) Genetic mouse models of neuropsychiatric disorders. In: Behavioral Genetics of the Mouse: Genetic Mouse Models of Neurobehavioral Disorders, p. 1-3 Eds. W.E. Crusio, Cambridge University Press: Cambridge, UK.
  • Crusio WE (2014) Key issues in contemporary behavioral genetics. Current Opinion in Behavioral Sciences, 2:89-95, 2015.
  • Pietropaolo S, Sluyter F & Crusio WE, eds. Behavioral Genetics of the Mouse: Genetic Mouse Models of Neurobehavioral Disorders. Cambridge Handbooks in Behavioral Genetics, ed. W.E. Crusio. Vol. 2. 2014, Cambridge University Press: Cambridge, UK.


  • Chaumont S, Andre C, Perrais D, Boue-Grabot E, Taly A & Garret M (2013) Agonist-dependent endocytosis of gamma-aminobutyric acid type A (GABAA) receptors revealed by a gamma2(R43Q) epilepsy mutation. Journal of Biological Chemistry 288, 28254-65.
  • Jeantet Y, Cayzac S & Cho YH (2013) beta oscillation during slow wave sleep and rapid eye movement sleep in the electroencephalogram of a transgenic mouse model of Huntington’s disease. PLoS ONE 8, e79509.
  • Oddi D, Crusio WE, D’Amato FR & Pietropaolo S (2013) Monogenic mouse models of social dysfunction: Implications for autism. Behavioural Brain Research 251, 75-84.
  • Schughart K, Libert C, Andreux P, Aransay AM, Auwerx J, Balling R, Banerjee S, Bezerianos A, Bragonzi AD, Brockmann GA, Brown S, Campbell-Tofte J, Cendelin J, Chatziioannou A, Chen D, Crusio WE, Dimitrakopoulou K, Falcon JM, Forejt J, Franken P, Fröhlich LF, Herault Y, Hovatta I, Iraqi FA, Jansen RC, Kaczmarek L, Knapska E, Koks S, Kolisis F, Korostynski M, Lammert F, Lehrach H, Lengeling A, Montagutelli X, Mott R, Panthier J-J, Przewlocki R, Ranki A, Santos J, Severcan F, Schalkwyk L, Smit AB, Terasmaa A, Vasar E, Zatloukal K & Kas MJ (2013) Controlling complexity: the clinical relevance of mouse complex genetics. European Journal of Human Genetics 21, 1191-1196.
  • Crusio WE (2013) The genetics of exploratory behavior. In: Behavioral Genetics of the Mouse: Genetics of Behavioral Phenotypes, p. 148-154 Eds. W.E. Crusio, et al., Cambridge University Press: Cambridge, United Kingdom.
  • Crusio WE (2013) Radial maze. In: Behavioral Genetics of the Mouse: Genetics of Behavioral Phenotypes, p. 299-303 Eds. W.E. Crusio, et al., Cambridge University Press: Cambridge, United Kingdom.
  • Crusio WE & Gerlai RT (2013) Behavior genetics. Where do we come from and where are we going. In: Behavioral Genetics of the Mouse: Genetics of Behavioral Phenotypes, p. 1-4 Eds. W.E. Crusio, et al., Cambridge University Press: Cambridge, United Kingdom.
  • Crusio WE, Sluyter F & Gerlai RT (2013) Ethogram of the mouse. In: Behavioral Genetics of the Mouse: Genetics of Behavioral Phenotypes, p. 17-22 Eds. W.E. Crusio, et al., Cambridge University Press: Cambridge, United Kingdom.
  • Crusio WE, Sluyter F, Gerlai RT & Pietropaolo S, eds. Behavioral Genetics of the Mouse: Genetics of Behavioral Phenotypes. Cambridge Handbooks in Behavioral Genetics, ed. W.E. Crusio. Vol. 1. 2013, Cambridge University Press: Cambrudge, UK. xiii+345.


  • Crusio WE (2012) Heritability estimates in behavior genetics: wasn’t that station passed long ago? Behav Brain Sci 35, 361-2.
  • Crusio WE (2012) Books in short. Genes, Brain and Behavior 11, 374.
  • Jeantet Y & Cho YH (2012) Evolution of hippocampal spatial representation over time in mice. Neurobiology of Learning and Memory 98, 354-60.
  • Lagadec S, Rotureau L, Hemar A, Macrez N, Delcasso S, Jeantet Y & Cho YH (2012) Early temporal short-term memory deficits in double transgenic APP/PS1 mice. Neurobiology of Aging 33, 203 e1-11.
  • Lemaire V, Tronel S, Montaron MF, Fabre A, Dugast E & Abrous DN (2012) Long-lasting plasticity of hippocampal adult-born neurons. Journal of Neuroscience 32, 3101-8.
  • Pietropaolo S, Delage P, Lebreton F, Crusio WE & Cho YH (2012) Early development of social deficits in APP and APP-PS1 mice. Neurobiology of Aging 33, 1002 e17-27.
  • Pietropaolo S & Crusio WE (2012) Learning spatial orientation. In: Encyclopedia of the Sciences of Learning, p. 1969-1971 Eds. N.M. Seel, Springer.


