DR CNRS
Contact:
serge.ahmed@u-bordeaux.fr
+33 (0)5 57 57 15 54
Site : Carreire
Team:
Choice, Addiction and Neurodysfunction
Social:
Twitter / LinkedIn / Google Scholar
Domain:
Addiction / Neuropsychopharmacology / Behavioral Neuroscience / Experimental Psychology
Research axis:
- Experimental study of addiction using an animal model approach
- Environmental, psychological, and neurobiological determinants of the hallmark stages and behavioral features of addiction, including: escalation of drug use which is a hallmark of the transition to addiction; individual drug preferences; loss of control under the influence; craving; and vulnerability to relapse
Scientific expertise:
- Operant and Pavlovian conditioning technologies
- Behavioral economics, choice and decision-making procedures
- PK/PD modeling of drug self-administration
- Conception, development, and validation of addiction models in animals
- Conceptual analysis of addiction theories
Projects:
- Psychological and neurobiological mechanisms involved in choice between drug and nondrug rewards
- Psychological and neurobiological mechanisms involved in loss of control under the drug influence
- Psychological and neurobiological mechanisms involved in drug intake escalation
Funding:
- CNRS / Université de Bordeaux
- ANR PRC (2020-2024), 378k€ (PI), Cocaine users under the influence: processes and mechanisms.
- FRM (2014-2018), 284 k€ (PI), Pathological decision-making in cocaine addiction: causal role of orbitofrontal neuronal activity.
Selected publications:
- Ahmed SH, Badiani A, Miczek K, Müller CP (2020) Non-pharmacological factors that determine drug use and addiction. Neuroscience & Biobehavioral Reviews 110:3-27.
- Vandaele Y, Lenoir M, Vouillac-Mendoza C, Guillem K, Ahmed SH (2021). Probing the decision-making mechanisms underlying choice between drug and nondrug rewards in rats. eLife 26;10:e64993.
- Canchy L, Girardeau P, Durand A, Vouillac-Mendoza C, Ahmed SH (2021) Pharmacokinetics trumps pharmacodynamics during cocaine choice: a reconciliation with the dopamine hypothesis of addiction. Neuropsychopharmacology 46(2):288-296.
- Vandaele Y, Ahmed SH (2021) Habit, choice and addiction. Neuropsychopharmacology 46:689-698.
- Durand A, Girardeau P, Freese L, Ahmed SH (2022) Increased responsiveness to punishment of cocaine self-administration after experience with high punishment. Neurospsychopharmacology 47:444-453.