Institut de Neurosciences Cognitives et Intégratives d'Aquitaine (UMR5287)

Aquitaine Institute for Cognitive and Integrative Neuroscience



INCIA - UMR 5287- CNRS
Université de Bordeaux

Zone nord Bat 2 2ème étage
146, rue Léo Saignat
33076 Bordeaux cedex
France

Téléphone 05.57.57.15.51
Télécopie 05.56.90.14.21

Supervisory authorities

CNRS Ecole Pratique des Hautes Etudes Université de Bordeaux

Our partners

Neurocampus Unitéde Formation de Biologie

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GDR Robotique GDR Mémoire GDR Multi-électrodes

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Home > Teams > EMOTIV ( Caillé-Garnier / David )

Presentation

by Loïc Grattier - published on , updated on

Emotion, Motivation, Cognition (EMOTIV)

Rewarding and aversive states as induced by natural stimuli or drugs of abuse are related to brain circuits (reward and stress systems) which guide adaptive responses to the environment, according to individual cognitive and learning strategies. While organizing behavior and promoting resilience in some subjects, emotional states can evolve into pathological states such as anxiety, depression or addiction. EMOTIV project relies on “mirrored” approaches aiming at understanding neural dynamics of valence (rewarding or aversive) and value of events/stimuli, the "shift” which occurs with chronicity, internal (bodily) vs external context changes, and cognitive (or loss of) control (Theme 1: Emotional Control of Cognition). We also investigate the influence of individual cognitive traits on behavioral and neural responses to emotional stimuli (Theme 2: Cognitive control of Emotions).

Key words: Addiction, Affective Disorders, Alcohol, Cholinergic System, Chronic Stress, Nicotinic Receptors, Positive and Negative Emotions, Reward System

Behavioral paradigms: assessing motivational and affective properties of pharmacological (drugs of abuse) and natural (food) rewards through operant self-administration, conditioned place preference and aversion, goal-directed vs automated behaviors, attention, anxiety, memory, impulsivity, decision-making, sensation or risk-seeking.

System Neuroscience : opto/chemogenetic approaches, temporary inactivation, intracerebral and peripheral pharmacological administrations

Functional neuroanatomy : immediate early gene expression for activity and plasticity markers, in situ hybridization, catFISH, immunohistochemistry, image analysis

Electrophysiology : In vivo recordings in anesthetized and freely moving mice, EFP

Transgenic mouse models, DA system :DR1-Cre, DR2-Cre, DAT-Cre mice
Transgenic mouse models, ACh system :ChAT-Cre, a5KO, a5SNP mice

Team Members

How to reach us (click)
Half of the team is at the Bâtiment B2 (Biologie et Physiologie Animale),
in front of tram stop "Doyen Brus", Allée Geoffroy St Hilaire, Pessac

or here
The other half of the team is located at the Charles Perrens Psychiatric Hospital right next to the University of Bordeaux, 300 meters away from the main building of the INCIA Institute at the Carreire campus