Institut de Neurosciences Cognitives et Intégratives d'Aquitaine (UMR5287)

Aquitaine Institute for Cognitive and Integrative Neuroscience



INCIA - UMR 5287- CNRS
Université de Bordeaux

Zone nord Bat 2 2ème étage
146, rue Léo Saignat
33076 Bordeaux cedex
France

Téléphone 05.57.57.15.51
Télécopie 05.56.90.14.21

Supervisory authorities

CNRS Ecole Pratique des Hautes Etudes Université de Bordeaux

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Neurocampus Unitéde Formation de Biologie

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Lasserre Jean-Paul

by NRGEN - published on , updated on

MCU Bordeaux Univ, HDR

Contact:
jean-paul.lasserre@u-bordeaux.fr

Team:
Translational Research in Neurogenetic Diseases

Domain:
Biochemistry
Metabolism / Bioenergetics

Research axis:

  • Physiopathological studies of Neurodegeneration with brain iron accumulation (NBIA)

Scientific expertise:

  • Yeast Model
  • Drug Screening
  • Metabolism / Bioenergetics

Selected publications:

  • de Taffin de Tilques M, Lasserre JP, Godard F, Sardin E, Bouhier M, Le Guedard M, Kucharczyk R, Petit PX, Testet E, di Rago JP, Tribouillard-Tanvier D. (2018) Decreasing cytosolic translation is beneficial to yeast and human Tafazzin-deficient cells. Microb Cell. 5(5):220-232. doi: 10.15698/mic2018.05.629.
  • Skoczeń N, Dautant A, Binko K, Godard F, Bouhier M, Su X, Lasserre JP, Giraud MF, Tribouillard-Tanvier D, Chen H, di Rago JP, Kucharczyk R. (2018) Molecular basis of diseases caused by the mtDNA mutation m.8969G>A in the subunit a of ATP synthase. Biochim Biophys Acta Bioenerg. 1859(8):602-611. doi: 10.1016/j.bbabio.2018.05.009.
  • de Taffin de Tilques M, Tribouillard-Tanvier D, Tétaud E, Testet E, di Rago JP, Lasserre JP. (2017) Overexpression of mitochondrial oxodicarboxylate carrier (ODC1) preserves oxidative phosphorylation in a yeast model of Barth syndrome. Dis Model Mech. 10(4):439-450. doi: 10.1242/dmm.027540.
  • Sellem CH, di Rago JP, Lasserre JP, Ackerman SH, Sainsard-Chanet A. (2016) Regulation of Aerobic Energy Metabolism in Podospora anserina by Two Paralogous Genes Encoding Structurally Different c-Subunits of ATP Synthase. PLoS Genet. 12(7):e1006161. doi: 10.1371/journal.pgen.1006161.
  • Niedzwiecka K, Kabala AM, Lasserre JP, Tribouillard-Tanvier D, Golik P, Dautant A, di Rago JP, Kucharczyk R. (2016) Yeast models of mutations in the mitochondrial ATP6 gene found in human cancer cells. Mitochondrion. 29:7-17. doi: 10.1016/j.mito.2016.04.003.
  • Beaumatin F, El Dhaybi M, Lasserre JP, Salin B, Moyer MP, Verdier M, Manon S, Priault M. (2016) N52 monodeamidated Bcl‑xL shows impaired oncogenic properties in vivo and in vitro. Oncotarget. 7(13):17129-43. doi: 10.18632/oncotarget.7938.
  • Lasserre JP, Dautant A, Aiyar RS, Kucharczyk R, Glatigny A, Tribouillard-Tanvier D, Rytka J, Blondel M, Skoczen N, Reynier P, Pitayu L, Rötig A, Delahodde A, Steinmetz LM, Dujardin G, Procaccio V, di Rago JP. (2015) Yeast as a system for modeling mitochondrial disease mechanisms and discovering therapies. Dis Model Mech. 8(6):509-26. doi: 10.1242/dmm.020438. Review.
  • Kabala AM, Lasserre JP, Ackerman SH, di Rago JP, Kucharczyk R. (2014) Defining the impact on yeast ATP synthase of two pathogenic human mitochondrial DNA mutations, T9185C and T9191C. Biochimie. 100:200-6. doi: 10.1016/j.biochi.2013.11.024.
  • Ostojić J, Panozzo C, Lasserre JP, Nouet C, Courtin F, Blancard C, di Rago JP, Dujardin G. (2013) The energetic state of mitochondria modulates complex III biogenesis through the ATP-dependent activity of Bcs1. Cell Metab. 1;18(4):567-77. doi: 10.1016/j.cmet.2013.08.017.
  • Lasserre JP, Plissonneau J, Velours C, Bonneu M, Litvak S, Laquel P, Castroviejo M. (2013) Biochemical, cellular and molecular identification of DNA polymerase α in yeast mitochondria. Biochimie. 95(4):759-71. doi: 10.1016/j.biochi.2012.11.003.
  • Lasserre JP, Ménard A. (2012) Two-dimensional blue native/SDS gel electrophoresis of multiprotein complexes. Methods Mol Biol. 869:317-37. doi: 10.1007/978-1-61779-821-4_27.
  • Lasserre JP, Fack F, Serchi T, Revets D, Planchon S, Renaut J, Hoffmann L, Gutleb AC, Muller CP, Bohn T. (2012) Atrazine and PCB 153 and their effects on the proteome of subcellular fractions of human MCF-7 cells. Biochim Biophys Acta. 1824(6):833-41. doi: 10.1016/j.bbapap.2012.03.014.

Patent:

  • Lasserre JP, di Rago JP, Tribouillard D. Compounds for treating Barth Syndrome. Publication number: WO2018/104172 A1. Publication date: 14/06/2018