  • Cayzac S, Delcasso S, Paz V, Jeantet Y & Cho YH (2011) Changes in striatal procedural memory coding correlate with learning deficits in a mouse model of Huntington disease. Proceedings of the National Academy of Sciences of the USA 108, 9280-5.
  • Jo YH, Donier E, Martinez A, Garret M, Toulme E & Boue-Grabot E (2011) Cross-talk between P2X4 and gamma-aminobutyric acid, type A receptors determines synaptic efficacy at a central synapse. Journal of Biological Chemistry 286, 19993-20004.
  • Pietropaolo S & Crusio WE (2011) Genes and cognition. Wiley Interdisciplinary Reviews: Cognitive Science 2, 345-352.
  • Pietropaolo S, Delage P, Cayzac S, Crusio WE & Cho YH (2011) Sex-dependent changes in social behaviors in motor pre-symptomatic R6/1 mice. PLoS ONE 6, e19965.
  • Pietropaolo S, Guilleminot A, Martin B, D’Amato FR & Crusio WE (2011) Genetic-background modulation of core and variable autistic-like symptoms in Fmr1 knock-out mice. PLoS ONE 6, e17073.


  • Cho YH & Jeantet Y (2010) Differential involvement of prefrontal cortex, striatum, and hippocampus in DRL performance in mice. Neurobiology of Learning and Memory 93, 85-91.
  • Schughart K, Arends D, Andreux P, Balling R, Beyer A, Bezerianos A, Brockmann G, Crusio WE, Campbell-Tofte J, Denny P, Falcon-Perez JM, Forejt J, Franken P, Hovatta I, Iraqi F, Jansen RC, Kaczmarek L, Kas MJ, Kashofer K, Knapska E, Kolisis F, Kõks S, Möller S, Montagutelli X, Morahan G, Mott R, Pfoertner S, Prins P, Przewlocki R, Ranki A, Santos J, Rihet P, Schalkwyk L, Smit AB, Swertz M, Threadgill D, Vasar E & Zatloukal K (2010) SYSGENET: a meeting report from a new European network for systems genetics. Mammalian Genome 21, 331-336.
  • Pietropaolo S (2010) Le personalità animali. In: Enciclopedia Treccani, “XXI Secolo: Il corpo e la mente”, p. 707-717 Eds.
  • Pietropaolo S (2010) Aggressività. In: Dizionario di Medicina, Enciclopedia Treccani, p. 707-717 Eds.


  • Belujon P, Baufreton J, Grandoso L, Boue-Grabot E, Batten TF, Ugedo L, Garret M & Taupignon AI (2009) Inhibitory transmission in locus coeruleus neurons expressing GABAA receptor epsilon subunit has a number of unique properties. Journal of Neurophysiology 102, 2312-25.
  • Ciofi P, Garret M, Lapirot O, Lafon P, Loyens A, Prevot V & Levine JE (2009) Brain-endocrine interactions: a microvascular route in the mediobasal hypothalamus. Endocrinology 150, 5509-19.
  • Crusio WE, Goldowitz D, Holmes A & Wolfer D (2009) Standards for the publication of mouse mutant studies. Genes, Brain and Behavior 8, 1-4.
  • Knuesel I, Nyffeler M, Mormede C, Muhia M, Meyer U, Pietropaolo S, Yee BK, Pryce CR, LaFerla FM, Marighetto A & Feldon J (2009) Age-related accumulation of Reelin in amyloid-like deposits. Neurobiology of Aging 30, 697-716.
  • Koehl M, Lemaire V, Le Moal M & Abrous DN (2009) Age-dependent effect of prenatal stress on hippocampal cell proliferation in female rats. European Journal of Neuroscience 29, 635-40.
  • Mineur YS & Crusio WE (2009) Behavioral effects of ventilated micro-environment housing in three inbred mouse strains. Physiology and Behavior 97, 334-340.
  • Pape JR, Bertrand SS, Lafon P, Odessa MF, Chaigniau M, Stiles JK & Garret M (2009) Expression of GABA(A) receptor alpha3-, theta-, and epsilon-subunit mRNAs during rat CNS development and immunolocalization of the epsilon subunit in developing postnatal spinal cord. Neuroscience 160, 85-96.
  • Pietropaolo S & Crusio WE (2009) Strain-dependent changes in acoustic startle response and its plasticity across adolescence in mice. Behavior Genetics 39, 623-631.
  • Pietropaolo S, Sun Y, Li R, Brana C, Feldon J & Yee BK (2009) Limited impact of social isolation on Alzheimer-like symptoms in a triple transgenic mouse model. Behavioral Neuroscience 123, 181-195.
  • Sachidhanandam S, Blanchet C, Jeantet Y, Cho YH & Mulle C (2009) Kainate receptors act as conditional amplifiers of spike transmission at hippocampal mossy fiber synapses. Journal of Neuroscience 29, 5000-8.