Rewarding and aversive states as induced by natural stimuli or drugs of abuse are related to brain circuits (reward and stress systems) which guide adaptive responses to the environment, according to individual cognitive and learning strategies. While organizing behavior and promoting resilience in some subjects, emotional states can evolve into pathological states such as anxiety, depression or addiction. EMOTIV project relies on “mirrored” approaches aiming at understanding neural dynamics of valence (rewarding or aversive) and value of events/stimuli, the "shift” which occurs with chronicity, internal (bodily) vs external context changes, and cognitive (or loss of) control (Theme 1: Emotional Control of Cognition). We also investigate the influence of individual cognitive traits on behavioral and neural responses to emotional stimuli (Theme 2: Cognitive control of Emotions).
Key words: Addiction, Affective Disorders, Alcohol, Cholinergic System, Chronic Stress, Nicotine, Nicotinic Receptors, Positive and Negative Emotions, Reward System
Behavioral paradigms: assessing motivational and affective properties of pharmacological (drugs of abuse) and natural (food) rewards through operant self-administration, conditioned place preference and aversion, goal-directed vs automated behaviors, attention, anxiety, memory, impulsivity, decision-making, sensation or risk-seeking.
System Neuroscience : opto/chemogenetic approaches, temporary inactivation, intracerebral and peripheral pharmacological administrations
Functional neuroanatomy : immediate early gene expression for activity and plasticity markers, in situ hybridization, catFISH, immunohistochemistry, image analysis
Electrophysiology : In vivo recordings in anesthetized and freely moving mice, EFP
Transgenic mouse models, DA system :DR1-Cre, DR2-Cre, DAT-Cre mice
Transgenic mouse models, ACh system :ChAT-Cre, a5KO, a5SNP mice
Team Members
- Stéphanie Caillé-Garnier, CR1 CNRS, HDR (Team Leader)
- Vincent David, CR1 CNRS, HDR (Team Leader)
- Martine Cador, DR1 CNRS, HDR
- Marc Corio, MCU
- Jean-Louis Guillou, PR1, HDR
- Rose-Marie Vouimba-Siguelnitzky, MCU, ADT
- Florence Darlot, AI CNRS
- Nadia Henkous, Tech CNRS
- Maria Carmen Medrano, Postdoc
- Léa Tochon, Postdoc
- Cécile Pagèze, PhD student
- Alice Minard, PhD student
How to reach us (click)
Half of the team is at the Bâtiment B2 (Biologie et Physiologie Animale),
in front of tram stop "Doyen Brus", Allée Geoffroy St Hilaire, Pessac
or here
The other half of the team is located at the Charles Perrens Psychiatric Hospital right next to the University of Bordeaux, 300 meters away from the main building of the INCIA Institute at the Carreire campus
